Metabolomic Markers of Dietary Factors Associated with Kidney Health
Metabolomic Markers of Dietary Factors Associated with Kidney Health
批准号:
10191255
负责人:
Casey Marie Rebholz
金额:
$12.28万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-04-01 至 2023-03-31
关键词:
AcidsAdherenceAfrican AmericanAnimal SourcesAnimalsApplications GrantsAtherosclerosis Risk in CommunitiesBiological MarkersBiomarker of Dietary IntakeChronic Kidney FailureClinicalClinical TrialsCommunitiesDairy ProductsDataData ReportingDietDiet ModificationDietary AssessmentDietary FactorsDietary InterventionDietary PracticesDietary ProteinsDietary intakeDisease OutcomeEdible PlantsEquilibriumFabaceaeFatty acid glycerol estersFoodFundingGeneral PopulationGoalsGrantGuidelinesHealthHuman ResourcesHypertensionIncidenceIntakeInterventionIntervention TrialKidneyKidney DiseasesMediatingMediationMediator of activation proteinMetabolicMetabolic MarkerMetabolic PathwayMorbidity - disease rateNational Institute of Diabetes and Digestive and Kidney DiseasesNutrientNutsOnset of illnessOutcomePatient Self-ReportPatientsPhysiologicalPlantsPopulationPrevention strategyProcessed MeatsProteinsPublic HealthRandomized Clinical TrialsReportingResearchResearch DesignResearch PersonnelResearch ProposalsRiskRisk FactorsSourceTestingTrainingVegetable ProteinsVegetablesWomanbasebiomarker discoverycandidate markercareerclinically relevantcohortcost effectivedesigndietarydietary guidelinesdisorder preventiondisorder riskeffective therapyevidence basefollow-upfruits and vegetableshigh riskhigh throughput technologyimprovedmenmetabolomicsmiddle agemodifiable riskmortalitynovelnovel markernutritional epidemiologyprotein biomarkersprotein metabolitesmall moleculestudy population
中文摘要
项目摘要/摘要
英文摘要
PROJECT SUMMARY / ABSTRACT
Chronic kidney disease is associated with high rates of the morbidity and mortality, but few effective
therapies exist. Diet is central to kidney disease and its management, and is a modifiable risk factor for kidney
disease onset and its progression. Metabolomics can now quantify hundreds of small molecules in an
unbiased approach providing an opportunity to assess the proximal physiologic effect of diet and to identify
diet-modifiable metabolic pathways leading to kidney disease.
The specific aims of the research proposal are: 1) to assess metabolomic markers of protein sources in a
general population and evaluate mediation of protein and CKD risk by metabolites; 2) to externally validate
purported metabolic markers of dietary acid load in an independent study population and to examine
metabolomic mediators of CKD risk; and 3) to identify biomarkers of plant-based diets and determine which
biomarkers explain the association between plant-based diets and CKD.
Whereas previous clinical guidelines for kidney disease patients have recommended restriction of overall
protein and other nutrients, we will focus on novel dietary factors, including specific protein sources, dietary
acid load, and plant-based diets, which have been recently shown to be related to kidney disease risk. The
analyses to be conducted will strengthen the evidence for clinically-relevant aspects of the diet that mediate
kidney disease risk to be pursued in a diet intervention trial.
The proposed research leverages existing metabolomics, dietary, and kidney disease outcome data in the
Atherosclerosis Risk in Communities (ARIC) study, a well-characterized cohort of middle-aged black and white
men and women from four U.S. communities. The successful completion of the project is assured given the
existing approval from the ARIC study, access to data, and personnel with the necessary training and
expertise.
The proposed research, if funded, will greatly advance dietary assessment and will elucidate compounds
and their metabolic pathways implicated in the diet-kidney disease relationship. The anticipated results of this
project will lend support for a subsequent R01 grant application by refining the essential components of an
improved renal diet and identify mediators that could be assessed as intermediate outcomes in a diet
intervention trial. In summary, this grant will catalyze the next career stage for a NIDDK K01-funded
investigator and has the potential to reduce the public health burden of kidney disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Discovery, Replication, and Validation of Biomarkers of the DASH Diet and Hypertension
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批准号:10478910
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项目类别:
-
资助金额:$73.39万
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财政年份:2021
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负责人:Casey Marie Rebholz
-
依托单位:
Discovery, Replication, and Validation of Biomarkers of the DASH Diet and Hypertension
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批准号:10829021
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项目类别:
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资助金额:$16.38万
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财政年份:2021
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负责人:Casey Marie Rebholz
-
依托单位:
Metabolomic Markers of Dietary Factors Associated with Kidney Health
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批准号:10333394
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项目类别:
-
资助金额:$12.28万
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财政年份:2021
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负责人:Casey Marie Rebholz
-
依托单位:
Discovery, Replication, and Validation of Biomarkers of the DASH Diet and Hypertension
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批准号:10678862
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项目类别:
-
资助金额:$70.42万
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财政年份:2021
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负责人:Casey Marie Rebholz
-
依托单位:
Discovery, Replication, and Validation of Biomarkers of the DASH Diet and Hypertension
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批准号:10532973
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项目类别:
-
资助金额:$7.42万
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财政年份:2021
-
负责人:Casey Marie Rebholz
-
依托单位:
Discovery, Replication, and Validation of Biomarkers of the DASH Diet and Hypertension
-
批准号:10295307
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项目类别:
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资助金额:$74.6万
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财政年份:2021
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负责人:Casey Marie Rebholz
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依托单位:
Dietary Biomarkers and Cardioprotective Mechanisms of the DASH-Sodium Diet.
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批准号:9587549
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项目类别:
-
资助金额:$12.97万
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财政年份:2018
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负责人:Casey Marie Rebholz
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依托单位:
Metabolomics for Identifying Biomarkers of Dietary Intake & Kidney Disease Progression
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批准号:9351513
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项目类别:
-
资助金额:$15.49万
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财政年份:2016
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负责人:Casey Marie Rebholz
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依托单位:
Metabolomics for Identifying Biomarkers of Dietary Intake & Kidney Disease Progression
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批准号:9179786
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项目类别:
-
资助金额:$15.65万
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财政年份:2016
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负责人:Casey Marie Rebholz
-
依托单位:
海外基金