Improving Calibration of Wearable Blood Pressure Monitoring

改进可穿戴血压监测的校准

• 批准号: 9387958
• 负责人: QUAN ZHANG
• 金额: $ 23.69万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9387958
• 关键词: Affect; Ambulatory Blood Pressure Monitoring; Arterial Lines; Arteries; Big Data; Blood Pressure; Blood Pressure Monitors; Calibration; Cardiovascular Diseases; Cause of Death; Cellular Phone; Centenarian; Clinic; Clinical; Data; Development; Devices; Diagnosis; Diagnostic; Disadvantaged; Disease Management; Early Diagnosis; Elasticity; Electronic Health Record; Elements; Emerging Technologies; Ensure; Evaluation; Event; Eyeglasses; Feasibility Studies; Goals; Gold; Health; Home environment; Hour; Human Resources; Hypertension; Information Technology; Measurement; Measures; Medical; Methods; Modeling; Modernization; Monitor; Morphologic artifacts; Motion; Myocardial Infarction; Patients; Performance; Periodicity; Physiologic pulse; Positioning Attribute; Preventive Medicine; Risk; Running; Stroke; Symptoms; Syncope; System; Technology; Temperature; Temporal Arteries; Testing; Time; Tissues; Urination; Vasomotor; Work; base; blood pressure regulation; cardiovascular disorder prevention; cardiovascular disorder risk; cost; design; disorder risk; improved; innovation; mathematical algorithm; novel; novel strategies; outcome forecast; performance tests; precision medicine; pressure; prevent; prototype; routine practice; sensor; simulation; standard measure; tonometry; validation studies

Project Abstract Blood pressure (BP) control is one of the key strategies to help prevent cardiovascular disease (CVD). Conventional cuff-based, BP measurement in the clinic has not fundamentally changed in over 100 years, requiring significant time and effort per measurement for both clinical personnel and the patient, while also being unable to catch transient BP fluctuations. Current ambulatory blood pressure monitoring (ABPM) technologies are based on the same (cuff-based) principles and hence remain obtrusive, require excessive time per measurement and are unable to catch transient BP fluctuations. Our previous work suggests that the superficial temporal artery (STA) tonometry is an optimal approach for wearable, unobtrusive BP monitoring: it is suitable for long-duration use, can be built into a small form-factor, can provide continuous waveform measurements of BP, and is compatible with the latest electronic health records (EHR) and information technologies. As with other non-invasive, cuffless BP technologies, however, STA tonometry suffers from significant calibration challenges. The goal of this R21 project is to develop a wearable BP monitoring module, and investigate and integrate two novel approaches to improve the calibration of STA tonometry: multi-sensor STA tonometry modeling, and adaptive correction of hold-down pressure drift. To make the STA tonometry approach more clinically viable, our goal will be to extend the required calibration interval to at least 4 hours. We will conduct validation studies against gold-standard continuous BP monitoring systems, and also conduct a feasibility study of wearable long-term (12-hour) monitoring using dual-sensor STA tonometry, applying our combined calibration approaches. Stable STA tonometry BP measurements will provide a revolutionary step forward from the current 100-year-old BP measurement standard, and will facilitate major improvements in health management for people who suffer from symptoms and risks of CVD.

项目摘要 控制血压是帮助预防心血管疾病的关键策略之一。 传统的袖带式血压测量在临床上100多年来没有根本改变， 对于临床人员和患者来说，每次测量都需要大量的时间和精力，同时还 无法捕捉到短暂的BP波动。现代动态血压监测(ABPM) 技术基于相同的(基于袖口的)原则，因此仍然引人注目，需要过多 每一次测量的时间，无法捕捉到瞬时的血压波动。我们之前的工作表明， 颞浅动脉(STA)眼压计是可穿戴的、不显眼的血压监测的最佳方法：IT 适合长时间使用，可内置小尺寸，可提供连续波形 测量血压，并与最新的电子健康记录(EHR)和信息兼容 技术。然而，与其他非侵入性、无袖带的BP技术一样，STA眼压计也存在以下问题 重大的校准挑战。这个R21项目的目标是开发一个可穿戴的BP监测模块， 并研究和集成了两种新的方法来改进STA眼压计的校准：多传感器 静态眼压建模和压低压力漂移的自适应校正。进行眼压测量的方法 我们的目标是将所需的校准间隔延长到至少4小时。 我们将对黄金标准的连续血压监测系统进行验证研究，并进行 使用双传感器眼压计进行可穿戴式长期(12小时)监测的可行性研究 综合校准方法。稳定的STA眼压测量将提供革命性的一步 从目前已有100年历史的BP测量标准向前推进，并将促进重大改进 为有心血管疾病症状和风险的人提供健康管理。