Core A: Administrative Core

核心A：行政核心

• 批准号: 10264494
• 负责人: DAVID ALAN BENNETT
• 金额: $ 26.61万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264494
• 关键词: Academic Medical Centers; Achievement; Address; Administrator; Advisory Committees; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease therapeutic; Biological Markers; Brain; Clinical Research; Clinical Trials; Cohort Studies; Collaborations; Communication; Communities; Data; Dementia; Development; Diagnosis; Disease; Ensure; Etiology; Exercise; Faculty; Family Study; Funding; Funding Mechanisms; Future; Generations; Genetic Diseases; Goals; Infrastructure; Institution; International; Investments; Knowledge; Latino; Leadership; Monitor; NCI Scholars Program; National Institute on Aging; Pathogenesis; Pharmacology; Phenotype; Population Study; Precision Health; Reporting; Research; Research Institute; Research Personnel; Resource Sharing; Resources; Review Committee; base; cohort; collaborative environment; data hub; design; education research; health equity; innovation; meetings; neuroimaging; new therapeutic target; precision medicine; summer internship; user-friendly

ABSTRACT – ADMINISTRATIVE CORE The overall goal of the proposed Rush ADRC is to create an inter-disciplinary environment that supports innovative research on etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s dementia and related dementias (AD/ADRD). The Administrative (Admin) Core will exercise overall scientific leadership of the Rush ADRC to set the overall direction of the Rush ADRC, ensure optimal utilization of Rush ADRC resources, promote the implementation of the ADRD NAPA milestones, and serve as a resource for other aging and AD/ADRD activities at the national and local level. It will 1) ensure that each of the other Cores, and trainees reach their goals and greatest potential by establishing effective communication and interaction through the Executive Committee; 2) guide the use of institutional resources for the ADRC; 3) support a user- friendly mechanism to facilitate the use of Rush ADRC resources by the wider aging and AD/ADRD research community, locally, nationally, and internationally, through the Resource Distribution Committee; 4) identify and support high quality development projects and Rush ADRC Research Scholars; 5) ensure active and constructive participation in collaborative efforts with other organizations, advance research and knowledge of AD/ADRD, including RUMC, NIA ADRCs and other efforts; 6) monitor achievements and modify goals and future directions through the External Advisory Committee. These aims are supported through the careful design and integration of the Administrative Core with the other seven Cores and Research Education Component that comprise the Rush ADRC. The Rush ADRC addresses many of the NAPA Milestones including: 1) population studies via 3 community-based cohort studies and two affiliated cohort studies funded as R01s conducted by Rush ADRC investigators that are all harmonized to the ROS Core. They include multi-level, multi-region omic data for precision medicine and health equity as two cohorts are exclusively of Blacks and one of Latino and the two other studies are predominantly non-Latino white, 2) disease mechanisms via deep brain phenotyping, 3) translational clinical research – pharmacological through the generation of potential subjects for clinical trials, 4) biomarkers & diagnosis via neuroimaging and biofluid biomarkers, and 5) enabling infrastructure via our Resource Sharing Hub at https://www.radc.rush.edu/.

抽象行政核心 拟议的Rush ADRC的总体目标是创造一个跨学科的环境，以支持 阿尔茨海默病的病因、发病机制、诊断、治疗和预防的创新研究 和相关痴呆症(AD/ADRD)。行政(行政)核心将实行全面科学领导 确定Rush ADRC的总体方向，确保Rush ADRC的最佳利用 资源，促进落实亚洲复兴开发银行国家适应行动方案里程碑，并作为其他方面的资源 国家和地方两级的老龄化和AD/ADRD活动。它将1)确保每个其他核心，以及 学员通过建立有效的沟通和互动达到他们的目标和最大潜力 通过执行委员会；2)指导ADRC使用机构资源；3)支持用户-- 促进更广泛的老龄化和AD/ADRD研究使用Rush ADRC资源的友好机制 社区、地方、国家和国际，通过资源分配委员会；4)确定和 支持高质量发展项目和Rush ADRC研究学者；5)确保积极和 建设性地参与与其他组织的合作努力，促进研究和了解 AD/ADRD，包括RUMC、NIA ADRC和其他努力；6)监测成就并修改目标和 通过外部咨询委员会确定未来方向。 这些目标通过行政核心与其他行政核心的精心设计和整合而得到支持 组成Rush ADRC的七个核心和研究教育部分。Rush ADRC发表演讲 国家适应行动方案的许多里程碑包括：1)通过3项以社区为基础的队列研究和2项 由Rush ADRC调查人员作为R01资助的附属队列研究，均与 罗斯·科尔。它们包括精准医疗和健康公平的多层次、多地区的经济数据 队列中只有黑人和一名拉丁裔，另外两项研究主要是非拉丁裔 怀特，2)脑深部表型的疾病机制，3)转译临床研究-药理学 通过产生潜在的临床试验受试者，4)生物标志物和通过神经成像和诊断 生物流体生物标志物，以及5)通过我们的资源共享中心实现基础设施 Https://www.radc.rush.edu/.