Core H: Religious Orders Study Core

核心 H：宗教秩序研究核心

• 批准号: 10264500
• 负责人: DAVID ALAN BENNETT
• 金额: $ 70.65万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264500
• 关键词: Address; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Australia; Autopsy; Biological; Biological Markers; Blood; Brain; Brain Pathology; Cell model; Chicago; Clinical; Clinical Data; Cognitive aging; Collaborations; Communities; Country; County; Data; Data Collection; Dementia; Diagnosis; Disease; Disease model; Enrollment; Ensure; Etiology; Europe; Far East; Funding; Goals; Health; Heterogeneity; Human; Impaired cognition; Infrastructure; Latino; Link; Magnetic Resonance Imaging; Manuscripts; Memory; Methods; Middle East; Minority; Molecular Profiling; Nature; Normalcy; North America; Online Systems; Paper; Pathogenesis; Peer Review; Persons; Population Study; Precision Health; Process; Recommendation; Religion and Spirituality; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Factors; Sister; South America; Specimen; Strategic Planning; Structure; Systems Biology; Time; Woman; Work; data management; data sharing; design; follow-up; health disparity; human data; improved; in vivo; innovation; men; motor impairment; multidisciplinary; neuroimaging; neuropathology; open data; operation; outreach; precision medicine; predictive modeling; public-private partnership; recruit; religious order study; research clinical testing; research study; tool; virtual

ABSTRACT – RELIGIOUS ORDERS STUDY CORE The overall goal of the Religious Orders Study (ROS) Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease and related dementias (AD/ADRD). The ROS Core will support a wide range of research studies that address several NAPA milesstones, including, 1) Population Studies; 2) Precision Medicine & Health Disparities; and 3) Disease Mechanisms, and Biomarkers & Diagnosis. The ROS Core, will 1) recruit, enroll, older Catholic religious men and women, who agree to annual clinical evaluations, blood draw and brain donation; 2) support studies: a) of the transition from no cognitive impairment (NCI) to MCI to the earliest stages of dementia; b) linking risk factors to normality, incident MCI, and incident AD/ADRD; c) of the progression and consequences of impaired motor function; and 3) facilitate externally funded research that aligns with the recommendations of the 2017 NIA strategic plan, including studies that: a) recognize the heterogeneity and multifactorial nature of dementias; b) support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness; c) employ new research paradigms such as systems biology and innovative human cell modeling; d) enable rapid and extensive sharing of data, disease models, specimens, and support open science; e) build multidisciplinary translational teams in virtual and real spaces for these teams to operate; and f) develop new precompetitive public-private partnerships. The ROS Core has been in operation since 1994. It supports studies a) of the heteogenety of cognitive aging and mixed brain pathologies, b) of exensive molecular profiling, c) that employ systems biology and human cell modeling, d) whose data are rapidly disseminated via the RADC Hub, AMP-AD, and NIAGADS, e) that employ multi- and inter-disciplinary teams across the country and across the globe, and f) that work in public-private partnerships in the precompetitive space with AMD-AD and its sister studies. Excluding consortium papers, it has resulted in more than 650 peer-reviewed manuscripts that have been highly impactful on the field with 4 papers having 1000-1499 citations, 3 with 700-999, and 7 with 500-699. The top 10 papers were cited an average of 922 times. Further, ROS Core data and biospecimens have been shared with investigators at nearly all other NIA-funded AD Centers, across the county and north America, south America, Europe, the middle east, Asia and Australia as further evidence of the value of the resource (see Overall Tables 1-6 and Resource Sharing Plan). The ROS Core set the standard for harmonization with the Clinical and Latino Cores, affiliated studies Rush Memory and Aging Project and the Minority Aging Research Study, and with the Chicago Health and Aging Proect.

摘要-教团研究的核心