Center for Musculoskeletal Disease Research (CMDR)

肌肉骨骼疾病研究中心 (CMDR)

基本信息

  • 批准号:
    10117257
  • 负责人:
  • 金额:
    $ 227.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-02-16 至 2023-01-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Conditions such as osteoporosis, osteoarthritis, developmental abnormalities of the skeleton, as well as malignancies, such as multiple myeloma and breast cancer metastases, all negatively affect the musculoskeletal system. These conditions affect the health of a sizable percentage of the US population and lead to significant disability and substantial health care costs, and there is an ongoing need to better understand their causes and to support the development of more effective and well-tolerated therapies. To address this need, we propose to establish and develop a thematic and multidisciplinary Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS). The scientific theme of the CMDR is that molecular and genetic analysis of musculoskeletal diseases, and conditions that involve the skeleton as part of their disease process, will lead to a better understanding of their causes and will support development of novel therapies. Our approach to studying these conditions will take advantage of state-of-the-art approaches to analyze the genome and transcriptome, the genetic manipulation of cells and animals, and skeletal phenotyping. A key to the success of this approach will be to increase the number of investigators whose research is aligned with the scientific theme of the Center via development of junior investigators and recruitment of new and established investigators. We will establish the CMDR on a strong foundation of musculoskeletal research and implement an Organization and Management Plan to create a self-sustaining Center of Biomedical Research Excellence (Aim 1). We will also provide multidisciplinary development and unique research opportunities to young investigators and support them to the point of independence (Aim 2). Lastly, we will create diverse teams of productive investigators by providing access to effective and useful research cores that produce significant and long-lasting benefits to the research infrastructure of UAMS and its affiliated institutions (Aim 3). The Overall Center Organization and Management Plan includes the Administrative Core, three research cores, and four research projects, led by promising junior investigators. The Administrative Core will oversee establishment and operation of the center, the three research cores, and a faculty development plan. The integrated and interactive faculty development plan will include a formal mentoring program that will guide four junior investigators to independence. The CMDR research cores include a Genetic Models Core that will use cutting-edge approaches to genetically manipulate cells and mice, a Bone Histology and Imaging Core that will analyze mouse and human hard tissues, and a Bioinformatics Core that will analyze the large datasets generated by the molecular analyses of cells from mouse and human samples. Successful implementation of this Organization and Management Plan will in the long-term lead to a self-sustaining Center of Biomedical Research Excellence that will generate novel and important results leading to more effective therapies for a variety of conditions that involve the musculoskeletal system.
项目总结/摘要 诸如骨质疏松症、骨关节炎、骨骼发育异常以及 恶性肿瘤,如多发性骨髓瘤和乳腺癌转移,都对肌肉骨骼产生负面影响。 系统这些条件影响了相当大比例的美国人口的健康,并导致严重的疾病。 残疾和大量的医疗保健费用,并不断需要更好地了解其原因, 以支持开发更有效和耐受性更好的治疗方法。为了满足这一需求,我们建议 建立和发展一个专题和多学科的肌肉骨骼疾病研究中心(CMDR) 在阿肯色州大学医学科学(UAMS)。CMDR的科学主题是, 和肌肉骨骼疾病的遗传分析,以及涉及骨骼作为其疾病的一部分的条件 这一过程,将导致更好地了解其原因,并将支持新疗法的发展。我们 研究这些疾病的方法将利用最先进的方法来分析基因组 和转录组,细胞和动物的遗传操作,以及骨骼表型。成功的关键 这种方法的一个重要方面是增加研究人员的数量, 通过发展初级研究者和招聘新的和已建立的研究者来实现中心的主题。 我们将在肌肉骨骼研究的坚实基础上建立CMDR, 和管理计划,以创建一个自我维持的生物医学研究卓越中心(目标1)。我们将 还提供多学科的发展和独特的研究机会,以年轻的研究人员和支持 2、独立性(Aim 2)。最后,我们将通过以下方式创建多样化的高效调查人员团队: 提供获得有效和有用的研究核心,产生重大和持久的利益, UAMS及其附属机构的研究基础设施(目标3)。整个中心组织和 管理计划包括行政核心、三个研究核心和四个研究项目,由 有前途的初级调查员行政核心将监督中心的建立和运作, 三个研究核心和一个教师发展计划。综合互动式教师发展 该计划将包括一个正式的指导计划,将指导四名初级调查员独立工作。CMDR 研究核心包括一个遗传模型核心,它将使用尖端的方法来遗传操纵 细胞和小鼠,骨组织学和成像核心,将分析小鼠和人类硬组织, 生物信息学核心,将分析由小鼠细胞分子分析生成的大型数据集 和人体样本本组织和管理计划的成功实施将从长远角度 导致一个自我维持的生物医学研究卓越中心,将产生新的和重要的成果 从而导致对涉及肌肉骨骼系统的各种病症的更有效的治疗。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

CHARLES A O'BRIEN其他文献

CHARLES A O'BRIEN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('CHARLES A O'BRIEN', 18)}}的其他基金

Genetic Models
遗传模型
  • 批准号:
    10357774
  • 财政年份:
    2018
  • 资助金额:
    $ 227.44万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10117260
  • 财政年份:
    2018
  • 资助金额:
    $ 227.44万
  • 项目类别:
Center for Musculoskeletal Disease Research (CMDR)
肌肉骨骼疾病研究中心 (CMDR)
  • 批准号:
    10357772
  • 财政年份:
    2018
  • 资助金额:
    $ 227.44万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10357773
  • 财政年份:
    2018
  • 资助金额:
    $ 227.44万
  • 项目类别:
Genetic Models
遗传模型
  • 批准号:
    10117261
  • 财政年份:
    2018
  • 资助金额:
    $ 227.44万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10495742
  • 财政年份:
    2018
  • 资助金额:
    $ 227.44万
  • 项目类别:
Center for Musculoskeletal Disease Research (CMDR)
肌肉骨骼疾病研究中心 (CMDR)
  • 批准号:
    10495741
  • 财政年份:
    2018
  • 资助金额:
    $ 227.44万
  • 项目类别:
RANKL and lymphocyte-mediated bone loss
RANKL 和淋巴细胞介导的骨丢失
  • 批准号:
    9275307
  • 财政年份:
    2009
  • 资助金额:
    $ 227.44万
  • 项目类别:
RANKL and lymphocyte-mediated bone loss
RANKL 和淋巴细胞介导的骨丢失
  • 批准号:
    8633709
  • 财政年份:
    2009
  • 资助金额:
    $ 227.44万
  • 项目类别:
RANKL and Inflammation-associated Bone Loss
RANKL 和炎症相关的骨丢失
  • 批准号:
    8258635
  • 财政年份:
    2009
  • 资助金额:
    $ 227.44万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 227.44万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 227.44万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 227.44万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 227.44万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 227.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 227.44万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 227.44万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 227.44万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 227.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 227.44万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了