Aging and the evolution of the sex-specific chromatin structure in Drosophila
果蝇的衰老和性别特异性染色质结构的进化
基本信息
- 批准号:9564331
- 负责人:
- 金额:$ 68.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-30 至 2019-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAgeAgingArchitectureAutomobile DrivingBiological AssayCardiovascular DiseasesCategoriesCause of DeathCell AgingChromatinChromatin StructureChronicComplementDNADNA Transposable ElementsDataDeteriorationDeveloped CountriesDeveloping CountriesDiabetes MellitusDiseaseDrosophila genusEpigenetic ProcessEquilibriumEuchromatinEvolutionFemaleGene ExpressionGene Expression ProfileGene Expression RegulationGenesGenomeGlobal ChangeHeterochromatinHistonesIndividualKaryotypeLifeLinkLongevityMaintenanceMalignant NeoplasmsMeasuresMethodsMolecular ProfilingPatternPolycombProteinsRepressionRoleSamplingSeriesSex ChromosomesStrokeTechniquesTestingTimeTissuesX ChromosomeY Chromosomeage relatedagedautosomecell agechromatin modificationdosageflyhistone modificationmalemortalitynext generation sequencingoverexpressionpromotersex
项目摘要
Aging and the sex-specific chromatin in Drosophila
The chromatin landscape is key for gene regulation, but little is known about
how it differs between sexes, or over adult life. There is accumulating evidence
that chromatin changes during an individual's lifespan contribute to cellular
aging. In particular, loss of heterochromatin has been observed in aged cells of
several species, including Drosophila. Age-specific mortality rates of male flies
are higher and average lifespans are shorter than those of females. Males also
contain substantially more heterochromatic DNA than females, due to the
presence of a large, repeat-rich Y chromosome, and our preliminary data suggest
that the presence of sex chromosomes with different epigenetic profiles in
Drosophila (that is, a hyper-transcribed dosage compensated X chromosome,
and a silenced heterochromatic Y) result in global changes of chromatin structure
between sexes. We propose to compare sex-specific gene expression and
epigenetic profiles in Drosophila species and strains with different sex
chromosome karyotypes across their lifespan, to study the influence of sex-
specific chromatin differences on cellular aging. We will experimentally modify
protein levels of genes involved in heterochromatin maintenance, to directly test
if heterochromatin formation is a main contributor to sex-specific epigenetic
profiles and longevity. Additionally, we will assay chromatin states in time-
series samples, and characterize tissue-specific chromatin states in aged vs.
young flies, to address the temporal dynamics of changes in chromatin during
aging, and potentially important differences in cellular aging across tissues.
果蝇的衰老与性别特异性染色质
染色质景观是基因调控的关键,但人们对此知之甚少。
它在性别之间或成年后的生活中有何不同。有越来越多的证据
人一生中染色质的变化对细胞
衰老。特别是,在老化的细胞中观察到异染色质的丢失。
包括果蝇在内的几个物种。雄蝇的年龄别死亡率
女性的平均寿命比女性高,平均寿命短。男性也
比女性含有更多的异色DNA,这是因为
存在一个大的富含重复序列的Y染色体,我们的初步数据表明
具有不同表观遗传学特征的性染色体的存在
果蝇(即一种超转录剂量补偿的X染色体,
和沉默的异染色质Y)导致染色质结构的整体变化
性别之间的差异。我们建议比较特定性别的基因表达和
不同性别果蝇种系的表观遗传学特征
染色体核型在他们的寿命,以研究性别的影响-
细胞衰老过程中特定染色质的差异。我们将试验性地修改
参与异染色质维持的基因的蛋白质水平,以直接检测
如果异染色质的形成是性别特异性表观遗传的主要因素
个人资料和寿命。此外,我们将及时分析染色质的状态-
系列样本,并表征老年人与老年人的组织特异性染色质状态。
幼蝇,以解决染色质变化的时间动力学
衰老,以及不同组织间细胞衰老的潜在重要差异。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Doris Bachtrog其他文献
Doris Bachtrog的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Doris Bachtrog', 18)}}的其他基金
The formation of Heterochromatin on evolving Y chromosomes
进化中的 Y 染色体上异染色质的形成
- 批准号:
8991068 - 财政年份:2015
- 资助金额:
$ 68.28万 - 项目类别:
The formation of Heterochromatin on evolving Y chromosomes
进化中的 Y 染色体上异染色质的形成
- 批准号:
10331018 - 财政年份:2015
- 资助金额:
$ 68.28万 - 项目类别:
The formation of Heterochromatin on evolving Y chromosomes
进化中的 Y 染色体上异染色质的形成
- 批准号:
9398132 - 财政年份:2015
- 资助金额:
$ 68.28万 - 项目类别:
"Gene Trafficking on an Evolving X Chromosome in Drosophila"
“果蝇进化 X 染色体上的基因贩运”
- 批准号:
8231546 - 财政年份:2010
- 资助金额:
$ 68.28万 - 项目类别:
Comparative genomics of sex chromosomes in Diptera: gene trafficking, dosage comp
双翅目性染色体的比较基因组学:基因运输、剂量比较
- 批准号:
8898095 - 财政年份:2010
- 资助金额:
$ 68.28万 - 项目类别:
"Gene Trafficking on an Evolving X Chromosome in Drosophila"
“果蝇进化 X 染色体上的基因贩运”
- 批准号:
8436307 - 财政年份:2010
- 资助金额:
$ 68.28万 - 项目类别:
Comparative genomics of sex chromosomes in Diptera: gene trafficking, dosage comp
双翅目性染色体的比较基因组学:基因运输、剂量比较
- 批准号:
8698035 - 财政年份:2010
- 资助金额:
$ 68.28万 - 项目类别:
"Gene Trafficking on an Evolving X Chromosome in Drosophila"
“果蝇进化 X 染色体上的基因贩运”
- 批准号:
7866777 - 财政年份:2010
- 资助金额:
$ 68.28万 - 项目类别:
"Gene Trafficking on an Evolving X Chromosome in Drosophila"
“果蝇进化 X 染色体上的基因贩运”
- 批准号:
8037078 - 财政年份:2010
- 资助金额:
$ 68.28万 - 项目类别:
相似海外基金
Developing a Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening among Rural Screening Age-Eligible Adults
制定年轻人介导的干预措施,以增加农村符合筛查年龄的成年人的结直肠癌筛查
- 批准号:
10653464 - 财政年份:2023
- 资助金额:
$ 68.28万 - 项目类别:
Doctoral Dissertation Research: Estimating adult age-at-death from the pelvis
博士论文研究:从骨盆估算成人死亡年龄
- 批准号:
2316108 - 财政年份:2023
- 资助金额:
$ 68.28万 - 项目类别:
Standard Grant
Determining age dependent factors driving COVID-19 disease severity using experimental human paediatric and adult models of SARS-CoV-2 infection
使用 SARS-CoV-2 感染的实验性人类儿童和成人模型确定导致 COVID-19 疾病严重程度的年龄依赖因素
- 批准号:
BB/V006738/1 - 财政年份:2020
- 资助金额:
$ 68.28万 - 项目类别:
Research Grant
Transplantation of Adult, Tissue-Specific RPE Stem Cells for Non-exudative Age-related macular degeneration (AMD)
成人组织特异性 RPE 干细胞移植治疗非渗出性年龄相关性黄斑变性 (AMD)
- 批准号:
10294664 - 财政年份:2020
- 资助金额:
$ 68.28万 - 项目类别:
Sex differences in the effect of age on episodic memory-related brain function across the adult lifespan
年龄对成人一生中情景记忆相关脑功能影响的性别差异
- 批准号:
422882 - 财政年份:2019
- 资助金额:
$ 68.28万 - 项目类别:
Operating Grants
Modelling Age- and Sex-related Changes in Gait Coordination Strategies in a Healthy Adult Population Using Principal Component Analysis
使用主成分分析对健康成年人群步态协调策略中与年龄和性别相关的变化进行建模
- 批准号:
430871 - 财政年份:2019
- 资助金额:
$ 68.28万 - 项目类别:
Studentship Programs
Transplantation of Adult, Tissue-Specific RPE Stem Cells as Therapy for Non-exudative Age-Related Macular Degeneration AMD
成人组织特异性 RPE 干细胞移植治疗非渗出性年龄相关性黄斑变性 AMD
- 批准号:
9811094 - 财政年份:2019
- 资助金额:
$ 68.28万 - 项目类别:
Study of pathogenic mechanism of age-dependent chromosome translocation in adult acute lymphoblastic leukemia
成人急性淋巴细胞白血病年龄依赖性染色体易位发病机制研究
- 批准号:
18K16103 - 财政年份:2018
- 资助金额:
$ 68.28万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Doctoral Dissertation Research: Literacy Effects on Language Acquisition and Sentence Processing in Adult L1 and School-Age Heritage Speakers of Spanish
博士论文研究:识字对西班牙语成人母语和学龄传统使用者语言习得和句子处理的影响
- 批准号:
1823881 - 财政年份:2018
- 资助金额:
$ 68.28万 - 项目类别:
Standard Grant
Adult Age-differences in Auditory Selective Attention: The Interplay of Norepinephrine and Rhythmic Neural Activity
成人听觉选择性注意的年龄差异:去甲肾上腺素与节律神经活动的相互作用
- 批准号:
369385245 - 财政年份:2017
- 资助金额:
$ 68.28万 - 项目类别:
Research Grants