Admin Core

管理核心

• 批准号: 10685454
• 负责人: Karen L Cropsey
• 金额: $ 10.25万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10685454
• 关键词: Acquired Immunodeficiency Syndrome; Adverse event; Advisory Committees; Alabama; Alcohol consumption; Alcohols; Amendment; Anxiety; Biological Markers; Businesses; Certification; Clinic; Clinical; Clinical Trials Data Monitoring Committees; Cognitive Therapy; Collaborations; Committee Members; Communication; Communities; Coordination and Collaboration; Data Analyses; Data Element; Development; Diagnostic; Disadvantaged; Disparity population; Elements; Emergency Situation; Ensure; Event; Faculty; Fostering; Funding; Gender; Goals; Grant; HIV; Incentives; Individual; Infectious Diseases Research; Infrastructure; Institution; Institutional Review Boards; International; Intervention; Lead; Manuscripts; Mental Health; Mental disorders; Mentors; Methods; Monitor; National Institute on Alcohol Abuse and Alcoholism; Outcome; Pain; Participant; Persons; Policies; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Preparation; Prevention; Program Research Project Grants; Progress Reports; Protocols documentation; Public Sector; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Services; Shipping; Sum; Symptoms; Training; Travel; United States National Institutes of Health; Universities; Work; Zambia; addiction; alcohol comorbidity; alcohol misuse; career; comorbidity; contextual factors; cost; data dissemination; data harmonization; depressive symptoms; effectiveness evaluation; effectiveness testing; human subject; implementation determinants; improved; meetings; multidisciplinary; neighborhood disadvantage; next generation; payment; pre-doctoral; programs; research study; substance use; symposium; treatment effect

ADMINISTRATIVE CORE PROJECT SUMMARY/ABSTRACT The primary objective of the Administrative (Admin) Core is to integrate, coordinate, and manage components of all components of ZAMBAMA (i.e., the two research projects and two additional cores). The Admin core is also responsible for all budgetary (e.g., processing payments, ordering supplies) and regulatory activities (e.g., communication with NIAAA, coordination of Data Safety Monitoring Board activities, IRB activity, tracking adverse events), monitoring and managing overall progress, and promoting coordination and collaboration among investigators within and outside of the program. The Specific Aims of the Admin core are the following: 1) Synchronize scientific aims and foster shared scientific progress between the projects; 2) Manage overarching program business and regulatory requirements; and 3) Enhance collaboration among investigators within and outside of the program. Through this Program Project Grant, we will leverage the infrastructure of our cores, research projects, and infrastructure to achieve our overall aims to 1) better characterize the overlapping burden of mental illness and substance use comorbidity among PLWH with unhealthy alcohol use, 2) evaluate whether and how comorbidity impacts alcohol reduction intervention outcomes, 3) determine the effectiveness of a transdiagnostic cognitive behavioral therapy, and 4) examine implementation factors related to integrated delivery of alcohol reduction interventions to disadvantaged PLWH at front-line HIV clinics. The proposed work is integrated and synergistic, and the Admin Core function to leverage this program’s infrastructure, collaborative relationships, and multidisciplinary expertise to achieve goals that are greater than the sum of its individual parts.

行政核心项目摘要/摘要 管理（管理）核心的主要目的是集成，协调和管理组件 在Zambama的所有组成部分中（即两个研究项目和两个其他核心）。管理员核心是 还负责所有预算（例如，处理付款，订购用品）和监管活动（例如， 与NIAAA沟通，数据安全监控委员会活动，IRB活动，跟踪 不利事件），监视和管理整体进度以及促进协调与协作 在计划内外的调查人员中。 管理员核心的具体目的是：1）同步科学目标并共享科学 项目之间的进展； 2）管理总体计划业务和监管要求； 3） 加强计划内外调查人员之间的协作。通过这个程序项目 格兰特，我们将利用核心，研究项目和基础设施的基础设施来实现我们的整体 目的是1）更好地表征精神疾病的重叠燃烧和使用合并症的物质的重叠 饮酒不健康的PLWH，2）评估合并症是否以及如何影响饮酒 干预结果，3）确定经诊断性认知行为疗法的有效性，4） 研究与综合提供饮酒干预措施相关的实施因素 前线HIV诊所的PLWH。拟议的工作是集成和协同作用的，管理员核心功能 利用该计划的基础架构，协作关系和多学科专业知识来实现 目标大于其各个部分的总和。