Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular disease

为青少年和年轻人身体活动和久坐行为预防心血管疾病提供国家指南

• 批准号: 10471308
• 负责人: Jason M Nagata
• 金额: $ 17.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10471308
• 关键词: Accounting; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Age; American; Area; Behavior; Biometry; Brain; COVID-19 pandemic; Cardiovascular Diseases; Cause of Death; Cessation of life; Clinical Trials; Coronary Artery Risk Development in Young Adults Study; Data; Data Science; Development; Development Plans; Diabetes Mellitus; Dose; Early Intervention; Elderly; Epidemiologist; Event; Exposure to; Future; Grant; Growth and Development function; Guidelines; Health; Health Benefit; Heart Diseases; Human; Hyperlipidemia; Hypertension; Incidence; Intervention; Knowledge; Life; Link; Longitudinal Studies; Longitudinal cohort; Measurement; Medicine; Mentors; Mentorship; Methods; Modeling; Modification; Myocardial Infarction; National Heart, Lung, and Blood Institute; Pattern; Physical activity; Physicians; Population; Premature Mortality; Prevention; Public Health; Recommendation; Research Priority; Resource Allocation; Rest; Risk; Risk Factors; Services; Specific qualifier value; Strategic vision; Stroke; Testing; Text Messaging; Time; Training; United States; United States Dept. of Health and Human Services; Video Games; Visual impairment; age group; base; cardiovascular disorder epidemiology; cardiovascular disorder risk; career; career development; cognitive development; cohort; evidence base; experience; implementation science; longitudinal analysis; markov model; meetings; mortality; physical inactivity; prevent; sedentary; sedentary lifestyle; skills; social media; symposium; tv watching; video chat; young adult

PROJECT SUMMARY / ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in the United States and physical activity is a potent way to decrease this risk. Serious gaps remain in our understanding of the optimal duration of physical activity and sedentary behavior during adolescence and young adulthood if risk for concurrent and future CVD is to be averted, and were specifically identified as priority research areas in the 2018 Department of Health and Human Services (HHS) Physical Activity Guidelines for Americans. Adolescence and young adulthood are critical transition periods that set physical activity patterns for the rest of adulthood and may represent a critical window for early intervention. The overall objective of this K08 is to develop evidence to bridge the HHS-articulated gaps by describing independent effects of sedentary behavior in adolescence and thresholds of physical activity in young adulthood on the prevention of later-life CVD to inform future HHS guidelines. The central hypothesis is that highly sedentary adolescents and young adults will require higher physical activity levels to reduce CVD risk in later adulthood. This project will analyze longitudinal cohort data from the Adolescent Brain Cognitive Development (ABCD) Study, the National Longitudinal Study of Adolescent to Adult Health (Add Health), and the Coronary Artery Risk Development in Young Adults (CARDIA) Study. The Specific Aims will: (1) determine independent associations of contemporary forms of sedentary behavior (screen time) in adolescents with CVD risk factor incidence; (2) evaluate associations of attaining HHS-recommended adolescent (60 mins/day, 7 days/week) versus adult (30 mins/day, 5 days/week) physical activity levels during specific age ranges in young adulthood with incidence of CVD risk factors; and (3) estimate population-level lifetime effects of adolescent and young adult sedentary behaviors, physical activity dose, and their interactions on later-life CVD mortality. The candidate’s long-term career objective is to become an independent physician-epidemiologist generating actionable evidence to optimize adolescent and young adult behaviors to prevent CVD later in life. The proposed career development plan will provide training and mentorship in: (1) physical activity, sedentary behavior, and CVD epidemiology and measurement; (2) longitudinal analyses and modeling methods; (3) guideline development and implementation; and (4) career development and plan for independence. Training will be achieved through coursework, seminars, tutorials, conferences, hands-on experience, and active mentoring. The mentoring team includes nationally recognized experts in cardiovascular epidemiology, adolescent and young adult medicine, physical activity/sedentary behavior, biostatistics, guideline development, and implementation science. Completion of this K08 will inform specific guidance for adolescents and young adults in the next edition of the Physical Activity Guidelines for Americans. The K08 will support a future R01 grant using implementation science and modeling approaches to promote attainment of national physical activity guidelines to prevent CVD, aligned with NHLBI’s strategic vision of reducing heart disease through data and implementation science.

项目摘要 /摘要 心血管疾病（CVD）是美国死亡的主要原因，体育活动是一种有效的 降低这种风险的方法。我们对体育活动最佳持续时间的理解仍然存在严重的差距 如果要同时发生和未来的CVD，青少年和成年期间的久坐行为将是 避免并被明确确定为2018年卫生与人类部的优先研究领域 美国人的服务（HHS）体育活动指南。青少年和成年很关键 过渡期设定了成年剩余的身体活动模式，可能代表关键窗口 进行早期干预。该K08的总体目的是建立证据以弥合HHS明确的差距 通过描述青少年久坐行为的独立影响和体育活动的阈值 年轻的成年期预防后期CVD，以告知未来的HHS准则。中心假设是 高度久坐的青少年和年轻人将需要更高的体育锻炼水平来降低CVD风险 在成年后期。该项目将分析青少年脑认知的纵向队列数据 发展（ABCD）研究，《青少年对成人健康（ADD健康）的国家纵向研究》和 年轻人的冠状动脉风险发展（CARDIA）研究。具体目的将：（1）确定 CVD青少年的当代形式久坐行为（屏幕时间）的独立关联 风险因素发生率； （2）评估达到HHS推荐青少年的关联（60分钟/天，7 与成人（30分钟/天，5天/周）在特定年龄范围内的体育活动水平 成年，CVD风险因素发生率； （3）估计青少年和 年轻的成人久坐行为，体育锻炼剂量及其在后期CVD死亡率上的相互作用。这 候选人的长期职业目标是成为一名独立的物理学专家 可行的证据，以优化青少年和年轻的成人行为，以防止CVD以后的生活。提议 职业发展计划将提供培训和心态：（1）体育锻炼，久坐行为以及 CVD流行病学和测量； （2）纵向分析和建模方法； （3）指南 发展和实施； （4）职业发展和独立计划。培训将是 通过课程，半手，教程，会议，实践经验和积极的心理来实现。 指导团队包括国家公认的心血管流行病学专家 成人医学，体育锻炼/久坐行为，生物统计学，指南开发和实施 科学。该K08的完成将在下一版中为青少年和年轻人提供特定的指导 美国人的体育锻炼指南。 K08将使用实施支持未来的R01赠款 科学和建模方法促进获得国家体育锻炼指南以防止CVD， 与NHLBI通过数据和实施科学减少心脏病的战略愿景相符。