Dissecting the impact of forced displacement on Type Two Diabetes

剖析强迫流离失所对二型糖尿病的影响

• 批准号: 9791038
• 负责人: Lu Qi
• 金额: $ 15.31万
• 依托单位: LEBANESE AMERICAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-21 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9791038
• 关键词: Address; Adopted; Adult; Adverse effects; Affect; Age; American; Biometry; Chronic; Clinical; Clinical Psychology; Cohort Studies; Collaborations; Communicable Diseases; Complex; Conflict (Psychology); Country; Data; Dehydration; Development; Diabetes Mellitus; Diagnostic; Diet; Diet Habits; Disease; Ensure; Epidemiology; Genomics; Goals; Health; Health Sciences; Health system; High Prevalence; Individual; Inflammation; Insulin Resistance; Interdisciplinary Study; International; Lead; Lebanon; Life; Life Style; Link; Longitudinal cohort; Medical; Metabolic; Metabolic Diseases; Middle East; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Patients; Persons; Phenotype; Pilot Projects; Population; Population Genetics; Prediabetes syndrome; Prevention strategy; Primary Health Care; Prospective cohort; Public Health; Qi; Refugees; Research; Research Infrastructure; Research Personnel; Starvation; Stress; Syria; Testing; Universities; Variant; Violence; War; Woman; acute stress; analytical tool; care providers; cohort; diabetes risk; disorder risk; electronic registry; health care availability; high risk; holistic approach; improved; knowledge base; loved ones; low and middle-income countries; men; mortality; multidisciplinary; natural hypothermia; obesity prevention; patient population; patient registry; population health; programs; prospective; psychosocial; recruit; research study; social exclusion; stressor; treatment strategy; violence exposure

Abstract Currently, Lebanon has the highest per capita concentration of refugees in the world, where one in four persons in Lebanon is displaced from Syria. While several studies have focused on the occurrence of communicable diseases among refugees, data are extremely limited about the effects of forced displacement on chronic, noncommunicable diseases (NCDs) such as type 2 diabetes (T2D). We hypothesize that forced displacement leading to adverse changes in lifestyle is associated with T2D and other NCDs development. Our objective is to plan for the establishment of a sustainable collaborative research platform by building a unique prospective longitudinal cohort of individuals belonging to refugee and host population, providing opportunities to conduct a multitude of multidisciplinary studies investigating the short and long-term health effects of forced displacement on T2D. Accordingly the proposed project is not only relevant to an urgent and growing Low and Middle Income Countries (LMIC) priority, but will improve the capacity in the LMIC to conduct such research studies. We plan to achieve our objective by: 1) providing a detailed plan for establishing a prospective cohort that will include approximately 8,000 men and women with a wide age range, who will be recruited from a selected subset (n=70) of Primary Health Care Centers (PHCs) serving 49,023 patients including 7,733 Syrian refugees and 2) conducting a pilot study assessing the impact of forced displacement and adverse lifestyle changes on T2D development in a subset of refugee and host population patients. The proposed project would provide an ideal setting to apply analytic tools grounded with a life-stage, holistic approach and a multidisciplinary strategy that integrates epidemiology and population health sciences to advance our understanding of the determinants of T2D and other NCDs. The proposed project will prepare the research infrastructure (data, networking, capacity building) required for more comprehensive research programs that enhance the knowledge base and add to the long-term goals of sustainably strengthening research capacity in LMICs to address NCDs. Accordingly, it will result in better diagnostics, prevention, and treatment strategies.

抽象的 目前，黎巴嫩是世界上人均难民最集中的国家 黎巴嫩四分之一的人从叙利亚流离失所。虽然多项研究集中于 关于难民中传染病的发生情况，数据极其有限 关于被迫流离失所对慢性非传染性疾病（NCD）的影响，例如 2 型糖尿病 (T2D)。我们假设强迫流离失所会导致不利的结果 生活方式的改变与 T2D 和其他非传染性疾病的发展有关。我们的目标是 计划通过建立一个独特的、可持续的合作研究平台 属于难民和收容人口的个人的前瞻性纵向队列， 提供进行大量跨学科研究的机会 被迫流离失所对 T2D 的短期和长期健康影响。据此，建议 项目不仅与紧迫且不断增长的中低收入国家（LMIC）相关 优先事项，但将提高中低收入国家开展此类研究的能力。 我们计划通过以下方式实现我们的目标：1）提供建立前瞻性的详细计划 该队列将包括大约 8,000 名不同年龄层的男性和女性，他们将 从选定的初级卫生保健中心 (PHC) 子集 (n=70) 中招募 为 49,023 名患者提供服务，其中包括 7,733 名叙利亚难民；2) 开展试点研究 评估被迫流离失所和不良生活方式改变对 T2D 的影响 难民和收容人口患者的一部分的发展。拟议的项目将 提供理想的环境来应用基于生命阶段整体方法的分析工具 以及整合流行病学和人口健康科学的多学科战略 增进我们对 T2D 和其他非传染性疾病决定因素的理解。 拟议项目将准备研究基础设施（数据、网络、能力 建筑）需要更全面的研究计划来增强知识 为可持续加强中低收入国家研究能力的长期目标奠定基础并加以补充 解决非传染性疾病。因此，它将带来更好的诊断、预防和治疗 策略。