Center for Musculoskeletal Disease Research (CMDR)

肌肉骨骼疾病研究中心 (CMDR)

• 批准号: 10117257
• 负责人: CHARLES A O'BRIEN
• 金额: $ 227.44万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-16 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10117257
• 关键词: Address; Affect; Animals; Arkansas; Bioinformatics; Bone remodeling; Breast cancer metastasis; Cells; Centers of Research Excellence; Clinical; Clinical Investigator; Degenerative polyarthritis; Development; Development Plans; Disease; Doctor of Philosophy; Environment; Faculty; Foundations; Funding; Genetic Models; Genome; Goals; Grant; Health; Health Care Costs; Histology; Human; Image; Institutes; Institution; International; Lead; Malignant Neoplasms; Medical; Medicine; Mentors; Methods; Molecular Analysis; Multiple Myeloma; Mus; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Orthopedics; Osteomyelitis; Osteoporosis; Pathologic; Patients; Phenotype; Pilot Projects; Population; Process; Research; Research Infrastructure; Research Personnel; Research Project Grants; Sampling; Science; Scientist; Skeleton; Teacher Professional Development; Tissues; United States National Institutes of Health; Universities; Work; bone; disability; effective therapy; experience; genetic analysis; genetic manipulation; large datasets; malignant breast neoplasm; mouse genetics; multidisciplinary; negative affect; novel; novel therapeutics; operation; professor; programs; recruit; skeletal; success; transcriptome

PROJECT SUMMARY/ABSTRACT Conditions such as osteoporosis, osteoarthritis, developmental abnormalities of the skeleton, as well as malignancies, such as multiple myeloma and breast cancer metastases, all negatively affect the musculoskeletal system. These conditions affect the health of a sizable percentage of the US population and lead to significant disability and substantial health care costs, and there is an ongoing need to better understand their causes and to support the development of more effective and well-tolerated therapies. To address this need, we propose to establish and develop a thematic and multidisciplinary Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS). The scientific theme of the CMDR is that molecular and genetic analysis of musculoskeletal diseases, and conditions that involve the skeleton as part of their disease process, will lead to a better understanding of their causes and will support development of novel therapies. Our approach to studying these conditions will take advantage of state-of-the-art approaches to analyze the genome and transcriptome, the genetic manipulation of cells and animals, and skeletal phenotyping. A key to the success of this approach will be to increase the number of investigators whose research is aligned with the scientific theme of the Center via development of junior investigators and recruitment of new and established investigators. We will establish the CMDR on a strong foundation of musculoskeletal research and implement an Organization and Management Plan to create a self-sustaining Center of Biomedical Research Excellence (Aim 1). We will also provide multidisciplinary development and unique research opportunities to young investigators and support them to the point of independence (Aim 2). Lastly, we will create diverse teams of productive investigators by providing access to effective and useful research cores that produce significant and long-lasting benefits to the research infrastructure of UAMS and its affiliated institutions (Aim 3). The Overall Center Organization and Management Plan includes the Administrative Core, three research cores, and four research projects, led by promising junior investigators. The Administrative Core will oversee establishment and operation of the center, the three research cores, and a faculty development plan. The integrated and interactive faculty development plan will include a formal mentoring program that will guide four junior investigators to independence. The CMDR research cores include a Genetic Models Core that will use cutting-edge approaches to genetically manipulate cells and mice, a Bone Histology and Imaging Core that will analyze mouse and human hard tissues, and a Bioinformatics Core that will analyze the large datasets generated by the molecular analyses of cells from mouse and human samples. Successful implementation of this Organization and Management Plan will in the long-term lead to a self-sustaining Center of Biomedical Research Excellence that will generate novel and important results leading to more effective therapies for a variety of conditions that involve the musculoskeletal system.

项目总结/摘要 诸如骨质疏松症、骨关节炎、骨骼发育异常以及 恶性肿瘤，如多发性骨髓瘤和乳腺癌转移，都对肌肉骨骼产生负面影响。 系统这些条件影响了相当大比例的美国人口的健康，并导致严重的疾病。 残疾和大量的医疗保健费用，并不断需要更好地了解其原因， 以支持开发更有效和耐受性更好的治疗方法。为了满足这一需求，我们建议 建立和发展一个专题和多学科的肌肉骨骼疾病研究中心（CMDR） 在阿肯色州大学医学科学（UAMS）。CMDR的科学主题是， 和肌肉骨骼疾病的遗传分析，以及涉及骨骼作为其疾病的一部分的条件 这一过程，将导致更好地了解其原因，并将支持新疗法的发展。我们 研究这些疾病的方法将利用最先进的方法来分析基因组 和转录组，细胞和动物的遗传操作，以及骨骼表型。成功的关键 这种方法的一个重要方面是增加研究人员的数量， 通过发展初级研究者和招聘新的和已建立的研究者来实现中心的主题。 我们将在肌肉骨骼研究的坚实基础上建立CMDR， 和管理计划，以创建一个自我维持的生物医学研究卓越中心（目标1）。我们将 还提供多学科的发展和独特的研究机会，以年轻的研究人员和支持 2、独立性（Aim 2）。最后，我们将通过以下方式创建多样化的高效调查人员团队： 提供获得有效和有用的研究核心，产生重大和持久的利益， UAMS及其附属机构的研究基础设施（目标3）。整个中心组织和 管理计划包括行政核心、三个研究核心和四个研究项目，由 有前途的初级调查员行政核心将监督中心的建立和运作， 三个研究核心和一个教师发展计划。综合互动式教师发展 该计划将包括一个正式的指导计划，将指导四名初级调查员独立工作。CMDR 研究核心包括一个遗传模型核心，它将使用尖端的方法来遗传操纵 细胞和小鼠，骨组织学和成像核心，将分析小鼠和人类硬组织， 生物信息学核心，将分析由小鼠细胞分子分析生成的大型数据集 和人体样本本组织和管理计划的成功实施将从长远角度 导致一个自我维持的生物医学研究卓越中心，将产生新的和重要的成果 从而导致对涉及肌肉骨骼系统的各种病症的更有效的治疗。