Center for Musculoskeletal Disease Research (CMDR)
肌肉骨骼疾病研究中心 (CMDR)
基本信息
- 批准号:10117257
- 负责人:
- 金额:$ 227.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-02-16 至 2023-01-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnimalsArkansasBioinformaticsBone remodelingBreast cancer metastasisCellsCenters of Research ExcellenceClinicalClinical InvestigatorDegenerative polyarthritisDevelopmentDevelopment PlansDiseaseDoctor of PhilosophyEnvironmentFacultyFoundationsFundingGenetic ModelsGenomeGoalsGrantHealthHealth Care CostsHistologyHumanImageInstitutesInstitutionInternationalLeadMalignant NeoplasmsMedicalMedicineMentorsMethodsMolecular AnalysisMultiple MyelomaMusMusculoskeletalMusculoskeletal DiseasesMusculoskeletal SystemOrthopedicsOsteomyelitisOsteoporosisPathologicPatientsPhenotypePilot ProjectsPopulationProcessResearchResearch InfrastructureResearch PersonnelResearch Project GrantsSamplingScienceScientistSkeletonTeacher Professional DevelopmentTissuesUnited States National Institutes of HealthUniversitiesWorkbonedisabilityeffective therapyexperiencegenetic analysisgenetic manipulationlarge datasetsmalignant breast neoplasmmouse geneticsmultidisciplinarynegative affectnovelnovel therapeuticsoperationprofessorprogramsrecruitskeletalsuccesstranscriptome
项目摘要
PROJECT SUMMARY/ABSTRACT
Conditions such as osteoporosis, osteoarthritis, developmental abnormalities of the skeleton, as well as
malignancies, such as multiple myeloma and breast cancer metastases, all negatively affect the musculoskeletal
system. These conditions affect the health of a sizable percentage of the US population and lead to significant
disability and substantial health care costs, and there is an ongoing need to better understand their causes and
to support the development of more effective and well-tolerated therapies. To address this need, we propose to
establish and develop a thematic and multidisciplinary Center for Musculoskeletal Disease Research (CMDR)
at the University of Arkansas for Medical Sciences (UAMS). The scientific theme of the CMDR is that molecular
and genetic analysis of musculoskeletal diseases, and conditions that involve the skeleton as part of their disease
process, will lead to a better understanding of their causes and will support development of novel therapies. Our
approach to studying these conditions will take advantage of state-of-the-art approaches to analyze the genome
and transcriptome, the genetic manipulation of cells and animals, and skeletal phenotyping. A key to the success
of this approach will be to increase the number of investigators whose research is aligned with the scientific
theme of the Center via development of junior investigators and recruitment of new and established investigators.
We will establish the CMDR on a strong foundation of musculoskeletal research and implement an Organization
and Management Plan to create a self-sustaining Center of Biomedical Research Excellence (Aim 1). We will
also provide multidisciplinary development and unique research opportunities to young investigators and support
them to the point of independence (Aim 2). Lastly, we will create diverse teams of productive investigators by
providing access to effective and useful research cores that produce significant and long-lasting benefits to the
research infrastructure of UAMS and its affiliated institutions (Aim 3). The Overall Center Organization and
Management Plan includes the Administrative Core, three research cores, and four research projects, led by
promising junior investigators. The Administrative Core will oversee establishment and operation of the center,
the three research cores, and a faculty development plan. The integrated and interactive faculty development
plan will include a formal mentoring program that will guide four junior investigators to independence. The CMDR
research cores include a Genetic Models Core that will use cutting-edge approaches to genetically manipulate
cells and mice, a Bone Histology and Imaging Core that will analyze mouse and human hard tissues, and a
Bioinformatics Core that will analyze the large datasets generated by the molecular analyses of cells from mouse
and human samples. Successful implementation of this Organization and Management Plan will in the long-term
lead to a self-sustaining Center of Biomedical Research Excellence that will generate novel and important results
leading to more effective therapies for a variety of conditions that involve the musculoskeletal system.
项目总结/文摘
项目成果
期刊论文数量(0)
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CHARLES A O'BRIEN的其他文献
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{{ truncateString('CHARLES A O'BRIEN', 18)}}的其他基金
Center for Musculoskeletal Disease Research (CMDR)
肌肉骨骼疾病研究中心 (CMDR)
- 批准号:
10357772 - 财政年份:2018
- 资助金额:
$ 227.44万 - 项目类别:
Center for Musculoskeletal Disease Research (CMDR)
肌肉骨骼疾病研究中心 (CMDR)
- 批准号:
10495741 - 财政年份:2018
- 资助金额:
$ 227.44万 - 项目类别:
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