Mentoring Junior Investigators: Comprehensive HIV Prevention

指导初级研究者：全面的艾滋病毒预防

• 批准号: 9079284
• 负责人: CAROL E GOLIN
• 金额: $ 15.79万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-17 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9079284
• 关键词: AIDS prevention; AIDS/HIV problem; Achievement; Address; Adherence; Affect; Behavior; Behavior Therapy; Behavioral; Caring; Censuses; Collaborations; Communication; Communities; Crime; Data; Development; Diagnosis; Disease Progression; Education; Effectiveness; Epidemic; Food; Gender; Generations; Goals; HIV; HIV prevention trials network; HIV risk; Health; Health Care Costs; Health Services Accessibility; Health behavior; Heterosexuals; Imprisonment; Incidence; Individual; Infection; International; Intervention; Interview; Investigation; K-Series Research Career Programs; Life; Low income; Mentors; Midcareer Investigator Award in Patient-Oriented Research; Minority; Motivation; Neighborhoods; North Carolina; Observational Study; Participant; Poverty; Prevalence; Prevention; Prevention program; Preventive Intervention; Program Effectiveness; Public Health; Research; Research Personnel; Risk; Risk Behaviors; Risk Reduction; Role; Rosa; Safe Sex; Self Efficacy; Single-Parent Family; Social Network; Stress; Testing; Time; Training; Underrepresented Groups; Unsafe Sex; Viral Load result; Woman; Work; arm; base; behavioral/social science; career; career development; condoms; contextual factors; cost; cost effectiveness; high risk; high risk sexual behavior; housing instability; improved; innovation; interest; intervention program; literacy; male; medication compliance; meetings; member; motivational enhancement therapy; patient oriented; patient oriented research; prevent; programs; public health relevance; response; skills; social norm; social stigma; standard care; transmission process; treatment program

DESCRIPTION (provided by applicant): This is a proposal for a midcareer investigator award in patient-oriented research (K24) for Dr. Carol Golin. Despite efforts to curb HIV spread, incidence continues to increase in the southern U.S. Behavioral programs that address risky sexual behavior and ARV adherence can improve HIV transmission-related health behaviors of individuals, but are limited. Interpersonal and community-level factors, such poverty, social norms, crime and incarceration rates, interpersonal stress, and dyadic capacity often drive or constrain vulnerability to HIV, and may impede effects of behavioral programs. There is an urgent need for a pipeline of beginning investigators, especially those from underrepresented groups, with the interest and skills to collaboratively address these factors. As Director of the UNC CFAR Social and Behavioral Science Core, Dr. Golin is increasingly called upon to mentor numerous promising young investigators seeking to work with her to obtain such skills. The proposed career development award will give Dr. Golin the dedicated time to expand and build her patient- oriented research in HIV/AIDS prevention by mentoring several talented junior colleagues at UNC in HIV prevention and adherence research. Dr. Golin aims to create a formal UNC Program on HIV Prevention in the US South by achieving four immediate goals, to: 1) enhance her capacity to evaluate structural determinants of health and cost-effectiveness of HIV prevention intervention programs through formal and informal training and collaboration; 2) extend her patient-oriented investigations (exploring the interface between motivation, self- efficacy, and risky sexual behavior) by examining the role of interpersonal and community-level determinants of the HIV epidemic in influencing the effectiveness of HIV prevention programs; 3) evaluate the cost- effectiveness of the "Individuals Motivated to Participate and Adhere to Care and Treatment" (imPACT) HIV prevention program; and 4) enhance her capacity to provide effective and outstanding mentoring to junior investigators. The patient-oriented research proposed in this application, which provides a vehicle for career development for Dr. Golin and her mentees, will: 1) Examine the moderating effects of interpersonal and structural factors on the SafeTalk program's effectiveness among heterosexual HIV-infected individuals; 2) Explore the views of heterosexual participants in the imPACT study and their social network members to assess dyadic and community factors that helped or impeded their use of adherence or safer sex strategies.; 3) Evaluate the cost-effectiveness of the imPACT program; 4) Explore potential neighborhood and dyadic contexts for HIV risk among HIV-negative women and their male partners living in high poverty, high HIV prevalence census tracts in in NC. Her long-term career objective is to grow the HIV Prevention Program she is developing to a fully established Center for creating, testing, and disseminating effective, comprehensive HIV prevention interventions for vulnerable communities throughout the Southeastern U.S.

描述（由申请人提供）：这是一个职业中期研究者奖的建议，以病人为导向的研究（K24）博士卡罗尔戈林。尽管努力遏制艾滋病毒的传播，发病率继续增加，在美国南部的行为方案，解决危险的性行为和抗逆转录病毒药物依从性可以改善艾滋病毒传播相关的健康行为的个人，但是有限的。人际关系和社区层面的因素，如贫困，社会规范，犯罪和监禁率，人际压力和二元能力往往驱动或限制对艾滋病毒的脆弱性，并可能阻碍行为计划的影响。目前迫切需要一批具有合作解决这些因素的兴趣和技能的初级调查人员，特别是来自代表性不足群体的调查人员。Golin越来越多地被要求指导许多有前途的年轻调查人员寻求与她合作，以获得这些技能。拟议的职业发展奖将使戈林博士有专门的时间来扩大和建立她的艾滋病毒/艾滋病预防以病人为导向的研究，指导几个有才华的初级同事在艾滋病毒预防和坚持研究。Golin博士旨在通过实现四个直接目标，在美国南部建立一个正式的艾滋病预防计划，以：1）通过正式和非正式的培训和合作，提高她评估健康和艾滋病预防干预计划的成本效益的结构性决定因素的能力;（2）扩大以病人为中心的调查（探讨动机，自我效能，和危险的性行为），通过审查艾滋病毒流行的人际和社区一级的决定因素在影响艾滋病毒预防方案的有效性方面的作用; 3）评估“有动力参与和坚持护理和治疗的个人”（imPACT）艾滋病毒预防方案的成本效益; 4）提高她为初级研究人员提供有效和出色指导的能力。本申请中提出的以患者为导向的研究为Golin博士和她的学员提供了职业发展的工具，将：1）检查人际和结构因素对SafeTalk计划在异性恋艾滋病毒感染者中的有效性的调节作用;（二）探索imPACT研究中的异性恋参与者及其社交网络成员的观点，以评估帮助他们的二元和社区因素。或阻碍他们使用坚持或更安全的性行为策略。3)评估imPACT计划的成本效益; 4）在北卡罗来纳州生活在高度贫困、艾滋病毒高流行率人口普查区的艾滋病毒阴性妇女及其男性伴侣中，探索潜在的邻里和二元背景下的艾滋病毒风险。她的长期职业目标是将她正在开发的艾滋病预防计划发展成为一个完全建立的中心，为整个美国东南部的弱势社区创建，测试和传播有效，全面的艾滋病预防干预措施。