Neural and cognitive consequences of COVID-19 survival.

SARS-CoV-2大流行已经在全世界持续了一年多， 确诊病例和超过2，500，000例死亡（截至2021年3月3日）。我们看到人们正在恢复 从最初的COVID 19感染与投诉的持续问题。越来越多的 人们抱怨认知缺陷和抑郁/焦虑。退伍军人的风险更高 COVID 19感染以及由于一些合并症而遭受并发症。 患有神经认知并发症的退伍军人可能会过早衰老， 神经退行性疾病可能会成为医疗保健的巨大负担。 我们将两个实验室联合起来，使用脑电图研究神经认知障碍， MRI和行为方法以及实验室数据。福特实验室提出质疑 神经心理学功能在退伍军人使用计算机化的基于互联网的神经心理学 电池、基于EEG的测量、功能MRI（连通性）和结构MRI（灰色和白色 物质体积、髓磷脂、微出血）。普利亚姆实验室的初步数据显示， COVID 19幸存者的血浆细胞因子增加。血浆分离的神经元富集 细胞外囊泡（nEV）显示淀粉样蛋白β，神经丝光和pT 181- 所有与神经变性相关的蛋白质。总体目标是确定 从COVID 19中康复的人的认知，临床和神经损伤。 具体目的是：1）表征COVID 19幸存者的神经心理功能，2） 评估COVID 19幸存者的EEG和MRI数据，3）确定外周炎症是否 神经炎症、衰老和神经变性的标志物在nEV中持续存在，以及4）探索 神经退行性和炎症性血液标志物与EEG/MRI/NP之间的关系 同时考虑COVID 19的既存合并症和并发症。

The SARS-CoV-2 pandemic has been going on for over a year worldwide, with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). We are seeing people recover from the initial COVID19 infection with complaints of ongoing problems. An increasing number of people are complaining of cognitive deficits and depression/anxiety. Veterans are at a higher risk of COVID19 infection as well as suffering complications due to a number of co-morbidities. Veterans with neurocognitive complications may experience premature aging and neurodegeneration that could manifest as a huge burden for health care. We have brought together two laboratories studying neurocognitive impairment using an EEG, MRI, and behavioral approach as well as laboratory-based data. The Ford lab proposes to query neuropsychological function in Veterans using a computerized internet-based neuropsychological battery, EEG-based measures, functional MRI (connectivity) and structural MRI (gray and white matter volumes, myelin, micro-bleeds). The Pulliam lab has preliminary data to show a continued increase in plasma cytokines in COVID19 survivors. Plasma isolated neuronal enriched extracellular vesicles (nEVs) showed an increase in amyloid beta, neurofilament light and pT181- Tau, all proteins associated with neurodegeneration. The Overall Aim is to determine the extent of the cognitive, clinical, and neurological damage in people recovered from COVID19. The Specific Aims are to: 1) characterize neuropsychological function in COVID19 survivors, 2) assess EEG and MRI data in COVID19 survivors, 3) determine whether peripheral inflammation and markers of neuroinflammation, aging, and neurodegeneration persist in nEVs, and 4) explore relationships between neurodegenerative and inflammatory blood markers and EEG/MRI/NP measures while considering pre-existing co-morbidities and complications of COVID19.