Liver Disease and HIV

描述（由申请人提供）：肝病是HIV感染者发病率/死亡率的主要因素。肝病的病因包括丙型肝炎病毒（HCV）和B肝炎病毒（HBV）感染以及药物诱导的肝毒性。HIV对星状细胞活化的直接作用和对肝脏中细胞因子环境的改变促成损伤。研究和信息共享仍然沿着专业线分散。在不断努力改善沟通，刺激研究议程，并开发新的富有成效的合作，我们建议继续举办一系列关于艾滋病毒和肝病的国家/国际会议。拟议的会议将于2012年和2014年举行，为期三天，将汇集该领域的主要专家。此外，将鼓励年轻的调查员和受训人员通过该赠款支持的奖学金机制参加。会议成果包括提供继续医学教育学分，开发关于该主题的出版手稿，以及提供基于网络的教育网站。将特别注意发展新的研究概念和建立参与者的合作协会。

DESCRIPTION (provided by applicant): Liver disease is a major contributor to morbidity/mortality among those with HIV. The etiologies of liver disease include hepatitis C virus (HCV) and hepatitis B virus (HBV) infection as well as drug-induced liver toxicity. Direct effects of HIV on stellate cell activation, and on alteration of the cytokine milieu in the liver contribute to injury. Research and information sharing remain fragmented along specialty lines. In an ongoing effort to improve communication, stimulate the research agenda, and develop new productive collaborations, we propose the continuation of a series of national/international conferences on HIV and liver disease. The proposed conferences will take place over a three day period in 2012, and 2014 which will bring together leading experts in the field. In addition, young investigators and trainees will be encouraged to attend via a scholarship mechanism supported by this grant. Meeting outcomes include provision of continuing medical education credit, development of a published manuscript on the subject, and the availability of a web-based educational site. Particular attention will be paid to development of new research concepts and establishment of collaborative associations by participants.