Circadian and sleep mechanisms among racial groups for nicotine dependence, craving, and withdrawal

不同种族群体对尼古丁依赖、渴望和戒断的昼夜节律和睡眠机制

• 批准号: 10612822
• 负责人: Karen L Cropsey
• 金额: $ 55.47万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612822
• 关键词: Acute; Adult; Affect; Alcohol consumption; Alcohols; Beds; Black Populations; Caring; Cause of Death; Cellular Phone; Characteristics; Cigarette; Circadian Dysregulation; Data; Development; Disparity; Drug usage; Ecological momentary assessment; Excessive Daytime Sleepiness; Exhibits; Goals; Heterogeneity; Hour; Intervention; Lead; Light; Link; Measures; Medical; Medical Care Costs; Melatonin; Memory; Methodology; Minority; Morbidity - disease rate; Nicotine Dependence; Nicotine Withdrawal; Obstructive Sleep Apnea; Patient Self-Report; Pattern; Periodicity; Phase; Polysomnography; Population; Population Heterogeneity; Prevention; Productivity; Protocols documentation; Questionnaires; Race; Reporting; Research; Rewards; Risk; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Smoke; Smoker; Smoking; Smoking Behavior; Smoking Prevention; Smoking Status; Smoking treatment; Symptoms; Testing; Time; Tobacco use; Withdrawal; Withdrawal Symptom; actigraphy; addiction; cigarette smoke; cigarette smoking; circadian; circadian regulation; cost estimate; craving; disability; ethnic minority; experience; handheld equipment; health disparity populations; minority disparity; mortality; neural circuit; non-smoker; novel; novel therapeutic intervention; poor sleep; programs; racial difference; racial disparity; racial diversity; racial minority; racial population; relapse prediction; secondary analysis; sleep quality; sleep quantity; sleep regulation; smoking abstinence; smoking addiction; smoking cessation; smoking intervention; smoking prevalence; socioeconomic disadvantage; temporal measurement; trend

PROJECT SUMMARY The number one preventable cause of death in the world is tobacco use. Cigarette smoking in particular, costs an estimated $300 billion due to expenses related to medical care and lost productivity. Despite similar smoking prevalence rates, Blacks suffer disproportionately from smoking-related harms compared to Whites. Sleep disparities such as shortened sleep duration, shorter circadian periodicity, earlier chronotype, and increased variability of sleep timing have been reported more frequently in Blacks compared to Whites. Given that poor sleep quality predicts relapse from smoking cessation programs, particularly among socioeconomically disadvantaged adults, sleep deficiencies and irregular timing of sleep may impact smoking craving and withdrawal symptoms over the course of the 24-hour day. Surprisingly, few studies have examined these temporal patterns of smoking and craving, and none with regard to sleep disruption, chronotype or racial disparities. A better understanding of these factors may explain heterogeneity within the smoking population, especially in minorities. Thus, the purpose of this proposal is to test the central hypothesis that the impact of chronotype and impaired sleep on cigarette usage as well as smoking dependence, urge/craving, and withdrawal depends on race. Three specific aims will determine: contributions of sleep timing and sleep quality and quantity to racial disparities in smoking status (Aim 1), objective sleep characteristics and smoking behavior among blacks and whites who smoke cigarettes (Aim 2), and whether sleep restriction modifies craving and withdrawal in racially diverse smokers (Aim 3). Specifically, we will utilize self-report questionnaires, objective measures of sleep quality and timing (actigraphy) and circadian phase (dim light melatonin onset), as well as ecological momentary assessment of cigarette use, smoking urges, cravings, and withdrawal symptoms to identify circadian and sleep characteristics that are most strongly associated with smoking status, heaviness of smoking and dependence among blacks and whites. Finally, we will test whether acute sleep restriction (4 hours of time-in- bed) versus sleep extension (10 hours of time-in-bed) modifies craving and withdrawal symptoms following cessation in black and white smokers. If successful, the results of this study will result in identification of circadian dysfunction and insufficient sleep as mechanisms that underlie the association between sleep and cigarette smoking behaviors and dependence in diverse populations. Moreover, these findings are likely to inform clinicians of the importance of sleep and sleep timing on cigarette smoking behaviors and dependence that will help in the development of novel interventions to reduce morbidity and mortality caused by tobacco use.

项目摘要 世界上可预防的死亡原因是烟草使用。特别是吸烟，费用 由于与医疗保健相关的费用和生产率降低，估计3000亿美元。尽管吸烟类似 与白人相比，黑人因吸烟有关的危害而遭受的危害不成比例。睡觉 差异缩短了睡眠持续时间，昼夜节期较短，更早的表型和增加 与白人相比，黑人的睡眠时间变化频率更高。鉴于那个穷人 睡眠质量可以预测戒烟计划的复发，尤其是在社会经济上 处境不利的成年人，睡眠不足和睡眠不规则时机可能会影响吸烟和 在24小时的时间内提取症状。令人惊讶的是，很少有研究检查这些 吸烟和渴望的时间模式，没有关于睡眠破坏，计时或种族的时间模式 差异。更好地了解这些因素可能解释了吸烟人群中的异质性， 特别是在少数民族中。因此，该提议的目的是检验中心假设，即 在香烟使用以及吸烟依赖，敦促/渴望和戒断的情况下睡觉和睡眠不足 取决于种族。三个具体目标将确定：睡眠时间和睡眠质量和数量的贡献 在吸烟状况中的种族差异（目标1），客观睡眠特征和吸烟行为 吸烟的黑人和白人（AIM 2），睡眠限制是否会改变渴望和戒断 在种族多样的吸烟者中（AIM 3）。具体而言，我们将利用自我报告问卷，客观衡量 睡眠质量和时机（艺术学）和昼夜节期（昏暗的褪黑激素发作）以及生态 瞬间评估香烟使用，吸烟，渴望和戒断症状以识别昼夜节律 和睡眠特征与吸烟状况，吸烟和吸烟的重度最密切相关 黑人和白人之间的依赖。最后，我们将测试是否急性睡眠限制（4小时的时间 床）与睡眠延长（10小时的床单）改变了渴望和戒断症状 黑白吸烟者停止。如果成功，这项研究的结果将导致昼夜节律识别 功能障碍和睡眠不足，作为睡眠与香烟之间关联的机制 吸烟行为和不同人群的依赖。而且，这些发现可能会告知 睡眠和睡眠时间对香烟吸烟行为和依赖的重要性的临床医生 有助于开发新的干预措施，以降低烟草使用引起的发病率和死亡率。

项目成果

Discrimination and insomnia: Examining depressive symptoms and nicotine withdrawal through a serial mediation model in a sample of smokers.

歧视和失眠：通过吸烟者样本的串行中介模型检查抑郁症状和尼古丁戒断。

• DOI: 10.1016/j.addbeh.2022.107506
• 发表时间: 2023
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: MildrumChana,Sofia;Palenski,PaigeE;Hawes,ElizabethS;Wolford-Clevenger,Caitlin;Thomas,SJustin;Gamble,KarenL;Cropsey,KarenL
• 通讯作者: Cropsey,KarenL