TBD

待定

• 批准号: 10308489
• 负责人: Shuzhao Li
• 金额: $ 46.83万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10308489
• 关键词: Antibodies; Attenuated; Biological Assay; Cells; Communicable Diseases; Data; Data Analyses; Early identification; Gene Combinations; Gene Expression; Genes; Herpes zoster disease; Human; Immune; Immune response; Immunology; Individual; Infection; Inositol Phosphate Metabolism Pathway; Learning; Lipids; Measurement; Measures; Metabolic; Metabolic Pathway; Methods; Molecular; Participant; Pathway interactions; Pattern; Peripheral Blood Mononuclear Cell; Plasma; Public Health; Regulation; Reporting; Research; Sampling; Signal Transduction; T cell response; Testing; Therapeutic; Time; Vaccination; Vaccines; Work; Zoster Vaccine; adaptive immune response; base; cancer immunotherapy; chemical group; cohort; design; fighting; improved; individual response; individual variation; insight; lipidomics; metabolic phenotype; metabolomics; multiple omics; predictive modeling; public health relevance; response; sample archive; single-cell RNA sequencing; small molecule; small molecule libraries; steroid metabolism; tool; transcriptomics; vaccine development; vaccine trial; vaccine-induced immunity

Abstract Understanding immunometabolism at the systemic level is important to vaccine development and cancer immunotherapy. While new data are coming out, methodical measurements of small molecules using metabolomics are still limited. Our team recently reported a multi-omics study of herpes zoster vaccine (Zostavax), which identified major metabolic influences to vaccine induced immunity, including inositol phosphate metabolism and steroid metabolism. To fully test the metabolite predictors of immune responses, we have acquired samples from a larger Zostavax study, and propose to perform advanced, high-coverage metabolomics analysis. Predictive models of immune responses will be developed on one cohort and tested on the other. These data will also be compared to a newer and more efficacious zoster vaccine. Together, this study will establish how metabolite profiles determine the immune responses of individuals.

摘要 了解系统水平的免疫代谢对疫苗开发很重要 和癌症免疫疗法。虽然新的数据正在出现，但对小规模的系统测量 使用代谢组学的分子仍然有限。我们的团队最近报道了一项多组学研究 带状疱疹疫苗（Zostavax），确定了对疫苗的主要代谢影响 诱导免疫，包括肌醇磷酸代谢和类固醇代谢。全面测试 作为免疫反应的代谢物预测因子，我们已经从一个更大的 Zostavax研究，并建议进行先进的，高覆盖率的代谢组学分析。 将在一个队列中开发免疫应答的预测模型，并在 其他.这些数据也将与更新和更有效的带状疱疹疫苗进行比较。 总之，这项研究将确定代谢产物谱如何决定免疫反应， 个体