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Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut Microbiota

Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut Microbiota
减肥饮食对肠道菌群心脏代谢因素的干预
批准号:
10311104
负责人:
Lu Qi
金额:
$62.02万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-09-15 至 2024-11-30

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中文摘要
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摘要
英文摘要
Abstract Compelling evidence has implicated human gut microbiota in development of obesity and related cardiometabolic disorders. Recent studies identified a group of circulating metabolites that are functionally related to gut microbiota. These microbial metabolites act as ‘transducers’ in the microbiota-host communications and ‘sensors’ in gut-organ/tissue crosstalk, and affect ectopic fat distribution in various metabolic organs and tissues. Diet is among the most important regulators of gut microbiota; however, no study has assessed how weight-loss diets may affect the long-term changes of the newly identified microbial metabolites. The proposed systems study aims to fill this significant research gap. In two of the longest and largest comparator trials on the popular weight-loss diets - POUNDS LOST and CENTRAL, we propose to identify novel plasma microbial metabolites associated with long-term weight loss in response to diet interventions. We will examine relations of plasma levels of identified microbial metabolites and ectopic fat distribution in the liver, heart, pancreas, and kidney, as well as adipose and skeletal muscle tissues. In addition, we will assess whether changes in plasma microbial metabolites mediate the relations between weight loss and changes in cardiometabolic markers. Moreover, we will examine the dynamic associations between microbial metabolites and changes in plasma miRNAs related to obesity and cardiometabolic risk. The findings from our study will considerably improve development of novel prevention and treatment strategies for obesity and related cardiometabolic disorders.
期刊论文(6)
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会议论文
DOI: 10.1002/oby.23047
发表时间: 2021-01
期刊: Obesity (Silver Spring, Md.)
影响因子: --
作者: [Song Q, Wang L, Liu H, Liang Z, Chen Y, Sun D, Li W, Leng J, Yang X, Cardoso MA, Hu G, Qi L]
通讯作者: Qi L
DOI: 10.1136/bmj.i4707
发表时间: 2016-09-20
期刊: BMJ (Clinical research ed.)
影响因子: --
作者: [Livingstone KM, Celis-Morales C, Papandonatos GD, Erar B, Florez JC, Jablonski KA, Razquin C, Marti A, Heianza Y, Huang T, Sacks FM, Svendstrup M, Sui X, Church TS, Jääskeläinen T, Lindström J, Tuomilehto J, Uusitupa M, Rankinen T, Saris WH, Hansen T, Pedersen O, Astrup A, Sørensen TI, Qi L, Bray GA, Martinez-Gonzalez MA, Martinez JA, Franks PW, McCaffery JM, Lara J, Mathers JC]
通讯作者: Mathers JC
DOI: 10.1038/ijo.2017.28
发表时间: 2017-06
期刊: International journal of obesity (2005)
影响因子: --
作者: [Liu G, Liang L, Bray GA, Qi L, Hu FB, Rood J, Sacks FM, Sun Q]
通讯作者: Sun Q
Dietary Protein Modifies the Effect of the MC4R Genotype on 2-Year Changes in Appetite and Food Craving: The POUNDS Lost Trial.
膳食蛋白质改变 MC4R 基因型对食欲和食物渴望 2 年变化的影响:POUNDS Lost 试验。
DOI: 10.3945/jn.116.242958
发表时间: 2017
期刊: The Journal of nutrition
影响因子: --
作者: [Huang,Tao, Zheng,Yan, Hruby,Adela, Williamson,DonaldA, Bray,GeorgeA, Shen,Yiru, Sacks,FrankM, Qi,Lu]
通讯作者: Qi,Lu
Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions
  • 批准号:
    9425969
  • 项目类别:
  • 资助金额:
    $67.99万
  • 财政年份:
    2018
  • 负责人:
    Lu Qi
  • 依托单位:
Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions
  • 批准号:
    10620181
  • 项目类别:
  • 资助金额:
    $66.36万
  • 财政年份:
    2018
  • 负责人:
    Lu Qi
  • 依托单位:
Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions
  • 批准号:
    10445545
  • 项目类别:
  • 资助金额:
    $68.45万
  • 财政年份:
    2018
  • 负责人:
    Lu Qi
  • 依托单位:
Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions
  • 批准号:
    10080726
  • 项目类别:
  • 资助金额:
    $64.21万
  • 财政年份:
    2018
  • 负责人:
    Lu Qi
  • 依托单位:
海外基金