Center for Musculoskeletal Disease Research (CMDR)

肌肉骨骼疾病研究中心 (CMDR)

• 批准号: 10495741
• 负责人: CHARLES A O'BRIEN
• 金额: $ 229.5万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-16 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10495741
• 关键词: Achievement; Affect; Animals; Arkansas; Benchmarking; Bioinformatics; Biomedical Research; CRISPR interference; Centers of Research Excellence; Clinical Investigator; Collaborations; Degenerative polyarthritis; Development; Disease; Environment; Faculty; Fertilization in Vitro; Functional disorder; Funding; Gene Expression Profiling; Genetic Models; Goals; Grant; Health; Health Care Costs; Histology; Image; Institution; Lead; Malignant Neoplasms; Measures; Medical; Mentors; Molecular; Molecular Analysis; Multiple Myeloma; Mus; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; National Institute of General Medical Sciences; Osteomyelitis; Osteoporosis; Patients; Phase; Pilot Projects; Play; Population; Productivity; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Sampling; Science; Scientist; Services; Skeleton; Structure; Technology; Universities; bone; bone imaging; disability; effective therapy; experience; genetic manipulation; in vivo; innovative technologies; loss of function; malignant breast neoplasm; mouse model; negative affect; novel; novel strategies; programs; recruit; skeletal abnormality; sperm cryopreservation; success; synergism; web-based tool

PROJECT SUMMARY/ABSTRACT - OVERALL Conditions such as osteoporosis and osteoarthritis, and malignancies such as breast cancer, negatively affect the musculoskeletal system, leading to substantial disability and health care costs. Thus, there is an ongoing need to better understand the causes of these conditions and to support development of more effective and well-tolerated therapies. The Center for Musculoskeletal Disease Research (CMDR) was established at the University of Arkansas for Medical Sciences (UAMS) during Phase 1 to meet this need. The scientific theme of the CMDR is that identification of molecular contributors to musculoskeletal dysfunction and disease will guide development of effective therapies. To study these conditions, we have assembled teams of junior and established investigators and supported development of junior investigators to the point of achieving independent R01-level funding. We also utilize state-of-the-art technologies to analyze gene expression, genetically manipulate animals, and analyze the skeleton. These complementary approaches, together with access to clinical investigators and patient samples, have synergized to create a unique and productive research environment. A key to the continued success of the Center will be to increase the number of investigators whose research is aligned with our scientific theme via development of more junior investigators and recruitment of new and established investigators. To accomplish this, in Phase 2 we propose to support the development of 3 Project Leaders by providing structured mentoring, financial resources, and collaboration with other CMDR investigators (Aim 1). We will also continue to strengthen the biomedical research infrastructure at UAMS by increasing the capabilities and utilization of 4 research cores that provide access to rapid, high-quality services and that develop new approaches, such as CRISPR interference for in vivo loss-of-function studies (Aim 2). To continue building a critical mass of musculoskeletal investigators and teams, the Center will utilize a Pilot Project Program, targeted recruitment of investigators with complementary expertise, and incorporation of new and established center investigators into synergistic and productive research teams (Aim 3). Successful implementation of this Organization and Management Plan will, in the long-term, lead to a self-sustaining Center of Biomedical Research Excellence that will generate novel and important results leading to more effective therapies for the numerous conditions that involve the musculoskeletal system.

项目总结/摘要-总体 骨质疏松症和骨关节炎等疾病以及乳腺癌等恶性肿瘤， 影响肌肉骨骼系统，导致严重残疾和医疗保健费用。因此， 持续需要更好地了解这些情况的原因，并支持发展更有效的 和耐受性良好的治疗。肌肉骨骼疾病研究中心（CMDR）成立于 阿肯色州医学科学大学（UAMS）在第1阶段，以满足这一需求。的科学主题 CMDR是对肌肉骨骼功能障碍和疾病分子贡献者的鉴定， 开发有效的治疗方法。为了研究这些情况，我们召集了初级和 设立调查员，并支持初级调查员的发展，以实现独立调查 R 01级融资。我们还利用最先进的技术来分析基因表达， 操纵动物，分析骨骼这些补充办法，加上获得 临床研究人员和患者样本，协同创造了一个独特的和富有成效的研究 环境该中心继续取得成功的一个关键是增加调查人员的数量， 通过发展更多的初级研究人员和招募新的研究人员， 和既定的调查员。为达致这个目标，我们建议在第二阶段支援发展3项计划， 通过提供结构化的指导、财务资源以及与其他CMDR调查人员的协作， (Aim 1）。我们还将继续加强UAMS的生物医学研究基础设施， 4个研究核心的能力和利用率，提供快速，高质量的服务，并开发 新方法，如用于体内功能丧失研究的CRISPR干扰（目标2）。继续建设 肌肉骨骼研究人员和团队的临界质量，该中心将利用试点项目计划，有针对性地 招募具有互补专业知识的研究者，并合并新的和已建立的中心 将研究人员转化为具有协同作用和富有成效的研究团队（目标3）。成功实施这一 从长远来看，组织和管理计划将导致生物医学中心的自我维持 卓越的研究，将产生新的和重要的结果，导致更有效的治疗方法， 许多涉及肌肉骨骼系统的疾病。