Dietary Biomarkers and Cardioprotective Mechanisms of the DASH-Sodium Diet.

DASH-钠饮食的膳食生物标志物和心脏保护机制。

• 批准号: 9587549
• 负责人: Casey Marie Rebholz
• 金额: $ 12.97万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9587549
• 关键词: Adult; American; American Heart Association; Applications Grants; Area; Atherosclerosis; Biological; Biological Assay; Biological Markers; Biomarker of Dietary Intake; Blood; Blood Pressure; C-reactive protein; Cardiac health; Cardiovascular Diseases; Cessation of life; Cholesterol; Collaborations; Collection; DASH diet; Dairy Products; Data; Development; Diet; Dietary Assessment; Dietary Factors; Dietary Intervention; Dietary Practices; Dietary Sodium; Disease; Doctor of Philosophy; Dose; Event; Fatty acid glycerol esters; Fingerprint; Food; Funding; Future; Goals; Guide prevention; Health Benefit; Health Promotion; Heart; Hour; Hypertension; Individual; Inflammation; Inflammatory; Intervention; Lesion; Levocarnitine; Meat; Mediating; Mediator of activation protein; Metabolic; Metabolism; Methodology; Minerals; National Heart, Lung, and Blood Institute; Nutrient; Participant; Pathogenesis; Pathway interactions; Phase; Phosphorus; Physiological; Positioning Attribute; Principal Investigator; Process; Public Health Schools; Randomized; Randomized Clinical Trials; Research; Research Personnel; Research Proposals; Risk; Risk Factors; Serum; Sodium; Sodium-Restricted Diet; Specimen; Testing; Therapeutic; Urine; Urokinase Plasminogen Activator Receptor; Vascular calcification; biobank; blood pressure reduction; cardiometabolism; cardioprotection; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cost effective; dietary approach; dietary guidelines; feeding; fibroblast growth factor 23; food consumption; fruits and vegetables; good diet; improved; insight; metabolome; metabolomics; modifiable risk; mortality; novel; novel marker; nutritional epidemiology; professor; saturated fat; tenure track; trimethyloxamine

PROJECT SUMMARY / ABSTRACT More than 1 in 3 U.S. adults have cardiovascular disease. Dietary factors contributed to nearly half of all cardiometabolic deaths in 2012. The DASH-sodium diet is a dietary pattern that is high in fruits, vegetables, and low-fat dairy products and low in sodium, saturated fat, and cholesterol which lowers blood pressure and has also been shown to reduce the risk of hypertension, cardiovascular disease, and mortality. The American Heart Association recommends the DASH-sodium dietary pattern for the prevention of cardiovascular disease. This cost-effective proposal maximizes the scientific value of the existing data and specimens from the multi-center, randomized, controlled DASH-sodium feeding study by conducting high-impact and novel biomarker research. We propose to conduct untargeted metabolomics and targeted assays of mineral metabolism [fibroblast growth factor-23 (FGF-23) and phosphorus] and inflammation [C-reactive protein (CRP) and soluble urokinase-type plasminogen activator receptor (suPAR)] using serum specimens collected at the end of the intervention phase for the low-sodium DASH diet and the high-sodium control diet (N=393). These sodium phases within each dietary pattern were selected to maximize the contrast and to reflect a comparison between the recommended diet for cardioprotection vs. the typical U.S. diet. The specific aims of the research proposal are: 1) to characterize the serum metabolomic fingerprint of the DASH-sodium dietary pattern; 2) to identify serum metabolomic mediators of the blood pressure lowering effect of the DASH-sodium dietary pattern; and 3) to determine the effect of the DASH-sodium diet on intermediate markers of cardiovascular risk (serum levels of FGF-23, phosphorus, CRP, suPAR). The Principal Investigator, Casey M. Rebholz, PhD, MS, MPH, is a K01-funded early stage investigator with a tenure-track position as an Assistant Professor at Johns Hopkins Bloomberg School of Public Health. Preliminary findings in the original DASH feeding study provide compelling support for the current proposal. Collaboration with established investigators in relevant research areas (nutritional epidemiology, biomarkers research, metabolomics, and feeding studies) will catalyze the proposed research. The NHBLI BioLINCC has approved the request for DASH-sodium data and specimens for this proposed research. The proposed research will advance dietary assessment methodology and provide novel insights into diet- modifiable cardiovascular disease pathogenesis with the goal of guiding prevention and therapeutic approaches through diet, to be tested in future grant proposals by Dr. Rebholz. Strengthening the evidence for cardioprotective diets through the proposed research constitutes an opportunity to improve the heart health of millions of Americans.

项目摘要 /摘要 美国三分之一以上的成年人患有心血管疾病。饮食因素造成了几乎一半的饮食因素 心脏代谢死亡2012年。仪表降解饮食是一种饮食模式，水果，蔬菜， 和低脂乳制品和低钠，饱和脂肪和胆固醇的低脂肪，可降低血压和 还显示出可降低高血压，心血管疾病和死亡率的风险。美国人 心脏协会建议采用仪表降临饮食模式，以预防心血管疾病。 这项具有成本效益的建议最大化了现有数据的科学价值和标本 多中心，随机，受控的仪表座饲料研究，通过进行高影响力和新颖 生物标志物研究。我们建议进行不靶向的代谢组学和矿物的目标测定 代谢[成纤维细胞生长因子23（FGF-23）和磷]和炎症[C反应蛋白（CRP） 和使用在该的血清标本中收集的血清标本和可溶性尿激酶型纤溶酶原活化剂受体（SUPAR）] 低钠仪表式饮食和高钠控制饮食的干预阶段结束（n = 393）。这些 选择了每种饮食模式中的钠相，以最大化对比度并反映比较 在建议的心脏保护饮食与典型的美国饮食之间。研究的具体目的 提案是：1）表征仪表式饮食模式的血清代谢组指纹； 2）到 确定dash-饮食的血压降低效应的血清代谢组介质 图案; 3）确定仪表降解饮食对心血管风险中间标记的影响 （FGF-23的血清水平，磷，CRP，Supar）。 首席研究员Casey M. Rebholz博士，MS，MPH是K01资助的早期研究员 在约翰·霍普金斯彭博公共卫生学院担任助理教授的任期职位。 原始破折号喂养研究中的初步发现为当前建议提供了令人信服的支持。 与相关研究领域的既定研究者（营养流行病学，生物标志物）合作 研究，代谢组学和喂养研究将催化拟议的研究。 NHBLI Biolincc有 批准了该拟议研究的仪表馆数据和标本的请求。 拟议的研究将推进饮食评估方法，并为饮食提供新的见解。 可修改的心血管疾病发病机理，目的是指导预防和治疗 通过饮食方法，将在Rebholz博士的未来赠款建议中进行测试。加强证据 通过拟议研究的心脏保护饮食构成了改善心脏健康的机会 数百万美国人。