Imaging Core

成像核心 总结 神经影像信息学和分析中心（NIAC）成像核心的主要目标是 通过提供实践专业知识，MRI物理学， 开发和支持，以及先进的分析软件平台。这些功能将提供给所有 WashU研究人员，但特别关注临床研究人员和新手研究人员， 缺乏将神经影像学方法应用于研究的专业知识。作为次要目标，我们将 促进先进的神经影像学方法转化为临床诊断实践在华盛顿大学- 附属医院。通过Aim 1，Core将为WashU神经科学提供图像采集指导 研究社区，包括通过标准NIAC采集协议（SNAP），详细 规范先进的MRI序列，可方便地用于基础和临床的广泛范围 research. SNAP包括最先进的序列，包括高分辨率解剖扫描和多功能扫描。 带状短回波时间功能磁共振成像和弥散纤维束成像。一套标准化的分析 将开发和支持各种方法，以简化SNAP和下一代 扫描仪现在部署在华盛顿大学在目标2中，核心将支持开发和验证新的 利用高梯度强度MRI扫描仪前所未有的功能的图像序列， 同步PET/MRI扫描仪。这些方法包括扩散基频谱成像、多波段回波 平面成像和扩散光学层析成像。成像核心的分析软件平台将是 扩展，使这些先进的设备和采集方法的有效使用，我们的工作人员将 告知研究者其优点，并将通过将其纳入 SNAP。最后，通过目标3，核心将扩展其成像和分析方法，以支持 先进的神经影像学方法。核心将与行政和信息学 中心范围内的核心交叉工作，以实施临床翻译框架，包括 由Imaging Core开发的自动化图像处理和质量控制分析管道， 部署在由Informatics Core运营的翻译成像平台（TIP）上。我们将合作 与中心研究人员一起验证方法，因为它们被转换并转移到常规患者护理中。

Imaging Core Summary The principal objective of the Neuroimaging Informatics and Analysis Center (NIAC) Imaging Core is to enhance the research of NIAC-supported investigators by providing hands-on expertise, MRI physics development and support, and an advanced analysis software platform. These functions will be provided to all WashU investigators, but with a particular focus on clinical researchers and novice investigators who otherwise lack the expertise to adopt neuroimaging methods into their research. As a secondary objective, we will facilitate the translation of advanced neuroimaging methods into clinical diagnostic practices at WashU- affiliated hospitals. With Aim 1, the Core will provide image acquisition guidance to the WashU neuroscience research community, including through the Standard NIAC Acquisition Protocol (SNAP), a detailed specification of advanced MRI sequences that can be readily used in a wide spectrum of basic and clinical research. The SNAP includes state-of-the-art sequences, including high-resolution anatomic scans and multi- band short echo time functional MRI and diffusion tractography imaging. A standardized suite of analysis methods will be developed and supported to enable streamlined use of the SNAP and next generation scanners now deployed at WashU. With Aim 2, the core will support the development and validation of new image sequences that leverage the unprecedented capabilities of the high gradient strength MRI scanners and simultaneous PET/MRI scanner. These methods include diffusion basis spectrum imaging, multi-band echo planar imaging, and diffuse optical tomography. The Imaging Core's analysis software platform will be extended to enable the effective use of these advanced devices and acquisition methods, and our staff will inform investigators of their advantages and will guide investigators in their use by incorporating them into the SNAP. Finally, with Aim 3, the Core will extend its imaging and analytic methods to support translation of advanced neuroimaging methods to the clinic. The Core will partner with the Administrative and Informatics Cores in a Center-wide crosscutting effort to implement a clinical translation framework that includes automated image processing and quality control analytics pipelines developed by the Imaging Core and deployed on the Translational Imaging Platform (TIP) operated by the Informatics Core. We will collaborate with Center investigators to validate methods as they are translated and moved to routine patient care.