Investigating Obesity and Chronic Disease-Related Risk Factors of Alaska Natives

调查阿拉斯加原住民的肥胖和慢性病相关危险因素

• 批准号: 9085302
• 负责人: Diane Marie O'Brien
• 金额: $ 99.72万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9085302
• 关键词: Achievement; Address; Adopted; Advisory Committees; Alaska; Alaska Native; Americas; Area; Award; Awareness; Behavioral Genetics; Businesses; Capital; Centers of Research Excellence; Chronic Disease; Clinical Research; Committee Members; Communication; Communities; Community Relations; Comorbidity; Consultations; Core Facility; Development; Disease; Ensure; Ethics; Evidence based practice; Evolution; Extramural Activities; Faculty; Fees; Fostering; Funding; Future; Goals; Grant; Health; Health Policy; Incidence; Income; Individual; Institution; Interdisciplinary Study; Intervention; Intervention Studies; Investments; Laboratories; Lead; Leadership; Learning; Mentors; Metabolic Diseases; Minority; Names; Native-Born; Nutritional; Obesity; Outcomes Research; Participant; Personal Satisfaction; Phase; Pilot Projects; Population; Prevention; Preventive treatment; Process; Publications; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Risk Factors; Rural; Scientist; Source; Strategic Planning; Substance abuse problem; Suicide; Testing; Translational Research; Trust; United States National Institutes of Health; Universities; Work; Youth; base; community based participatory research; community building; community partnership; design; disorder risk; evidence base; experience; health disparity; improved; innovation; member; minority health; next generation; obesity treatment; professor; programs; ranpirnase; social; success; training opportunity; tribal community

The Center for Alaska Native Health Research (CANHR), established in 2001 with COBRE I support, has become nationally recognized for both the quality of its research to reduce disease and promote health among Alaska Native (AN) people and for Community-Based Participatory Research (CBPR) with minority populations. AN people have been engaged in all phases of CANHR research, including setting CANHR's current research agenda on obesity and metabolic disease. The evolution and solidification of this decade-long community partnership has expanded this research agenda into intervention research aimed at prevention and treatment of obesity and metabolic disease, youth suicide, and substance abuse. CANHR funding has increased from one NIH grant in 2001, to nearly $5M in 2010. With support from an NIH construction grant, we are building the first two clinical research laboratories in the state of Alaska, while increasing our net space by over 5,000 sq. ft. The University of Alaska Fairbanks leadership has increased its already substantial commitment to CANHR, further augmenting our research expertise with new faculty hires and consultation from nationally recognized senior researchers through the President's Professors program. Our publication rate continues to increase, surpassing 100 publications in the past four years. The goal of the proposed COBRE Phase III Transitional Center is to solidify these achievements with a focus on transitioning CANHR into a self-supporting, sustainable, nationally recognized research center focused on AN health and CBPR. We propose to do this by: (1) strengthening the infrastructure of core resources to support research and community engagement; (2) expanding mentoring and training opportunities to develop the next generation of AN health researchers; (3) developing an innovative Pilot Project program (External Partnerships for Specific Expertise), to foster collaborative research with scientific leaders at research-intensive institutions that, in our experience, will p9sitively impact our extramural funding success; (4) continuing the President's Professors Program to expand intellectual capital and national recognition of CANHR; and (5) including a comprehensive business plan to ensure income to sustain CANHR cores.

2001年在科布雷I的支持下成立的阿拉斯加土著健康研究中心(CANHR)因其减少疾病和促进阿拉斯加土著(AN)健康的研究质量和少数群体社区参与性研究(CBPR)而获得全国认可。一个人参与了CANHR研究的所有阶段，包括制定CANHR目前关于肥胖和代谢性疾病的研究议程。这种长达十年的社区伙伴关系的发展和巩固，将这一研究议程扩展到旨在预防和治疗肥胖症和代谢性疾病、青少年自杀和药物滥用的干预研究。CANHR的资金已从2001年的一笔NIH拨款增加到2010年的近500万美元。在NIH建设赠款的支持下，我们正在建设阿拉斯加州的头两个临床研究实验室，同时将我们的净面积增加了5000多平方米。英国《金融时报》阿拉斯加大学费尔班克斯大学领导层增加了对CANHR的重大承诺，通过招聘新教师和通过总统教授计划向全国公认的高级研究人员提供咨询，进一步增强了我们的研究专业知识。我们的发表率不断提高，在过去的四年里已经超过了100种。拟议中的科布雷第三阶段过渡中心的目标是巩固这些成就，重点是将CANHR转变为一个自给自足、可持续的、国家认可的、专注于健康和CBPR的研究中心。我们建议通过：(1)加强核心资源的基础设施，以支持研究和社区参与；(2)扩大指导和培训机会，以培养下一代健康研究人员；(3)制定创新的试点项目计划(特定专业知识的外部伙伴关系)，以促进与研究密集型机构的科学领导者的合作研究，根据我们的经验，这些研究将对我们的外部资助成功产生积极影响；(4)继续校长的教授计划，以扩大智力资本和国家对CANHR的认可；以及(5)包括一项全面的商业计划，以确保维持CANHR核心的收入。

项目成果

Culturally adapting an evidence-based intervention to promote a healthy diet and lifestyle for Yup'ik Alaska native communities.

• DOI: 10.1080/22423982.2022.2159888
• 发表时间: 2023-12
• 期刊: INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
• 影响因子: 1.3
• 作者: Hopkins, Scarlett E.;Orr, Eliza;Boyer, Bert B.;Thompson, Beti
• 通讯作者: Thompson, Beti

Exercise Increases Glucose Transporter-4 Levels on Peripheral Blood Mononuclear Cells.

• DOI: 10.1249/mss.0000000000001528
• 发表时间: 2018-05
• 期刊: Medicine and science in sports and exercise
• 影响因子: 4.1
• 作者: Sticka KD;Schnurr TM;Jerome SP;Dajles A;Reynolds AJ;Duffy LK;Knall CM;Dunlap KL
• 通讯作者: Dunlap KL

The loss of hemoglobin and myoglobin does not minimize oxidative stress in Antarctic icefishes.

血红蛋白和肌红蛋白的损失并不能最大限度地减少南极冰鱼的氧化应激。

• DOI: 10.1242/jeb.162503
• 发表时间: 2018
• 期刊: The Journal of experimental biology
• 作者: O'Brien,KristinM;Crockett,ElizabethL;Philip,Jacques;Oldham,CoreyA;Hoffman,Megan;Kuhn,DonaldE;Barry,Ronald;McLaughlin,Jessica
• 通讯作者: McLaughlin,Jessica