Mentorship in Liver Disease

肝病已成为美国发病率和死亡率的主要来源，在一些可识别的组中具有不成比例的代表性。此外，独特的管理和治疗问题与被称为“特殊人群”的可识别群体有关。这个K-24申请证明了候选人对特殊人群肝脏疾病的关注，包括血友病患者，肝移植接受者，酗酒者和艾滋病毒感染者。进行性肝病的病因是多因素的，包括病毒性肝炎、药物毒性（包括与高效抗逆转录病毒疗法（HAART）相关的药物毒性）、酒精和不同水平的免疫抑制。证据提供，候选人是装备精良，以提供指导的初级教师和学员在他的方案目标的范围内。该提案包括：1。描述候选人对以患者为导向的研究的承诺。一个导师计划，结合教学培训，学员和初级教师参与正在进行的研究活动，以及候选人和学员之间的持续互动，以发展新生的病人为基础的研究事业的要素的关键方面的表征。3.审查由NIH和制药行业资助的特定研究活动，作为面向患者的研究的结构框架

Liver disease has emerged as a major source of morbidity and mortality in the United States with a disproportionate representation in some identifiable groups. Furthermore, unique management and treatment issues are associated with identifiable groups which have been characterized as "special populations". This K-24 application demonstrates the candidate's focus on liver disease in special populations including hemophiliacs, liver transplant recipients, alcoholics and individuals with HIV infection. The etiologies of progressive liver disease are multifactorial and include viral hepatitis, drug toxicities including those associated with highly active antiretroviral therapies (HAART), alcohol, and variable levels of immunosuppression. Evidence is provided that the candidate is well equipped to provide mentorship of junior faculty and trainees within the context of his programmatic goals. This proposal includes a: 1.Description of the candidate's commitment to patient-oriented research 2. Characterization of key aspects of a mentorship program that incorporates elements of didactic training, involvement of trainees and junior faculty in ongoing research activities, and ongoing interaction between candidate and mentee to develop nascent patient based research careers. 3. Review of the specific research activities funded by NIH and the pharmaceutical industry that serve as a structural framework for patient-oriented research