Core A - Resource for Clinical Studies of AKI

核心 A - AKI 临床研究资源

• 批准号: 10456258
• 负责人: Ravindra L. Mehta
• 金额: $ 29.94万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456258
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Adult; Basic Science; Benchmarking; Biological; Biological Assay; Biological Markers; Biometry; Blood; Cardiac Catheterization Procedures; Cardiac Surgery procedures; Caring; Case Report Form; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Sciences; Coupled; DNA; Data; Data Analyses; Data Management Resources; Data Set; Database Management Systems; Databases; Disease; Educational workshop; Epidemiology; Functional disorder; Funding; Goals; Grant; Human; Individual; Injury to Kidney; International; Intervention Studies; Kidney; Kidney Diseases; Knowledge; Link; Natural History; Normal tissue morphology; Online Systems; Oranges; Outcome; Outcomes Research; Pathway interactions; Patient-Focused Outcomes; Patients; Peer Review; Pharmaceutical Preparations; Phase; Phenotype; Prevention; Protocols documentation; Publications; Registries; Research; Research Institute; Research Personnel; Research Support; Resources; Sampling; Services; Site; System; Tissues; Training and Education; Translational Research; Translations; Transplantation; Urine; base; biobank; catalyst; clinical database; clinical investigation; cloud based; data acquisition; data mining; design; flexibility; follow-up; improved outcome; injury and repair; insight; international center; investigator training; mobile application; multiple data sources; novel; pre-clinical; repository; research study; response; symposium; tool; trial design

Project Summary Clinical and translational research in acute kidney injury (AKI) requires access to well characterized patients with longitudinal follow up coupled with biological samples enabling investigators to probe the underlying mechanisms and pathways contributing to outcomes. The specific aims of the Resource for Clinical Studies of AKI (Core A) are to (i) facilitate and support the design and conduct of clinical research in AKI with appropriate tools to collect and record information for detailed phenotypic characterization of patients through the course of AKI, (ii) provide access to comprehensive datasets of well characterized patients with and without AKI, and (iii) provide a biological sample repository that includes human kidney tissue, blood and urine, linked to an accessible clinical database of patients with and without AKI to enable translational research studies. This core will specifically provide investigators access to patients with AKI through an established international network of collaborating investigators who are contributing to an ongoing registry of AKI in the ICU setting currently with over 2,200 patients. Core A is designed to facilitate both hypothesis-driven and hypothesis-generating clinical research by providing essential resources for clinical investigation and enhancing interactions with a large worldwide network of investigators and centers focused on AKI. Since its inception the Core has been very successful in supporting investigators for clinical and translational research. We have established a robust data management system and database of patients with AKI that is flexible in accommodating the research objectives of individual investigators and collaborating centers. A new service being offered by Core A is the addition of human kidney tissues along with biological samples (blood, urine and DNA) from patients with and without AKI and healthy controls. Over the last 4 years, Core A has been highly productive in assisting multiple facets of clinical research supporting 72 investigators including 8 pilot and catalyst awardees and 111 different projects. These combined efforts have resulted in 40 peer-reviewed publications. All services provided by Core A are being utilized by our investigator base. We envision that these rich resources will continue to enable interdisciplinary clinical investigation in AKI to advance our understanding of the natural history and pathophysiology of human AKI. We are confident that Core A in conjunction with the existing resources at UAB and UCSD and other cores within the O'Brien Center will accelerate the translation of new investigative insights towards improving outcomes for patients with AKI.

项目摘要 急性肾损伤（阿基）的临床和转化研究需要获得充分表征的 患者纵向随访加上生物样本，使研究者能够探测 有助于取得成果的基本机制和途径。临床资源的具体目标 阿基研究（核心A）旨在（i）促进和支持阿基临床研究的设计和实施， 适当的工具来收集和记录患者的详细表型表征信息， 阿基的过程，（ii）提供对具有良好特征的患者的综合数据集的访问， 没有阿基，和（iii）提供包括人肾组织、血液和尿液的生物样品储存库， 与AKI患者和非阿基患者的可访问临床数据库链接，以进行转化研究 问题研究该核心将专门为研究者提供访问阿基患者的途径， 国际合作研究者网络，为ICU中正在进行的阿基登记做出贡献 目前有2,200多名患者。核心A旨在促进假设驱动和 通过为临床研究提供必要的资源， 加强与关注阿基的大型全球研究者和中心网络的互动。 自成立以来，核心一直非常成功地支持研究者进行临床和 翻译研究我们建立了一个强大的数据管理系统和患者数据库， 阿基在适应个体研究者的研究目标和协作方面具有灵活性 中心.核心A提供的一项新服务是将人类肾脏组织沿着生物学检查， 来自患有和不患有阿基的患者以及健康对照的样本（血液、尿液和DNA）。在过去的四年里， 核心A在支持72名研究者的临床研究的多个方面方面具有很高的生产力 包括8个试点和催化剂获奖者和111个不同的项目。这些共同的努力导致了40 同行评审的出版物。核心A提供的所有服务都被我们的研究者基地使用。我们 我们设想，这些丰富的资源将继续支持阿基的跨学科临床研究， 促进我们对人类阿基的自然史和病理生理学的理解。我们有信心 核心A与UAB和UCSD的现有资源以及奥布莱恩中心内的其他核心相结合 将加速转化新的研究见解，以改善阿基患者的结局。