Administrative Core

项目概要/摘要-核心A COBRE支持的第一阶段在纽约建立了肌肉骨骼疾病研究中心（CMDR）。 阿肯色州医学科学大学。CMDR的科学主题是识别 肌肉骨骼功能障碍和疾病的分子贡献者将指导有效疗法的开发。 该中心在第1阶段实现了关键里程碑，包括指导和支持初级研究人员， 获得R 01级资金所定义的实现独立的点。这些努力，加上 招募既定的研究人员，大大增加了成功的肌肉骨骼 我们中心的调查员。在第一阶段建立的三个CMDR研究核心也有助于 我们的初级研究人员和其他中心成员的成功，大大加强了生物医学 我们机构的研究基础设施。CMDR有效运行的一个重要组成部分是 建立行政核心（核心A），负责管理基础设施、监督和日常事务。 中心的运作。在第二阶段，行政核心将继续监督所有组织和 CMDR的预算方面，由内部和外部咨询委员会提供支持（目标1）。此外，本发明还提供了一种方法， 核心将通过指导和结构化的教师发展计划来支持CMDR的发展， 项目领导人到R 01级供资点（目标2）。行政核心还将招募和促进 通过试点项目计划培养新研究者，有针对性地招募新研究者，以及 由咨询委员会对中心的进展情况进行评估（目标3）。这些目标将在 中心主任和副主任的领导，在经验丰富的导师的支持下， 咨询委员会，将使项目领导人专注于肌肉骨骼研究，以有效地竞争 R 01级融资。行政核心还将监督四个研究核心的运作， 最先进的服务，以创建新的遗传模型（核心B），进行专门的骨骼组织学和银行 人骨组织（核心C），提供骨成像和定量（核心D），并进行生物信息学 大型分子数据集的分析（核心E）。这一战略的总体成功将通过实现 在第二阶段支持的五年内实现以下里程碑：1）三个或更多项目负责人将获得 R 01级科研经费支持; 2）3名以上新项目负责人将被选拔加入中心; 3） 项目负责人和其他中心成员将发表25至50篇同行评审的出版物;以及4） 毕业的项目负责人和中心的其他成员将发展富有成效的合作，并提交 中心级补助申请，如P01或P30。

PROJECT SUMMARY/ABSTRACT – CORE A Phase 1 of COBRE support established the Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS). The scientific theme of the CMDR is that identification of molecular contributors to musculoskeletal dysfunction and disease will guide development of effective therapies. The Center achieved key milestones during Phase 1, including mentoring and support of junior investigators to the point of achieving independence, as defined by obtaining R01-level funding. These efforts, combined with recruitment of established investigators, have significantly expanded the number of successful musculoskeletal investigators in our Center. The three CMDR research cores established during Phase 1 also contributed to the success of our junior investigators and other center members and significantly strengthened the biomedical research infrastructure of our institution. An essential component of the effective operation of the CMDR was establishment of the Administrative Core (Core A), which manages the infrastructure, oversight, and day-to-day functioning of the Center. During Phase 2, the Administrative Core will continue to oversee all organizational and budgetary aspects of the CMDR, supported by internal and external advisory committees (Aim 1). In addition, the core will support CMDR growth via mentoring and a structured faculty development plan that will support Project Leaders to point of R01-level funding (Aim 2). The Administrative Core will also recruit and promote the development of new investigators via a Pilot Project Program, targeted recruitment of new investigators, and evaluation of Center progress by the advisory committees (Aim 3). These goals will be accomplished under the leadership of the Center Director and Associate Director who, with the support of experienced mentors and advisory committees, will enable Project Leaders focused on musculoskeletal research to compete effectively for R01-level funding. The Administrative Core will also oversee the operation of four Research Cores providing state-of-the-art services to create new genetic models (Core B), perform specialized skeletal histology and bank human bone tissue (Core C), provide bone imaging and quantification (Core D), and perform bioinformatic analyses of large molecular datasets (Core E). The overall success of this strategy will be gauged by achieving the following milestones within the five years of Phase 2 support: 1) three or more Project Leaders will obtain R01-level research grant support; 2) three or more new Project Leaders will be selected and join the Center; 3) Project Leaders and other Center members will publish between 25 and 50 peer-reviewed publications; and 4) graduated Project Leaders and other members of the Center will develop productive collaborations and submit a center-level grant application, such as a P01 or P30.