Circadian and sleep mechanisms among racial groups for nicotine dependence, craving, and withdrawal

不同种族群体对尼古丁依赖、渴望和戒断的昼夜节律和睡眠机制

• 批准号: 10351944
• 负责人: Karen L Cropsey
• 金额: $ 5.81万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10351944
• 关键词: Acute; Address; Administrative Supplement; Adult; Affect; Alabama; Alcohol consumption; Alcohols; Beds; Cause of Death; Cellular Phone; Characteristics; Cigarette; Circadian Dysregulation; Circadian Rhythms; Clinical Psychology; Data; Development; Drowsiness; Drug usage; Ecological momentary assessment; Education; Educational Activities; Ethnic Origin; Excessive Daytime Sleepiness; Exhibits; Gambling; Goals; Health; Hour; Individual; Inflammation; Intervention; Investigation; Knowledge; Lead; Learning; Light; Link; Measures; Mediating; Mediation; Medical; Medical Care Costs; Melatonin; Memory; Mentors; Methodology; Modeling; Nicotine Dependence; Nicotine Withdrawal; Obstructive Sleep Apnea; Patient Self-Report; Pattern; Periodicity; Phase; Play; Polysomnography; Population; Preparation; Prevention; Productivity; Protocols documentation; Questionnaires; Race; Reporting; Research; Research Personnel; Research Training; Rewards; Risk; Role; Sampling; Scientist; Series; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Smoke; Smoker; Smoking; Smoking Behavior; Smoking Prevention; Smoking Status; Symptoms; Testing; Time; Tobacco use; Training; Universities; Withdrawal; Withdrawal Symptom; actigraphy; addiction; base; career development; cigarette smoke; cigarette smoking; circadian; circadian regulation; clinical implementation; craving; design; disability; doctoral student; ethnic minority population; experience; handheld equipment; health disparity populations; irritation; minority disparity; neural circuit; non-smoker; novel; parent grant; parent project; perceived stress; poor sleep; pre-doctoral; programs; racial and ethnic; racial difference; racial disparity; racial diversity; racial identity; relapse prediction; respiratory; response; secondary analysis; skills; sleep quality; sleep quantity; sleep regulation; smoking addiction; smoking cessation; smoking intervention; smoking prevalence; socioeconomic disadvantage; substance use; temporal measurement; trend

Project Summary/Abstract The main objective behind this supplement application is to provide career development and research training to Ms. Sofía Mildrum Chana, B.A., doctoral student in the Medical/Clinical Psychology Program at the University of Alabama at Birmingham (UAB). This supplement, in response to PA-21-071 “Research Supplements to Promote Diversity in Health-Related Research (Admin Supp)”, will extend the parent project Circadian and Sleep Mechanisms among Racial Groups for Nicotine Dependence, Craving, And Withdrawal (R01 DA046096-01A1) led by Drs. Karen Cropsey and Karen Gamble (MPIs). This administrative supplement will support Ms. Mildrum Chana’s pre-doctoral education and career development activities, with the main goal being the advancement of her skills as an independent researcher in the field of substance use and sleep research. The primary aim of the present investigation is to evaluate the relationship between individuals’ smoking status and perceived stress in a sample of smokers and non-smokers. Specifically, a moderated mediation model is proposed whereby risk for obstructive sleep apnea (OSA) functions as a mediating variable in the association between smoking status and perceived stress. Additionally, individuals’ racial identity will be examined as a moderating variable in this model. The proposed study serves as an extension of the parent grant’s main goal of expanding current knowledge regarding the associations between cigarette smoking, sleep quality, and circadian rhythms in Blacks and Whites. The proposed study will further this investigation by specifically examining the impact of OSA in relation to individuals’ perceived stress and their smoking status. While the relationship between smoking and OSA is well established, research is needed to understand how smoking and OSA affect individuals’ perceived stress, and how additional variables, such as race/ethnicity, may further impact these relationships. Through a series of experiential and educational activities, Ms. Mildrum Chana’s training as a researcher will be enriched, contributing to her development as an independent scientist. The training and career development components of this administrative supplement will provide the necessary support for her advancement, in addition to the mentoring assistance provided by Ms. Mildrum Chana’s primary mentor, Dr. Karen Cropsey, and her secondary mentors Dr. Karen Gamble and Dr. S. Justin Thomas (Co-I in the parent grant). The combination of the training and learning opportunities provided by the present administrative supplement, along with the preparation from her Medical/Clinical Psychology doctoral program, will equip Ms. Mildrum Chana with the necessary abilities to be successful in her future research pursuits.

项目总结/文摘