课题基金 / 基金详情

HIV Antiretroviral Therapy and Hepatic Injury

HIV Antiretroviral Therapy and Hepatic Injury
HIV 抗逆转录病毒治疗和肝损伤
批准号:
9139029
负责人:
KENNETH E SHERMAN
金额:
$56.27万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-04-15 至 2020-01-31

项目摘要

项目成果

KENNETH E SHERMAN的其他基金

相似基金

相关文献

中文摘要
翻译

英文摘要
 DESCRIPTION (provided by applicant): The causes of liver disease are complex and include chronic viral hepatitis (B,C,D), alcohol, drug-associated hepatotoxicities and metabolic disorders. However, fibrosis leading to cirrhosis and end-stage liver disease is the common pathway for hepatic injury. Rates of fibrotic progression are highly variable, and reflect differences in host response to disease. One host factor, a chemokine receptor named CCR5 may play a central role in modulating hepatic fibrosis, and will be the primary subject of exploration in this study. We will examine the effects of CCR5 deletion mutations (CCR5- ∆32) in a large and well- characterized cohort of patients with hemophilia who were followed for up to 18 years in the NIH Multicenter Hemophilia Cohort Studies (MHCS). In addition we will utilize samples derived from a study of HIV-infected patients treated with a unique CCR5/CCR2 inhibitor, Cenicriviroc. In Specific Aim 1 we will characterize the effect of CCR5 on in vivo hepatic fibrogenesis, focusing on both intrinsic (gene polymorphism) and extrinsic (CVC) associated CCR5 blockade. Specific Aim 2 will examine the immune regulatory mechanisms which may affect fibrosis development in relation to CCR5 mutation or blockade using both lymphocytes and liver tissue. Specific Aim 3 will utilize in vivo methods to characterize the effec of CCR5 antagonism on HCV and the immune environment. Using RNAseq and other experimental methods we will determine the pathway(s) involved with modulation of HCV replication and hepatic fibrogenesis. We hypothesize that either host mutation in CCR5 coding genes or pharmacologic blockade will reduce hepatic fibrosis and will attempt to elucidate the mechanism(s) by which this occurs. This study may generate new paradigms for prevention of hepatic fibrosis in those with HIV infection.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Biomarkers of Replication and Injury in HBV/HIV
  • 批准号:
    10449351
  • 项目类别:
  • 资助金额:
    $20.73万
  • 财政年份:
    2021
  • 负责人:
    KENNETH E SHERMAN
  • 依托单位:
Biomarkers of Replication and Injury in HBV/HIV
  • 批准号:
    10326569
  • 项目类别:
  • 资助金额:
    $23.67万
  • 财政年份:
    2021
  • 负责人:
    KENNETH E SHERMAN
  • 依托单位:
Hepatitis E in HIV-Infected Patients
  • 批准号:
    9335720
  • 项目类别:
  • 资助金额:
    $27.5万
  • 财政年份:
    2015
  • 负责人:
    KENNETH E SHERMAN
  • 依托单位:
Hepatitis E in HIV-Infected Patients
  • 批准号:
    9049750
  • 项目类别:
  • 资助金额:
    $27.5万
  • 财政年份:
    2015
  • 负责人:
    KENNETH E SHERMAN
  • 依托单位:
海外基金