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Center for Musculoskeletal Disease Research (CMDR)

肌肉骨骼疾病研究中心 (CMDR)

基本信息

批准号：
10117257
负责人：
CHARLES A O'BRIEN
金额：
$ 227.44万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-16 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10117257
关键词：
Address Affect Animals Arkansas Bioinformatics Bone remodeling Breast cancer metastasis Cells Centers of Research Excellence Clinical Clinical Investigator Degenerative polyarthritis Development Development Plans Disease Doctor of Philosophy Environment Faculty Foundations Funding Genetic Models Genome Goals Grant Health Health Care Costs Histology Human Image Institutes Institution International Lead Malignant Neoplasms Medical Medicine Mentors Methods Molecular Analysis Multiple Myeloma Mus Musculoskeletal Musculoskeletal Diseases Musculoskeletal System Orthopedics Osteomyelitis Osteoporosis Pathologic Patients Phenotype Pilot Projects Population Process Research Research Infrastructure Research Personnel Research Project Grants Sampling Science Scientist Skeleton Teacher Professional Development Tissues United States National Institutes of Health Universities Work bone disability effective therapy experience genetic analysis genetic manipulation large datasets malignant breast neoplasm mouse genetics multidisciplinary negative affect novel novel therapeutics operation professor programs recruit skeletal success transcriptome

项目摘要

PROJECT SUMMARY/ABSTRACT Conditions such as osteoporosis, osteoarthritis, developmental abnormalities of the skeleton, as well as malignancies, such as multiple myeloma and breast cancer metastases, all negatively affect the musculoskeletal system. These conditions affect the health of a sizable percentage of the US population and lead to significant disability and substantial health care costs, and there is an ongoing need to better understand their causes and to support the development of more effective and well-tolerated therapies. To address this need, we propose to establish and develop a thematic and multidisciplinary Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS). The scientific theme of the CMDR is that molecular and genetic analysis of musculoskeletal diseases, and conditions that involve the skeleton as part of their disease process, will lead to a better understanding of their causes and will support development of novel therapies. Our approach to studying these conditions will take advantage of state-of-the-art approaches to analyze the genome and transcriptome, the genetic manipulation of cells and animals, and skeletal phenotyping. A key to the success of this approach will be to increase the number of investigators whose research is aligned with the scientific theme of the Center via development of junior investigators and recruitment of new and established investigators. We will establish the CMDR on a strong foundation of musculoskeletal research and implement an Organization and Management Plan to create a self-sustaining Center of Biomedical Research Excellence (Aim 1). We will also provide multidisciplinary development and unique research opportunities to young investigators and support them to the point of independence (Aim 2). Lastly, we will create diverse teams of productive investigators by providing access to effective and useful research cores that produce significant and long-lasting benefits to the research infrastructure of UAMS and its affiliated institutions (Aim 3). The Overall Center Organization and Management Plan includes the Administrative Core, three research cores, and four research projects, led by promising junior investigators. The Administrative Core will oversee establishment and operation of the center, the three research cores, and a faculty development plan. The integrated and interactive faculty development plan will include a formal mentoring program that will guide four junior investigators to independence. The CMDR research cores include a Genetic Models Core that will use cutting-edge approaches to genetically manipulate cells and mice, a Bone Histology and Imaging Core that will analyze mouse and human hard tissues, and a Bioinformatics Core that will analyze the large datasets generated by the molecular analyses of cells from mouse and human samples. Successful implementation of this Organization and Management Plan will in the long-term lead to a self-sustaining Center of Biomedical Research Excellence that will generate novel and important results leading to more effective therapies for a variety of conditions that involve the musculoskeletal system.

项目总结/文摘