Impact of microbiota-mediated biotransformation of black tea polyphenols
微生物介导的红茶多酚生物转化的影响
基本信息
- 批准号:9398095
- 负责人:
- 金额:$ 41.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAcidsAddressAnimalsAnti-inflammatoryApoptosisBacteriaBeveragesBilateralBiologicalBiological AvailabilityBiological ProcessBiotaBlack TeaCancer EtiologyCatechinCell ProliferationCessation of lifeChemopreventive AgentColitis associated colorectal cancerColonic NeoplasmsColorectal CancerComplexConsumptionDataDevelopmentDiagnosisDietDrug KineticsEconomic BurdenEnterococcus faecalisEnvironmental Risk FactorEscherichia coliExcretory functionFoodGallic acidGenerationsGerm-FreeGnotobioticGoalsHealthHealth BenefitHeart DiseasesHourHouse miceIn VitroIndividualInflammatory Bowel DiseasesIntestinesKnowledgeLocationMalignant NeoplasmsMeasuresMediatingMetabolicMetabolic BiotransformationMetabolismMicrobeModelingMolecular WeightMono-SMucous MembraneMusOralOrganOrganismPathologyPatientsPlasmaPlayPolymersPositioning AttributePreventiveProcessProductionReportingResourcesRibosomal RNARoleSamplingSignal TransductionSystemTeaTheaflavinsTherapeuticTissuesUnited StatesUrineWild Type MouseWomanabsorptioncancer preventioncolon cancer cell linecommensal bacteriacostdimerenzyme activityexpectationgerm free conditiongut microbiotahuman microbiotaimprovedinflammatory markerinsightintestinal homeostasisliquid chromatography mass spectrometrymedical complicationmenmetabolomicsmicrobialmicrobial communitymicrobiome researchmicrobiotamicroorganismnovelphenolic acidpolyphenolpreventpublic health relevancetherapeutic targettranscriptome sequencing
项目摘要
DESCRIPTION (provided by applicant): Tea is one of the most widely consumed beverages in the world, with black tea accounting for 78% of the production. Consumption of tea has been associated with many health benefits including the prevention of cancer and heart disease. These effects have been attributed to the polyphenol compounds present in tea. Numerous studies have shown that tea polyphenols including catechins, their dimers (theaflavins) and polymers (thearubigins), have anti-inflammatory and cancer preventive activities. However, theaflavins and thearubigins, the major polyphenols in black tea, have poor systematic bioavailability. Therefore, it is still unclear how these compounds could exert their biological functions. Studies have shown that higher molecular weight polyphenols are metabolized by the microbiota and their metabolites may play an important role in black tea chemopreventive action. Ring-fission products and lower molecular weight phenolic acids have been identified as the major bacterial metabolites of catechins. However, the bacterial metabolites of theaflavins and thearubigins are still unknown. Our preliminary data indicate that microbial-derived metabolites are generated from the tea polyphenol thearubigins. Our central hypothesis is that the microbiota influence the generation of black tea polyphenol-derived metabolites enhancing their bioavailability and biological activities. The goal of this project is to determine the crosstalk between bacteria and polyphenol metabolism and establish the functional consequences on development of colitis-associated colorectal cancer. Our specific aims are as follows: 1) Determine the impact of the selective microbiota on biotransformation and pharmacokinetics of black tea polyphenol-derived metabolites. 2) Determine the relationship between microbial-derived metabolites and the biological action of black tea polyphenols/metabolites in colitis-associated colorectal cancer. 3) Measure the impact of black tea polyphenols on microbial community composition and activities. This project will determine the impact of the microbiota on black tea polyphenol- mediated biological effect in Il10-/- mice. Since the microbial community is variable among individuals, our findings will provide novel insight into how the biological activity of a defined dietary product could be altered by microorganisms. This knowledge could be utilized to improve biotransformation of active food products and to enhance their biological activity in various organs including the intestine. In addition, the basic
knowledge gained from the interplay between microorganisms and dietary-derived metabolite productions could uncover novel enzymes activity and therapeutic targets.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christian Jobin其他文献
Christian Jobin的其他文献
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Impact of microbiota-mediated biotransformation of black tea polyphenols
微生物介导的红茶多酚生物转化的影响
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Impact of microbiota-mediated biotransformation of black tea polyphenols
微生物介导的红茶多酚生物转化的影响
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