Neural and cognitive consequences of COVID-19 survival.

SARS-CoV-2疫情在全球范围内已经持续了一年多，有1.15亿人 确诊病例和超过250万人死亡(截至2021年3月3日)。我们看到人们正在康复 从最初的COVID19感染到对持续问题的抱怨。越来越多的 人们抱怨认知缺陷和抑郁/焦虑。退伍军人面临的风险更高 他不仅患有柯萨奇病毒19，还患有多种合并症。 有神经认知并发症的退伍军人可能会经历过早衰老和 神经退行性变可能会给医疗保健带来巨大负担。 我们联合了两个实验室，使用脑电研究神经认知障碍， 核磁共振、行为方法以及基于实验室的数据。福特实验室提议质疑 计算机网络神经心理学对退伍军人神经心理功能的影响 电池、基于EEG的测量、功能MRI(连通性)和结构MRI(灰色和白色 物质体积、髓鞘、微量出血)。Pulliam实验室的初步数据显示， COVID19存活者血浆细胞因子水平升高。血浆分离神经元富集物 细胞外小泡(NEVS)表现为淀粉样β蛋白、神经细丝光和pT181- Tau，所有与神经退化有关的蛋白质。总体目标是确定程度 对COVID19恢复者的认知、临床和神经损害的研究。 具体目的是：1)研究COVID19幸存者的神经心理功能；2) 评估COVID19幸存者的EEG和MRI数据，3)确定外周炎症 神经炎症、衰老和神经变性的标记物在NEV中持续存在，4)探索 神经退行性和炎性血液标志物与EEG/MRI/NP的关系 在考虑先前存在的COVID19的并存和并发症的同时采取措施。

The SARS-CoV-2 pandemic has been going on for over a year worldwide, with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). We are seeing people recover from the initial COVID19 infection with complaints of ongoing problems. An increasing number of people are complaining of cognitive deficits and depression/anxiety. Veterans are at a higher risk of COVID19 infection as well as suffering complications due to a number of co-morbidities. Veterans with neurocognitive complications may experience premature aging and neurodegeneration that could manifest as a huge burden for health care. We have brought together two laboratories studying neurocognitive impairment using an EEG, MRI, and behavioral approach as well as laboratory-based data. The Ford lab proposes to query neuropsychological function in Veterans using a computerized internet-based neuropsychological battery, EEG-based measures, functional MRI (connectivity) and structural MRI (gray and white matter volumes, myelin, micro-bleeds). The Pulliam lab has preliminary data to show a continued increase in plasma cytokines in COVID19 survivors. Plasma isolated neuronal enriched extracellular vesicles (nEVs) showed an increase in amyloid beta, neurofilament light and pT181- Tau, all proteins associated with neurodegeneration. The Overall Aim is to determine the extent of the cognitive, clinical, and neurological damage in people recovered from COVID19. The Specific Aims are to: 1) characterize neuropsychological function in COVID19 survivors, 2) assess EEG and MRI data in COVID19 survivors, 3) determine whether peripheral inflammation and markers of neuroinflammation, aging, and neurodegeneration persist in nEVs, and 4) explore relationships between neurodegenerative and inflammatory blood markers and EEG/MRI/NP measures while considering pre-existing co-morbidities and complications of COVID19.