Dietary Biomarkers and Cardioprotective Mechanisms of the DASH-Sodium Diet.

DASH-钠饮食的膳食生物标志物和心脏保护机制。

• 批准号: 9587549
• 负责人: Casey Marie Rebholz
• 金额: $ 12.97万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9587549
• 关键词: Adult; American; American Heart Association; Applications Grants; Area; Atherosclerosis; Biological; Biological Assay; Biological Markers; Biomarker of Dietary Intake; Blood; Blood Pressure; C-reactive protein; Cardiac health; Cardiovascular Diseases; Cessation of life; Cholesterol; Collaborations; Collection; DASH diet; Dairy Products; Data; Development; Diet; Dietary Assessment; Dietary Factors; Dietary Intervention; Dietary Practices; Dietary Sodium; Disease; Doctor of Philosophy; Dose; Event; Fatty acid glycerol esters; Fingerprint; Food; Funding; Future; Goals; Guide prevention; Health Benefit; Health Promotion; Heart; Hour; Hypertension; Individual; Inflammation; Inflammatory; Intervention; Lesion; Levocarnitine; Meat; Mediating; Mediator of activation protein; Metabolic; Metabolism; Methodology; Minerals; National Heart, Lung, and Blood Institute; Nutrient; Participant; Pathogenesis; Pathway interactions; Phase; Phosphorus; Physiological; Positioning Attribute; Principal Investigator; Process; Public Health Schools; Randomized; Randomized Clinical Trials; Research; Research Personnel; Research Proposals; Risk; Risk Factors; Serum; Sodium; Sodium-Restricted Diet; Specimen; Testing; Therapeutic; Urine; Urokinase Plasminogen Activator Receptor; Vascular calcification; biobank; blood pressure reduction; cardiometabolism; cardioprotection; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cost effective; dietary approach; dietary guidelines; feeding; fibroblast growth factor 23; food consumption; fruits and vegetables; good diet; improved; insight; metabolome; metabolomics; modifiable risk; mortality; novel; novel marker; nutritional epidemiology; professor; saturated fat; tenure track; trimethyloxamine

PROJECT SUMMARY / ABSTRACT More than 1 in 3 U.S. adults have cardiovascular disease. Dietary factors contributed to nearly half of all cardiometabolic deaths in 2012. The DASH-sodium diet is a dietary pattern that is high in fruits, vegetables, and low-fat dairy products and low in sodium, saturated fat, and cholesterol which lowers blood pressure and has also been shown to reduce the risk of hypertension, cardiovascular disease, and mortality. The American Heart Association recommends the DASH-sodium dietary pattern for the prevention of cardiovascular disease. This cost-effective proposal maximizes the scientific value of the existing data and specimens from the multi-center, randomized, controlled DASH-sodium feeding study by conducting high-impact and novel biomarker research. We propose to conduct untargeted metabolomics and targeted assays of mineral metabolism [fibroblast growth factor-23 (FGF-23) and phosphorus] and inflammation [C-reactive protein (CRP) and soluble urokinase-type plasminogen activator receptor (suPAR)] using serum specimens collected at the end of the intervention phase for the low-sodium DASH diet and the high-sodium control diet (N=393). These sodium phases within each dietary pattern were selected to maximize the contrast and to reflect a comparison between the recommended diet for cardioprotection vs. the typical U.S. diet. The specific aims of the research proposal are: 1) to characterize the serum metabolomic fingerprint of the DASH-sodium dietary pattern; 2) to identify serum metabolomic mediators of the blood pressure lowering effect of the DASH-sodium dietary pattern; and 3) to determine the effect of the DASH-sodium diet on intermediate markers of cardiovascular risk (serum levels of FGF-23, phosphorus, CRP, suPAR). The Principal Investigator, Casey M. Rebholz, PhD, MS, MPH, is a K01-funded early stage investigator with a tenure-track position as an Assistant Professor at Johns Hopkins Bloomberg School of Public Health. Preliminary findings in the original DASH feeding study provide compelling support for the current proposal. Collaboration with established investigators in relevant research areas (nutritional epidemiology, biomarkers research, metabolomics, and feeding studies) will catalyze the proposed research. The NHBLI BioLINCC has approved the request for DASH-sodium data and specimens for this proposed research. The proposed research will advance dietary assessment methodology and provide novel insights into diet- modifiable cardiovascular disease pathogenesis with the goal of guiding prevention and therapeutic approaches through diet, to be tested in future grant proposals by Dr. Rebholz. Strengthening the evidence for cardioprotective diets through the proposed research constitutes an opportunity to improve the heart health of millions of Americans.

项目总结/摘要 超过三分之一的美国成年人患有心血管疾病。饮食因素占近一半 2012年的心脏病死亡人数DASH钠饮食是一种富含水果，蔬菜， 低脂奶制品，低钠，饱和脂肪和胆固醇，降低血压， 还被证明可以降低高血压、心血管疾病和死亡率的风险。美国 心脏协会推荐DASH-钠饮食模式用于预防心血管疾病。 这一具有成本效益的建议最大限度地提高了现有数据和标本的科学价值， 多中心、随机、对照DASH-钠喂养研究，通过开展高影响力和新的 生物标志物研究我们建议进行非靶向代谢组学和矿物质的靶向测定， 代谢[成纤维细胞生长因子-23（FGF-23）和磷]和炎症[C-反应蛋白（CRP）] 和可溶性尿激酶型纤溶酶原激活物受体（suPAR）]使用在 低钠DASH饮食和高钠对照饮食干预阶段结束时（N=393）。这些 选择每种饮食模式中的钠阶段，以最大化对比并反映比较 推荐的心脏保护饮食与典型的美国饮食之间的差异。研究的具体目标 建议是：1）表征DASH-钠饮食模式的血清代谢指纹; 2） 确定DASH-钠膳食降血压作用的血清代谢组学介质 模式; 3）确定DASH钠饮食对心血管风险中间标志物的影响 （FGF-23、磷、CRP、suPAR的血清水平）。 首席研究员，凯西M。Rebholz博士，MS，MPH，是K 01资助的早期研究员 在约翰霍普金斯布隆伯格公共卫生学院担任助理教授， 最初的DASH喂养研究的初步结果为当前的提议提供了令人信服的支持。 与相关研究领域（营养流行病学、生物标志物）的知名研究者合作 研究、代谢组学和喂养研究）将促进拟议的研究。NHBLI BioLINCC拥有 批准了这项拟议研究的DASH钠数据和样本请求。 拟议的研究将推进饮食评估方法，并提供新的见解，饮食- 以指导预防和治疗为目标的可改变的心血管疾病发病机制 通过饮食的方法，将在未来的资助建议由Rebholz博士测试。加强证据， 通过拟议的研究，心脏保护饮食构成了改善心脏健康的机会， 数百万美国人。