Circadian and sleep mechanisms among racial groups for nicotine dependence, craving, and withdrawal
不同种族群体对尼古丁依赖、渴望和戒断的昼夜节律和睡眠机制
基本信息
- 批准号:10612822
- 负责人:
- 金额:$ 55.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-15 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAdultAffectAlcohol consumptionAlcoholsBedsBlack PopulationsCaringCause of DeathCellular PhoneCharacteristicsCigaretteCircadian DysregulationDataDevelopmentDisparityDrug usageEcological momentary assessmentExcessive Daytime SleepinessExhibitsGoalsHeterogeneityHourInterventionLeadLightLinkMeasuresMedicalMedical Care CostsMelatoninMemoryMethodologyMinorityMorbidity - disease rateNicotine DependenceNicotine WithdrawalObstructive Sleep ApneaPatient Self-ReportPatternPeriodicityPhasePolysomnographyPopulationPopulation HeterogeneityPreventionProductivityProtocols documentationQuestionnairesRaceReportingResearchRewardsRiskSleepSleep Apnea SyndromesSleep DeprivationSleep DisordersSleep disturbancesSleeplessnessSmokeSmokerSmokingSmoking BehaviorSmoking PreventionSmoking StatusSmoking treatmentSymptomsTestingTimeTobacco useWithdrawalWithdrawal Symptomactigraphyaddictioncigarette smokecigarette smokingcircadiancircadian regulationcost estimatecravingdisabilityethnic minorityexperiencehandheld equipmenthealth disparity populationsminority disparitymortalityneural circuitnon-smokernovelnovel therapeutic interventionpoor sleepprogramsracial differenceracial disparityracial diversityracial minorityracial populationrelapse predictionsecondary analysissleep qualitysleep quantitysleep regulationsmoking abstinencesmoking addictionsmoking cessationsmoking interventionsmoking prevalencesocioeconomic disadvantagetemporal measurementtrend
项目摘要
PROJECT SUMMARY
The number one preventable cause of death in the world is tobacco use. Cigarette smoking in particular, costs
an estimated $300 billion due to expenses related to medical care and lost productivity. Despite similar smoking
prevalence rates, Blacks suffer disproportionately from smoking-related harms compared to Whites. Sleep
disparities such as shortened sleep duration, shorter circadian periodicity, earlier chronotype, and increased
variability of sleep timing have been reported more frequently in Blacks compared to Whites. Given that poor
sleep quality predicts relapse from smoking cessation programs, particularly among socioeconomically
disadvantaged adults, sleep deficiencies and irregular timing of sleep may impact smoking craving and
withdrawal symptoms over the course of the 24-hour day. Surprisingly, few studies have examined these
temporal patterns of smoking and craving, and none with regard to sleep disruption, chronotype or racial
disparities. A better understanding of these factors may explain heterogeneity within the smoking population,
especially in minorities. Thus, the purpose of this proposal is to test the central hypothesis that the impact of
chronotype and impaired sleep on cigarette usage as well as smoking dependence, urge/craving, and withdrawal
depends on race. Three specific aims will determine: contributions of sleep timing and sleep quality and quantity
to racial disparities in smoking status (Aim 1), objective sleep characteristics and smoking behavior among
blacks and whites who smoke cigarettes (Aim 2), and whether sleep restriction modifies craving and withdrawal
in racially diverse smokers (Aim 3). Specifically, we will utilize self-report questionnaires, objective measures of
sleep quality and timing (actigraphy) and circadian phase (dim light melatonin onset), as well as ecological
momentary assessment of cigarette use, smoking urges, cravings, and withdrawal symptoms to identify circadian
and sleep characteristics that are most strongly associated with smoking status, heaviness of smoking and
dependence among blacks and whites. Finally, we will test whether acute sleep restriction (4 hours of time-in-
bed) versus sleep extension (10 hours of time-in-bed) modifies craving and withdrawal symptoms following
cessation in black and white smokers. If successful, the results of this study will result in identification of circadian
dysfunction and insufficient sleep as mechanisms that underlie the association between sleep and cigarette
smoking behaviors and dependence in diverse populations. Moreover, these findings are likely to inform
clinicians of the importance of sleep and sleep timing on cigarette smoking behaviors and dependence that will
help in the development of novel interventions to reduce morbidity and mortality caused by tobacco use.
项目摘要
世界上第一大可预防的死亡原因是烟草使用。尤其是吸烟,
估计有3000亿美元是由于医疗保健和生产力损失造成的。尽管类似的吸烟
尽管吸烟的患病率很高,但与白人相比,黑人遭受的吸烟相关危害不成比例。睡眠
差异,如缩短睡眠时间,缩短昼夜节律周期,更早的时钟型,并增加
据报道,与白人相比,黑人的睡眠时间变化更频繁。鉴于穷人
睡眠质量预测戒烟计划的复发,特别是在社会经济方面
弱势成年人,睡眠不足和不规律的睡眠时间可能会影响吸烟的渴望,
戒断症状在一天的24小时内。令人惊讶的是,很少有研究调查这些
吸烟和渴望的时间模式,而没有关于睡眠中断,时钟类型或种族
差距。更好地理解这些因素可以解释吸烟人群中的异质性,
尤其是少数民族。因此,本提案的目的是检验中心假设,即
吸烟、吸烟依赖、冲动/渴望和戒断与睡眠障碍的关系
取决于种族。三个具体目标将决定:睡眠时间和睡眠质量和数量的贡献
吸烟状况(目标1)、客观睡眠特征和吸烟行为的种族差异
吸烟的黑人和白人(目标2),以及睡眠限制是否会改变烟瘾和戒断症状
不同种族的吸烟者(目标3)。具体来说,我们将利用自我报告问卷,客观的措施,
睡眠质量和时间(活动记录)和昼夜节律阶段(暗光褪黑激素开始),以及生态
瞬时评估香烟使用、吸烟欲望、渴望和戒断症状,以确定昼夜节律
睡眠特征与吸烟状况、吸烟严重程度和
黑人和白人之间的依赖。最后,我们将测试是否急性睡眠限制(4小时的时间,
床)与睡眠延长(10小时的床上时间)相比,
黑人和白色吸烟者戒烟。如果成功,这项研究的结果将导致识别昼夜节律
功能障碍和睡眠不足是睡眠和吸烟之间联系的基础机制
不同人群的吸烟行为和依赖性。此外,这些发现可能会提供信息,
睡眠和睡眠时间对吸烟行为和依赖性的重要性,
帮助制定新的干预措施,以减少烟草使用造成的发病率和死亡率。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Discrimination and insomnia: Examining depressive symptoms and nicotine withdrawal through a serial mediation model in a sample of smokers.
歧视和失眠:通过吸烟者样本的串行中介模型检查抑郁症状和尼古丁戒断。
- DOI:10.1016/j.addbeh.2022.107506
- 发表时间:2023
- 期刊:
- 影响因子:4.4
- 作者:MildrumChana,Sofia;Palenski,PaigeE;Hawes,ElizabethS;Wolford-Clevenger,Caitlin;Thomas,SJustin;Gamble,KarenL;Cropsey,KarenL
- 通讯作者:Cropsey,KarenL
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Karen L Cropsey其他文献
Predictors of MOUD referral among persons with involvement in the criminal legal system.
MOUD 向涉及刑事法律系统的人员转介的预测因素。
- DOI:
10.5055/jom.0831 - 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Andrew P. Bontemps;Sofía Mildrum Chana;Elizabeth S Hawes;Yoser Al Rawi;Christina E Cenczyk;Lindsey R Atkins;Li Li;Karen L Cropsey - 通讯作者:
Karen L Cropsey
Karen L Cropsey的其他文献
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{{ truncateString('Karen L Cropsey', 18)}}的其他基金
Medications for opioid use disorder differentially modulate intrinsically photosensitive retinal ganglion cell function, sleep, and circadian rhythms: implications for treatment
治疗阿片类药物使用障碍的药物差异调节本质光敏性视网膜神经节细胞功能、睡眠和昼夜节律:对治疗的影响
- 批准号:
10783274 - 财政年份:2023
- 资助金额:
$ 55.47万 - 项目类别:
Zambia Alabama HIV Alcohol Comorbidities Program (ZAMBAMA)
赞比亚阿拉巴马州艾滋病毒酒精合并症计划 (ZAMBAMA)
- 批准号:
10685452 - 财政年份:2021
- 资助金额:
$ 55.47万 - 项目类别:
Zambia Alabama HIV Alcohol Comorbidities Program (ZAMBAMA)
赞比亚阿拉巴马州艾滋病毒酒精合并症计划 (ZAMBAMA)
- 批准号:
10303936 - 财政年份:2021
- 资助金额:
$ 55.47万 - 项目类别:
Circadian and sleep mechanisms among racial groups for nicotine dependence, craving, and withdrawal
不同种族群体对尼古丁依赖、渴望和戒断的昼夜节律和睡眠机制
- 批准号:
10206083 - 财政年份:2020
- 资助金额:
$ 55.47万 - 项目类别:
Circadian and sleep mechanisms among racial groups for nicotine dependence, craving, and withdrawal
不同种族群体对尼古丁依赖、渴望和戒断的昼夜节律和睡眠机制
- 批准号:
10393609 - 财政年份:2020
- 资助金额:
$ 55.47万 - 项目类别:
Circadian and sleep mechanisms among racial groups for nicotine dependence, craving, and withdrawal
不同种族群体对尼古丁依赖、渴望和戒断的昼夜节律和睡眠机制
- 批准号:
9976302 - 财政年份:2020
- 资助金额:
$ 55.47万 - 项目类别:
Circadian and sleep mechanisms among racial groups for nicotine dependence, craving, and withdrawal
不同种族群体对尼古丁依赖、渴望和戒断的昼夜节律和睡眠机制
- 批准号:
10351944 - 财政年份:2020
- 资助金额:
$ 55.47万 - 项目类别:
In Vivo Experience with NRT to Increase Adherence and Smoking Abstinence
使用 NRT 提高依从性和戒烟率的体内经验
- 批准号:
9324175 - 财政年份:2016
- 资助金额:
$ 55.47万 - 项目类别:
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