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Metabolomic Markers of Dietary Factors Associated with Kidney Health

与肾脏健康相关的饮食因素的代谢组学标志物

基本信息

批准号：
10333394
负责人：
Casey Marie Rebholz
金额：
$ 12.28万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10333394
关键词：
Acids Adherence African American Animal Sources Animals Applications Grants Atherosclerosis Risk in Communities Biological Markers Biomarker of Dietary Intake Chronic Kidney Failure Clinical Clinical Trials Communities Dairy Products Data Data Reporting Diet Diet Modification Dietary Assessment Dietary Factors Dietary Intervention Dietary Practices Dietary Proteins Dietary intake Disease Outcome Edible Plants Equilibrium Fabaceae Fatty acid glycerol esters Food Funding General Population Goals Grant Guidelines Health Human Resources Hypertension Incidence Intake Intervention Intervention Trial Kidney Kidney Diseases Mediating Mediation Mediator of activation protein Metabolic Metabolic Marker Metabolic Pathway Morbidity - disease rate National Institute of Diabetes and Digestive and Kidney Diseases Nutrient Nuts Onset of illness Outcome Patient Self-Report Patients Physiological Plants Population Prevention strategy Processed Meats Proteins Public Health Randomized Clinical Trials Reporting Research Research Design Research Personnel Research Proposals Risk Risk Factors Source Testing Training Vegetable Proteins Vegetables Woman base biomarker discovery candidate marker career clinically relevant cohort cost effective design dietary dietary guidelines disorder prevention disorder risk effective therapy evidence base follow-up fruits and vegetables high risk high throughput technology improved men metabolomics middle age modifiable risk mortality novel novel marker nutritional epidemiology protein biomarkers protein metabolite small molecule study population

项目摘要

PROJECT SUMMARY / ABSTRACT Chronic kidney disease is associated with high rates of the morbidity and mortality, but few effective therapies exist. Diet is central to kidney disease and its management, and is a modifiable risk factor for kidney disease onset and its progression. Metabolomics can now quantify hundreds of small molecules in an unbiased approach providing an opportunity to assess the proximal physiologic effect of diet and to identify diet-modifiable metabolic pathways leading to kidney disease. The specific aims of the research proposal are: 1) to assess metabolomic markers of protein sources in a general population and evaluate mediation of protein and CKD risk by metabolites; 2) to externally validate purported metabolic markers of dietary acid load in an independent study population and to examine metabolomic mediators of CKD risk; and 3) to identify biomarkers of plant-based diets and determine which biomarkers explain the association between plant-based diets and CKD. Whereas previous clinical guidelines for kidney disease patients have recommended restriction of overall protein and other nutrients, we will focus on novel dietary factors, including specific protein sources, dietary acid load, and plant-based diets, which have been recently shown to be related to kidney disease risk. The analyses to be conducted will strengthen the evidence for clinically-relevant aspects of the diet that mediate kidney disease risk to be pursued in a diet intervention trial. The proposed research leverages existing metabolomics, dietary, and kidney disease outcome data in the Atherosclerosis Risk in Communities (ARIC) study, a well-characterized cohort of middle-aged black and white men and women from four U.S. communities. The successful completion of the project is assured given the existing approval from the ARIC study, access to data, and personnel with the necessary training and expertise. The proposed research, if funded, will greatly advance dietary assessment and will elucidate compounds and their metabolic pathways implicated in the diet-kidney disease relationship. The anticipated results of this project will lend support for a subsequent R01 grant application by refining the essential components of an improved renal diet and identify mediators that could be assessed as intermediate outcomes in a diet intervention trial. In summary, this grant will catalyze the next career stage for a NIDDK K01-funded investigator and has the potential to reduce the public health burden of kidney disease.

项目摘要/摘要