Core H: Religious Orders Study Core

摘要-宗教教团研究核心 宗教秩序研究（ROS）核心的总体目标是支持高质量，前沿，研究 阿尔茨海默病的病因、发病机制、诊断、治疗和预防以及相关的 痴呆（AD/ADRD）。ROS核心将支持广泛的研究， 国家适应行动方案的里程碑，包括：1）人口研究; 2）精准医学和健康差距; 3） 疾病机制，生物标志物和诊断。ROS核心，将招募，注册，老年天主教徒， 宗教人士，他们同意每年进行临床评估，抽血和捐献大脑; 2）支持 研究：a）从无认知障碍（NCI）到MCI到痴呆早期阶段的过渡; B） 将风险因素与正常、MCI事件和AD/ADRD事件联系起来; c）进展和后果 运动功能受损;以及3）促进外部资助的研究，符合 2017年NIA战略计划，包括以下研究：a）认识到 B）支持广泛的分子分析，以填补建立所需的大规模人类数据的空白 疾病和健康的预测模型; c）采用新的研究范式，如系统生物学， 创新的人类细胞建模; d）能够快速和广泛地共享数据、疾病模型、标本， 支持开放科学; e）在虚拟和真实的空间中建立多学科翻译团队， （f）发展新的竞争前公私伙伴关系。 ROS Core自1994年以来一直在运行。它支持a）认知老化异质性的研究 和混合脑病理，B）高分子谱，c）采用系统生物学和人类细胞 建模，d）其数据通过RADC Hub，AMP-AD和NIAGADS快速传播，e）采用 全国和地球仪的多学科和跨学科小组，以及f）在公私部门工作的 与AMD-AD及其姊妹研究在竞争前空间建立伙伴关系。不包括财团文件， 已经产生了650多篇同行评审的手稿，这些手稿在该领域具有很大的影响力，其中有4篇 论文的引用次数为1000-1499，3篇为700-999，7篇为500-699。前10篇论文被引用， 平均922次。此外，ROS核心数据和生物标本已与研究者共享， 几乎所有其他国家情报局资助的广告中心，在全国和北美，南美，欧洲， 中东、亚洲和澳大利亚作为资源价值的进一步证据（见总表1-6和 资源共享计划）。ROS核心设定了与临床和拉丁美洲核心协调的标准， 附属研究拉什记忆和老龄化项目和少数民族老龄化研究，并与 芝加哥健康与老龄化项目。

ABSTRACT – RELIGIOUS ORDERS STUDY CORE The overall goal of the Religious Orders Study (ROS) Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease and related dementias (AD/ADRD). The ROS Core will support a wide range of research studies that address several NAPA milesstones, including, 1) Population Studies; 2) Precision Medicine & Health Disparities; and 3) Disease Mechanisms, and Biomarkers & Diagnosis. The ROS Core, will 1) recruit, enroll, older Catholic religious men and women, who agree to annual clinical evaluations, blood draw and brain donation; 2) support studies: a) of the transition from no cognitive impairment (NCI) to MCI to the earliest stages of dementia; b) linking risk factors to normality, incident MCI, and incident AD/ADRD; c) of the progression and consequences of impaired motor function; and 3) facilitate externally funded research that aligns with the recommendations of the 2017 NIA strategic plan, including studies that: a) recognize the heterogeneity and multifactorial nature of dementias; b) support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness; c) employ new research paradigms such as systems biology and innovative human cell modeling; d) enable rapid and extensive sharing of data, disease models, specimens, and support open science; e) build multidisciplinary translational teams in virtual and real spaces for these teams to operate; and f) develop new precompetitive public-private partnerships. The ROS Core has been in operation since 1994. It supports studies a) of the heteogenety of cognitive aging and mixed brain pathologies, b) of exensive molecular profiling, c) that employ systems biology and human cell modeling, d) whose data are rapidly disseminated via the RADC Hub, AMP-AD, and NIAGADS, e) that employ multi- and inter-disciplinary teams across the country and across the globe, and f) that work in public-private partnerships in the precompetitive space with AMD-AD and its sister studies. Excluding consortium papers, it has resulted in more than 650 peer-reviewed manuscripts that have been highly impactful on the field with 4 papers having 1000-1499 citations, 3 with 700-999, and 7 with 500-699. The top 10 papers were cited an average of 922 times. Further, ROS Core data and biospecimens have been shared with investigators at nearly all other NIA-funded AD Centers, across the county and north America, south America, Europe, the middle east, Asia and Australia as further evidence of the value of the resource (see Overall Tables 1-6 and Resource Sharing Plan). The ROS Core set the standard for harmonization with the Clinical and Latino Cores, affiliated studies Rush Memory and Aging Project and the Minority Aging Research Study, and with the Chicago Health and Aging Proect.