Administrative Core

项目摘要/摘要--核心A Cobre Support的第一阶段建立了肌肉骨骼疾病研究中心(CMDR) 阿肯色州医科大学(UAMS)。CMDR的科学主题是确定 肌肉骨骼功能障碍和疾病的分子贡献者将指导有效治疗的开发。 该中心在第一阶段取得了关键里程碑，包括指导和支持初级调查人员 按照获得R01级资金的定义，实现独立的点。这些努力与 招募成熟的研究人员，大大增加了成功进行肌肉骨骼手术的数量 我们中心的调查人员。在第一阶段建立的三个Cmdr研究核心也有助于 我们初级调查人员和其他中心成员的成功，大大加强了生物医学 我们机构的研究基础设施。协调发展委员会有效运作的一个重要组成部分是 建立管理核心(核心A)，负责管理基础设施、监督和日常工作 该中心的运作。在第二阶段，行政核心将继续监督所有组织和 在内部和外部咨询委员会的支持下，协调发展委员会的预算问题(目标1)。此外, 核心将通过指导和结构化的教师发展计划来支持CMDR的发展，该计划将支持 项目负责人指出R01级别的资金(目标2)。行政核心还将招聘和促进 通过试点项目方案开发新的调查员，有针对性地招聘新的调查员，以及 咨询委员会对中心进展情况的评价(目标3)。这些目标将在 中心主任和副主任的领导，在经验丰富的导师和 咨询委员会，将使专注于肌肉骨骼研究的项目负责人能够有效地竞争 用于R01级别的资金。行政核心还将监督四个研究核心的运作，这些核心提供 最先进的服务，以创建新的遗传模型(核心B)，执行专门的骨骼组织学和库 人骨组织(核心C)，提供骨成像和量化(核心D)，并执行生物信息学 大分子数据集分析(CORE E)。这一战略的总体成功将通过实现以下指标来衡量 第二阶段支持五年内的以下里程碑：1)三名或更多项目负责人将获得 R01级研究资助；2)将选出三名或更多新的项目负责人并加入中心；3) 项目负责人和中心其他成员将出版25至50份同行评议的出版物；以及4) 毕业的项目负责人和中心的其他成员将开展富有成效的合作并提交 中央级拨款申请，如P01或P30。

PROJECT SUMMARY/ABSTRACT – CORE A Phase 1 of COBRE support established the Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS). The scientific theme of the CMDR is that identification of molecular contributors to musculoskeletal dysfunction and disease will guide development of effective therapies. The Center achieved key milestones during Phase 1, including mentoring and support of junior investigators to the point of achieving independence, as defined by obtaining R01-level funding. These efforts, combined with recruitment of established investigators, have significantly expanded the number of successful musculoskeletal investigators in our Center. The three CMDR research cores established during Phase 1 also contributed to the success of our junior investigators and other center members and significantly strengthened the biomedical research infrastructure of our institution. An essential component of the effective operation of the CMDR was establishment of the Administrative Core (Core A), which manages the infrastructure, oversight, and day-to-day functioning of the Center. During Phase 2, the Administrative Core will continue to oversee all organizational and budgetary aspects of the CMDR, supported by internal and external advisory committees (Aim 1). In addition, the core will support CMDR growth via mentoring and a structured faculty development plan that will support Project Leaders to point of R01-level funding (Aim 2). The Administrative Core will also recruit and promote the development of new investigators via a Pilot Project Program, targeted recruitment of new investigators, and evaluation of Center progress by the advisory committees (Aim 3). These goals will be accomplished under the leadership of the Center Director and Associate Director who, with the support of experienced mentors and advisory committees, will enable Project Leaders focused on musculoskeletal research to compete effectively for R01-level funding. The Administrative Core will also oversee the operation of four Research Cores providing state-of-the-art services to create new genetic models (Core B), perform specialized skeletal histology and bank human bone tissue (Core C), provide bone imaging and quantification (Core D), and perform bioinformatic analyses of large molecular datasets (Core E). The overall success of this strategy will be gauged by achieving the following milestones within the five years of Phase 2 support: 1) three or more Project Leaders will obtain R01-level research grant support; 2) three or more new Project Leaders will be selected and join the Center; 3) Project Leaders and other Center members will publish between 25 and 50 peer-reviewed publications; and 4) graduated Project Leaders and other members of the Center will develop productive collaborations and submit a center-level grant application, such as a P01 or P30.