Liver Disease and HIV

肝病和艾滋病毒

• 批准号: 8990913
• 负责人: KENNETH E SHERMAN
• 金额: $ 4万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8990913
• 关键词: Acceleration; Address; Aflatoxins; Alcohols; Anti-Retroviral Agents; Area; Attention; Award; Chronic; Cirrhosis; Collaborations; Communicable Diseases; Communication; Complex; Data; Development; Diagnosis; Discipline; Drug Interactions; Environmental Exposure; Etiology; Faculty; Food Supply; Functional disorder; Grant; HIV; Health; Hepatitis B; Hepatitis B Virus; Hepatitis C virus; Hepatology; Hepatotoxicity; Individual; Injury; Injury to Liver; International; Life; Life Expectancy; Liver; Liver Fibrosis; Liver diseases; Malignant neoplasm of liver; Manuscripts; Medicine; Morbidity - disease rate; Natural History; Online Systems; Opportunistic Infections; Outcome; Participant; Patients; Peer Review; Persons; Pharmaceutical Preparations; Pharmacology; Population; Portal Hypertension; Probability; Process; Professional Organizations; Psychiatry; Publications; Publishing; Research; Research Personnel; Resources; Risk; Scholarship; Series; Site; Specialist; Staging; Virus Diseases; addiction; authority; continuing medical education; cytokine; design; disorder risk; grasp; improved; innovation; liver development; medical specialties; meetings; mortality; multidisciplinary; programs; public health relevance; stellate cell; symposium

 DESCRIPTION (provided by the applicant): Liver disease is major contributor to morbidity/mortality among those with HIV. The etiologies of liver disease include hepatitis C virus (HCV) and hepatitis B virus (HBV) infection as well as drug-induced liver toxicity. Direct and indirect effects of HIV on stellate cell activation, and on alteration of the cytokine milieu i the liver contribute to injury. Research and information sharing remain fragmented along specialty lines. In an ongoing effort to improve communication, stimulate the research agenda, and develop new productive collaborations, we propose the continuation of a series of conferences on HIV and Liver Disease. The proposed conferences will take place over a three day period in 2016, and 2018 which will bring together leading experts in the field including those in Infectious Diseases, Hepatology, Addiction Medicine, Pharmacology and Psychiatry. In addition, young investigators and trainees will be encouraged to attend via a scholarship mechanism supported by this grant. Meeting outcomes include provision of continuing medical education credit, development of a published manuscript on the subject, and possibly the creation of a web-based educational site. Particular attention will be paid to development of new research concepts and establishment of collaborative associations by participants.

 描述(由申请人提供)：肝脏疾病是艾滋病毒携带者发病率/死亡率的主要因素。肝病的病因包括丙型肝炎病毒(丙型肝炎病毒)和乙肝病毒(乙肝病毒)感染以及药物所致的肝毒性。HIV对星状细胞激活的直接和间接影响，以及对细胞因子环境的改变，都会导致肝脏损伤。研究和信息共享仍然分散在专业领域。为了不断努力改善沟通，刺激研究议程，并发展新的富有成效的合作，我们建议继续举办一系列关于艾滋病毒和肝病的会议。拟议的会议将在2016年和2018年举行，为期三天，届时将汇集该领域的领先专家，包括传染病、肝病、成瘾医学、药理学和精神病学方面的专家。此外，将鼓励年轻的研究人员和受训人员通过由这笔赠款支持的奖学金机制参加。会议成果包括提供继续医学教育学分，编写关于这一主题的出版手稿，并可能创建一个基于网络的教育网站。与会者将特别注意发展新的研究概念和建立协作协会。