Admin Core

行政核心项目摘要/摘要 管理核心的主要目标是集成、协调和管理组件 ZAMBAMA的所有组分（即，两个研究项目和两个额外的核心）。管理核心是 还负责所有预算（例如，处理支付、订购供应品）和监管活动（例如， 与NIAAA沟通，协调数据安全监查委员会活动，IRB活动，跟踪 不良事件），监测和管理总体进展，促进协调与合作 在项目内外的调查人员中。 管理核心的具体目标如下：1）实现科学目标，促进共享科学 项目之间的进度; 2）管理总体计划业务和法规要求;以及3） 加强项目内外调查人员之间的合作。通过本项目 格兰特，我们将利用我们的核心，研究项目和基础设施的基础设施，以实现我们的整体 旨在1）更好地描述精神疾病和物质使用共病的重叠负担， PLWH与不健康的酒精使用，2）评估是否以及如何合并症影响酒精减少 干预结果，3）确定跨诊断认知行为疗法的有效性，以及4） 审查与向弱势群体综合提供减少饮酒干预措施有关的执行因素 艾滋病毒感染者在一线艾滋病毒诊所。拟议的工作是一体化和协同增效的，行政核心职能是 利用该计划的基础设施、合作关系和多学科专业知识， 这些目标大于其各个部分的总和。

ADMINISTRATIVE CORE PROJECT SUMMARY/ABSTRACT The primary objective of the Administrative (Admin) Core is to integrate, coordinate, and manage components of all components of ZAMBAMA (i.e., the two research projects and two additional cores). The Admin core is also responsible for all budgetary (e.g., processing payments, ordering supplies) and regulatory activities (e.g., communication with NIAAA, coordination of Data Safety Monitoring Board activities, IRB activity, tracking adverse events), monitoring and managing overall progress, and promoting coordination and collaboration among investigators within and outside of the program. The Specific Aims of the Admin core are the following: 1) Synchronize scientific aims and foster shared scientific progress between the projects; 2) Manage overarching program business and regulatory requirements; and 3) Enhance collaboration among investigators within and outside of the program. Through this Program Project Grant, we will leverage the infrastructure of our cores, research projects, and infrastructure to achieve our overall aims to 1) better characterize the overlapping burden of mental illness and substance use comorbidity among PLWH with unhealthy alcohol use, 2) evaluate whether and how comorbidity impacts alcohol reduction intervention outcomes, 3) determine the effectiveness of a transdiagnostic cognitive behavioral therapy, and 4) examine implementation factors related to integrated delivery of alcohol reduction interventions to disadvantaged PLWH at front-line HIV clinics. The proposed work is integrated and synergistic, and the Admin Core function to leverage this program’s infrastructure, collaborative relationships, and multidisciplinary expertise to achieve goals that are greater than the sum of its individual parts.