Core H: Religious Orders Study Core

核心 H：宗教秩序研究核心

• 批准号: 10264500
• 负责人: DAVID ALAN BENNETT
• 金额: $ 70.65万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264500
• 关键词: Address; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Australia; Autopsy; Biological; Biological Markers; Blood; Brain; Brain Pathology; Cell model; Chicago; Clinical; Clinical Data; Cognitive aging; Collaborations; Communities; Country; County; Data; Data Collection; Dementia; Diagnosis; Disease; Disease model; Enrollment; Ensure; Etiology; Europe; Far East; Funding; Goals; Health; Heterogeneity; Human; Impaired cognition; Infrastructure; Latino; Link; Magnetic Resonance Imaging; Manuscripts; Memory; Methods; Middle East; Minority; Molecular Profiling; Nature; Normalcy; North America; Online Systems; Paper; Pathogenesis; Peer Review; Persons; Population Study; Precision Health; Process; Recommendation; Religion and Spirituality; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Factors; Sister; South America; Specimen; Strategic Planning; Structure; Systems Biology; Time; Woman; Work; data management; data sharing; design; follow-up; health disparity; human data; improved; in vivo; innovation; men; motor impairment; multidisciplinary; neuroimaging; neuropathology; open data; operation; outreach; precision medicine; predictive modeling; public-private partnership; recruit; religious order study; research clinical testing; research study; tool; virtual

ABSTRACT – RELIGIOUS ORDERS STUDY CORE The overall goal of the Religious Orders Study (ROS) Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease and related dementias (AD/ADRD). The ROS Core will support a wide range of research studies that address several NAPA milesstones, including, 1) Population Studies; 2) Precision Medicine & Health Disparities; and 3) Disease Mechanisms, and Biomarkers & Diagnosis. The ROS Core, will 1) recruit, enroll, older Catholic religious men and women, who agree to annual clinical evaluations, blood draw and brain donation; 2) support studies: a) of the transition from no cognitive impairment (NCI) to MCI to the earliest stages of dementia; b) linking risk factors to normality, incident MCI, and incident AD/ADRD; c) of the progression and consequences of impaired motor function; and 3) facilitate externally funded research that aligns with the recommendations of the 2017 NIA strategic plan, including studies that: a) recognize the heterogeneity and multifactorial nature of dementias; b) support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness; c) employ new research paradigms such as systems biology and innovative human cell modeling; d) enable rapid and extensive sharing of data, disease models, specimens, and support open science; e) build multidisciplinary translational teams in virtual and real spaces for these teams to operate; and f) develop new precompetitive public-private partnerships. The ROS Core has been in operation since 1994. It supports studies a) of the heteogenety of cognitive aging and mixed brain pathologies, b) of exensive molecular profiling, c) that employ systems biology and human cell modeling, d) whose data are rapidly disseminated via the RADC Hub, AMP-AD, and NIAGADS, e) that employ multi- and inter-disciplinary teams across the country and across the globe, and f) that work in public-private partnerships in the precompetitive space with AMD-AD and its sister studies. Excluding consortium papers, it has resulted in more than 650 peer-reviewed manuscripts that have been highly impactful on the field with 4 papers having 1000-1499 citations, 3 with 700-999, and 7 with 500-699. The top 10 papers were cited an average of 922 times. Further, ROS Core data and biospecimens have been shared with investigators at nearly all other NIA-funded AD Centers, across the county and north America, south America, Europe, the middle east, Asia and Australia as further evidence of the value of the resource (see Overall Tables 1-6 and Resource Sharing Plan). The ROS Core set the standard for harmonization with the Clinical and Latino Cores, affiliated studies Rush Memory and Aging Project and the Minority Aging Research Study, and with the Chicago Health and Aging Proect.

摘要 – 宗教秩序研究核心 宗教秩序研究 (ROS) 核心的总体目标是支持高质量、前沿的研究 阿尔茨海默病及相关疾病的病因、发病机制、诊断、治疗和预防项目 痴呆症（AD/ADRD）。 ROS 核心将支持广泛的研究，解决多个问题 NAPA 里程碑，包括：1) 人口研究； 2) 精准医疗与健康差异；和 3) 疾病机制、生物标志物和诊断。 ROS 核心，将 1) 招募、招收老年天主教徒 同意每年进行临床评估、抽血和脑捐赠的宗教人士； 2）支持 研究：a) 从无认知障碍 (NCI) 到 MCI 的转变以及痴呆的最早阶段； b) 将风险因素与常态、事件 MCI 和事件 AD/ADRD 联系起来； c) 进展和后果 运动功能受损； 3) 促进符合以下建议的外部资助研究 2017 年 NIA 战略计划，包括以下研究： a) 认识到的异质性和多因素性质 痴呆症； b) 支持广泛的分子分析，以填补构建所需的大规模人类数据的空白 疾病和健康的预测模型； c）采用新的研究范式，例如系统生物学和 创新的人体细胞模型； d) 实现数据、疾病模型、标本的快速和广泛共享， 并支持开放科学； e) 在虚拟和现实空间中为这些建立多学科翻译团队 团队运作； f) 发展新的竞争前公私伙伴关系。 ROS 核心自 1994 年以来一直在运行。它支持 a) 认知衰老异质性的研究 和混合脑病理学，b）广泛的分子分析，c）采用系统生物学和人类细胞 建模，d) 其数据通过 RADC Hub、AMP-AD 和 NIAGADS 快速传播，e) 采用 遍布全国和全球的多学科和跨学科团队，以及 f) 在公私部门开展工作 与 AMD-AD 及其姐妹研究在竞争前领域建立伙伴关系。不包括财团文件， 已产生超过 650 份经过同行评审的手稿，这些手稿在该领域具有高度影响力，其中 4 被引用次数为 1000-1499 次的论文，700-999 次引用的论文 3 篇，500-699 次引用的论文 7 篇。被引用次数排名前 10 的论文 平均922次。此外，ROS 核心数据和生物样本已与研究人员共享 几乎所有其他 NIA 资助的 AD 中心，遍布全县以及北美、南美、欧洲、 中东、亚洲和澳大利亚作为资源价值的进一步证据（见总表 1-6 和 资源共享计划）。 ROS 核心设定了与临床和拉丁核心协调的标准， 附属研究“拉什记忆与衰老项目”和“少数民族衰老研究”，并与 芝加哥健康与老龄化项目。