Core A: Administrative Core

摘要-行政核心 拟议的拉什ADRC的总体目标是创造一个跨学科的环境，支持 阿尔茨海默病病因、发病机制、诊断、治疗和预防创新研究 和相关痴呆（AD/ADRD）行政核心将行使全面的科学领导权 设定Rush ADRC的总体方向，确保Rush ADRC的最佳利用 促进《发展与复兴》国家适应行动方案里程碑的执行，并作为其他 国家和地方一级的老龄化和AD/ADRD活动。它将1）确保每个其他核心， 学员通过建立有效的沟通和互动来实现他们的目标和最大的潜力 通过执行委员会; 2）指导ADRC使用机构资源; 3）支持用户- 友好的机制，以促进使用拉什ADRC资源的更广泛的老龄化和AD/ADRD研究 社区，地方，国家和国际，通过资源分配委员会; 4）确定和 支持高质量的开发项目和拉什ADRC研究学者; 5）确保积极和 建设性地参与与其他组织的合作努力，促进研究和了解 AD/ADRD，包括RUMC、NIA ADRC和其他工作; 6）监测成就并修改目标， 通过外部咨询委员会确定未来方向。 这些目标通过精心设计和整合行政核心与其他目标得到支持。 七个核心和研究教育组成部分，包括拉什ADRC。Rush ADRC地址 国家适应行动方案的许多里程碑，包括：1）通过3项社区队列研究和2项 由Rush ADRC研究者进行的R 01资助的附属队列研究，所有研究均与 ROS核心。它们包括多层次、多区域的组学数据，用于精准医疗和健康公平， 队列仅包括黑人和一个拉丁裔，另外两项研究主要是非拉丁裔 白色，2）通过脑深部表型分析的疾病机制，3）转化临床研究-药理学 通过产生用于临床试验的潜在受试者，4）通过神经成像的生物标志物和诊断， 生物流体生物标志物，以及5）通过我们的资源共享中心启用基础设施， https://www.radc.rush.edu/.

ABSTRACT – ADMINISTRATIVE CORE The overall goal of the proposed Rush ADRC is to create an inter-disciplinary environment that supports innovative research on etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s dementia and related dementias (AD/ADRD). The Administrative (Admin) Core will exercise overall scientific leadership of the Rush ADRC to set the overall direction of the Rush ADRC, ensure optimal utilization of Rush ADRC resources, promote the implementation of the ADRD NAPA milestones, and serve as a resource for other aging and AD/ADRD activities at the national and local level. It will 1) ensure that each of the other Cores, and trainees reach their goals and greatest potential by establishing effective communication and interaction through the Executive Committee; 2) guide the use of institutional resources for the ADRC; 3) support a user- friendly mechanism to facilitate the use of Rush ADRC resources by the wider aging and AD/ADRD research community, locally, nationally, and internationally, through the Resource Distribution Committee; 4) identify and support high quality development projects and Rush ADRC Research Scholars; 5) ensure active and constructive participation in collaborative efforts with other organizations, advance research and knowledge of AD/ADRD, including RUMC, NIA ADRCs and other efforts; 6) monitor achievements and modify goals and future directions through the External Advisory Committee. These aims are supported through the careful design and integration of the Administrative Core with the other seven Cores and Research Education Component that comprise the Rush ADRC. The Rush ADRC addresses many of the NAPA Milestones including: 1) population studies via 3 community-based cohort studies and two affiliated cohort studies funded as R01s conducted by Rush ADRC investigators that are all harmonized to the ROS Core. They include multi-level, multi-region omic data for precision medicine and health equity as two cohorts are exclusively of Blacks and one of Latino and the two other studies are predominantly non-Latino white, 2) disease mechanisms via deep brain phenotyping, 3) translational clinical research – pharmacological through the generation of potential subjects for clinical trials, 4) biomarkers & diagnosis via neuroimaging and biofluid biomarkers, and 5) enabling infrastructure via our Resource Sharing Hub at https://www.radc.rush.edu/.