Dietary Biomarkers and Cardioprotective Mechanisms of the DASH-Sodium Diet.

DASH-钠饮食的膳食生物标志物和心脏保护机制。

• 批准号: 9587549
• 负责人: Casey Marie Rebholz
• 金额: $ 12.97万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9587549
• 关键词: Adult; American; American Heart Association; Applications Grants; Area; Atherosclerosis; Biological; Biological Assay; Biological Markers; Biomarker of Dietary Intake; Blood; Blood Pressure; C-reactive protein; Cardiac health; Cardiovascular Diseases; Cessation of life; Cholesterol; Collaborations; Collection; DASH diet; Dairy Products; Data; Development; Diet; Dietary Assessment; Dietary Factors; Dietary Intervention; Dietary Practices; Dietary Sodium; Disease; Doctor of Philosophy; Dose; Event; Fatty acid glycerol esters; Fingerprint; Food; Funding; Future; Goals; Guide prevention; Health Benefit; Health Promotion; Heart; Hour; Hypertension; Individual; Inflammation; Inflammatory; Intervention; Lesion; Levocarnitine; Meat; Mediating; Mediator of activation protein; Metabolic; Metabolism; Methodology; Minerals; National Heart, Lung, and Blood Institute; Nutrient; Participant; Pathogenesis; Pathway interactions; Phase; Phosphorus; Physiological; Positioning Attribute; Principal Investigator; Process; Public Health Schools; Randomized; Randomized Clinical Trials; Research; Research Personnel; Research Proposals; Risk; Risk Factors; Serum; Sodium; Sodium-Restricted Diet; Specimen; Testing; Therapeutic; Urine; Urokinase Plasminogen Activator Receptor; Vascular calcification; biobank; blood pressure reduction; cardiometabolism; cardioprotection; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cost effective; dietary approach; dietary guidelines; feeding; fibroblast growth factor 23; food consumption; fruits and vegetables; good diet; improved; insight; metabolome; metabolomics; modifiable risk; mortality; novel; novel marker; nutritional epidemiology; professor; saturated fat; tenure track; trimethyloxamine

PROJECT SUMMARY / ABSTRACT More than 1 in 3 U.S. adults have cardiovascular disease. Dietary factors contributed to nearly half of all cardiometabolic deaths in 2012. The DASH-sodium diet is a dietary pattern that is high in fruits, vegetables, and low-fat dairy products and low in sodium, saturated fat, and cholesterol which lowers blood pressure and has also been shown to reduce the risk of hypertension, cardiovascular disease, and mortality. The American Heart Association recommends the DASH-sodium dietary pattern for the prevention of cardiovascular disease. This cost-effective proposal maximizes the scientific value of the existing data and specimens from the multi-center, randomized, controlled DASH-sodium feeding study by conducting high-impact and novel biomarker research. We propose to conduct untargeted metabolomics and targeted assays of mineral metabolism [fibroblast growth factor-23 (FGF-23) and phosphorus] and inflammation [C-reactive protein (CRP) and soluble urokinase-type plasminogen activator receptor (suPAR)] using serum specimens collected at the end of the intervention phase for the low-sodium DASH diet and the high-sodium control diet (N=393). These sodium phases within each dietary pattern were selected to maximize the contrast and to reflect a comparison between the recommended diet for cardioprotection vs. the typical U.S. diet. The specific aims of the research proposal are: 1) to characterize the serum metabolomic fingerprint of the DASH-sodium dietary pattern; 2) to identify serum metabolomic mediators of the blood pressure lowering effect of the DASH-sodium dietary pattern; and 3) to determine the effect of the DASH-sodium diet on intermediate markers of cardiovascular risk (serum levels of FGF-23, phosphorus, CRP, suPAR). The Principal Investigator, Casey M. Rebholz, PhD, MS, MPH, is a K01-funded early stage investigator with a tenure-track position as an Assistant Professor at Johns Hopkins Bloomberg School of Public Health. Preliminary findings in the original DASH feeding study provide compelling support for the current proposal. Collaboration with established investigators in relevant research areas (nutritional epidemiology, biomarkers research, metabolomics, and feeding studies) will catalyze the proposed research. The NHBLI BioLINCC has approved the request for DASH-sodium data and specimens for this proposed research. The proposed research will advance dietary assessment methodology and provide novel insights into diet- modifiable cardiovascular disease pathogenesis with the goal of guiding prevention and therapeutic approaches through diet, to be tested in future grant proposals by Dr. Rebholz. Strengthening the evidence for cardioprotective diets through the proposed research constitutes an opportunity to improve the heart health of millions of Americans.

项目摘要/摘要