TBD

待定

• 批准号: 10909541
• 负责人: Shuzhao Li
• 金额: $ 27.3万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10909541
• 关键词: Antibodies; Attenuated; Biological Assay; Cells; Communicable Diseases; Data; Data Analyses; Early identification; Gene Combinations; Gene Expression; Genes; Herpes zoster disease; Human; Immune; Immune response; Immunology; Individual; Infection; Inositol Phosphate Metabolism Pathway; Learning; Lipids; Measurement; Measures; Metabolic; Metabolic Pathway; Molecular; Participant; Pathway interactions; Pattern; Peripheral Blood Mononuclear Cell; Plasma; Public Health; Regulation; Reporting; Research; Sampling; Signal Transduction; T cell response; Testing; Therapeutic; Time; Vaccination; Vaccines; Work; Zoster Vaccine; adaptive immune response; cancer immunotherapy; chemical group; cohort; design; fighting; improved; individual response; individual variation; insight; lipidomics; metabolic phenotype; metabolomics; multiple omics; predictive modeling; public health relevance; response; sample archive; single-cell RNA sequencing; small molecule; small molecule libraries; steroid metabolism; tool; transcriptomics; vaccine development; vaccine trial; vaccine-induced immunity

Abstract Understanding immunometabolism at the systemic level is important to vaccine development and cancer immunotherapy. While new data are coming out, methodical measurements of small molecules using metabolomics are still limited. Our team recently reported a multi-omics study of herpes zoster vaccine (Zostavax), which identified major metabolic influences to vaccine induced immunity, including inositol phosphate metabolism and steroid metabolism. To fully test the metabolite predictors of immune responses, we have acquired samples from a larger Zostavax study, and propose to perform advanced, high-coverage metabolomics analysis. Predictive models of immune responses will be developed on one cohort and tested on the other. These data will also be compared to a newer and more efficacious zoster vaccine. Together, this study will establish how metabolite profiles determine the immune responses of individuals.

摘要