Improving Calibration of Wearable Blood Pressure Monitoring

改进可穿戴血压监测的校准

• 批准号: 9387958
• 负责人: QUAN ZHANG
• 金额: $ 23.69万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9387958
• 关键词: Affect; Ambulatory Blood Pressure Monitoring; Arterial Lines; Arteries; Big Data; Blood Pressure; Blood Pressure Monitors; Calibration; Cardiovascular Diseases; Cause of Death; Cellular Phone; Centenarian; Clinic; Clinical; Data; Development; Devices; Diagnosis; Diagnostic; Disadvantaged; Disease Management; Early Diagnosis; Elasticity; Electronic Health Record; Elements; Emerging Technologies; Ensure; Evaluation; Event; Eyeglasses; Feasibility Studies; Goals; Gold; Health; Home environment; Hour; Human Resources; Hypertension; Information Technology; Measurement; Measures; Medical; Methods; Modeling; Modernization; Monitor; Morphologic artifacts; Motion; Myocardial Infarction; Patients; Performance; Periodicity; Physiologic pulse; Positioning Attribute; Preventive Medicine; Risk; Running; Stroke; Symptoms; Syncope; System; Technology; Temperature; Temporal Arteries; Testing; Time; Tissues; Urination; Vasomotor; Work; base; blood pressure regulation; cardiovascular disorder prevention; cardiovascular disorder risk; cost; design; disorder risk; improved; innovation; mathematical algorithm; novel; novel strategies; outcome forecast; performance tests; precision medicine; pressure; prevent; prototype; routine practice; sensor; simulation; standard measure; tonometry; validation studies

Project Abstract Blood pressure (BP) control is one of the key strategies to help prevent cardiovascular disease (CVD). Conventional cuff-based, BP measurement in the clinic has not fundamentally changed in over 100 years, requiring significant time and effort per measurement for both clinical personnel and the patient, while also being unable to catch transient BP fluctuations. Current ambulatory blood pressure monitoring (ABPM) technologies are based on the same (cuff-based) principles and hence remain obtrusive, require excessive time per measurement and are unable to catch transient BP fluctuations. Our previous work suggests that the superficial temporal artery (STA) tonometry is an optimal approach for wearable, unobtrusive BP monitoring: it is suitable for long-duration use, can be built into a small form-factor, can provide continuous waveform measurements of BP, and is compatible with the latest electronic health records (EHR) and information technologies. As with other non-invasive, cuffless BP technologies, however, STA tonometry suffers from significant calibration challenges. The goal of this R21 project is to develop a wearable BP monitoring module, and investigate and integrate two novel approaches to improve the calibration of STA tonometry: multi-sensor STA tonometry modeling, and adaptive correction of hold-down pressure drift. To make the STA tonometry approach more clinically viable, our goal will be to extend the required calibration interval to at least 4 hours. We will conduct validation studies against gold-standard continuous BP monitoring systems, and also conduct a feasibility study of wearable long-term (12-hour) monitoring using dual-sensor STA tonometry, applying our combined calibration approaches. Stable STA tonometry BP measurements will provide a revolutionary step forward from the current 100-year-old BP measurement standard, and will facilitate major improvements in health management for people who suffer from symptoms and risks of CVD.

项目摘要 血压（BP）控制是帮助预防心血管疾病（CVD）的关键策略之一。 诊所中基于袖口的常规BP测量在100多年来没有从根本上发生变化， 为临床人员和患者需要大量的时间和努力，同时也需要 无法捕获短暂的BP波动。当前的门诊血压监测（ABPM） 技术基于相同的（基于袖口的）原理，因此仍然需要过多 每次测量时间，无法捕获瞬态BP波动。我们以前的工作表明 表面颞动脉（STA）Tonometry是可穿戴，不引人注目的BP监测的最佳方法：它 适合长时间使用，可以内置在小型因子中，可以提供连续的波形 BP的测量值，与最新的电子健康记录（EHR）兼容 技术。与其他无侵入性的无袖式BP技术一样，Sta Tonometry遭受了 重大校准挑战。这个R21项目的目的是开发可穿戴的BP监控模块， 并调查并整合了两种改进sta toNometry校准的新方法：多传感器 STA TONOMETRY建模和保持压力漂移的自适应校正。使Sta Tonometry 接近临床上的更可行性，我们的目标是将所需的校准间隔扩展到至少4小时。 我们将针对金标准连续的BP监测系统进行验证研究，并进行 使用双传感器sta Tonometry法对可穿戴的长期（12小时）监测的可行性研究，应用我们 结合校准方法。稳定的STA Tonometry BP测量将提供革命性的步骤 从目前的100年历史的BP测量标准前进，并将促进重大改进 患有症状和CVD风险的人的健康管理。