Respiratory Sinus Arrhythmia as a Predictor of Substance Use among Early Adolescents

呼吸性窦性心律失常是青少年早期药物滥用的预测因素

• 批准号: 10473665
• 负责人: Wendy S Hadley
• 金额: $ 69.28万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10473665
• 关键词: Address; Adolescence; Adolescent; Adolescent Risk Behavior; Age; Alcohol consumption; Behavioral; Breathing; Classification; Collection; Computers; Data; Early identification; Emotional; Emotions; Environment; Event; Exhibits; Exposure to; Frequencies; HIV-2; Health; Healthy People 2020; Hormones; Intervention; Laboratories; Literature; Measurement; Measures; Mental Health; Modeling; Outcome; Parasympathetic Nervous System; Parents; Participant; Patient Self-Report; Pattern; Pilot Projects; Play; Prevention; Process; Race; Recording of previous events; Recovery; Regulation; Reporting; Research; Resources; Rest; Risk; Risk Behaviors; Risk-Taking; Role; Sampling; Science; Sex Behavior; Sexually Transmitted Diseases; Sinus Arrhythmia; Symptoms; Testing; Time; Youth; adolescent health; adolescent substance use; analog; computerized; early adolescence; early onset substance use; emotion regulation; follow-up; heart rate variability; improved; indexing; innovation; insight; marijuana use; novel; parental monitoring; peer; peer influence; pregnancy prevention; preventive intervention; prospective; respiratory; respiratory challenge; response; risk prediction; sex; sexual risk behavior; sexual risk taking; substance use; tool; virtual reality; virtual reality environment; vulnerable adolescent

Respiratory sinus arrhythmia as a predictor of substance use among early adolescents Risk behaviors that cause negative health outcomes, such as substance use or sexual risk behaviors, typically begin in adolescence. Identifying those most at risk in early adolescence is critical for prevention interventions. Emotion regulation plays an important role in reducing adolescent risk but detecting those who are vulnerable because of deficits in emotion regulation during early adolescence is challenging due to poor adolescent insight into these still-developing emotional processes. Respiratory sinus arrhythmia (RSA), an index of heart rate variability that is influenced by the parasympathetic nervous system, is an established marker of emotion regulation processes. RSA does not rely on self-report and may be useful for early identification of risk. Our team has developed a novel virtual reality party task with which to assess emotion regulation patterns in adolescents. Pilot data in our laboratory using this task suggest that adolescents with a history of substance use exhibit slower return to baseline RSA (measured at rest) after exposure to a challenging situation (referred to as recovery RSA) compared to non-using peers. This may suggest that recovery RSA is a relevant index of emotion regulation related to risk behaviors, as emotional triggers often occur in rapid succession in real-world risk situations. The proposed study will prospectively examine RSA's utility in predicting adolescent risk behaviors (substance use and sexual risk) among a sample of 280 early adolescents (ages 12.0-12.5 years) for a period of 24 months. We will also evaluate whether emotion regulation in the context of a substance use and sexual risk-taking situation (the virtual reality party) is more useful in predicting risk behavior than a computer risk-taking task (the Balloon Analogue Risk Task). We also will examine strategies for defining recovery RSA, given inconsistencies in the current literature. The current proposal advances the field by combining virtual reality and RSA collection to assess emotion regulation with the aim of identifying markers of those most vulnerable to engaging in risk behaviors at an early age, thus innovating the science of prevention.

呼吸窦性心律失常作为早期青少年物质使用的预测指标 导致负面健康结果的风险行为，例如使用物质或性风险行为，通常是 从青春期开始。在青春期早期确定最有风险的人对于预防干预至关重要。 情绪监管在降低青少年风险中起着重要的作用，但发现那些脆弱的人 由于青春期差，青春期早期的情绪调节缺陷是具有挑战性的 深入了解这些仍在发展的情感过程。呼吸窦性心律失常（RSA），心脏索引 受副交感神经系统影响的速率变异性是情绪的既定标志 调节过程。 RSA不依赖自我报告，可能对早期识别风险有用。我们的 团队已经开发了一项新颖的虚拟现实党任务，以评估情绪调节模式 青少年。我们实验室中使用此任务的飞行员数据表明​​，具有物质史的青少年 暴露于挑战性情况后，使用展览较慢回到基线RSA（在休息时测量）（引用 与非使用同行相比，为恢复RSA）。这可能表明恢复RSA是 情绪调节与风险行为有关，因为情绪触发器经常在现实世界中迅速出现 风险情况。拟议的研究将前瞻性地检查RSA在预测青少年风险方面的效用 280名早期青少年样本（12.0-12.5岁）中的行为（使用和性风险） 长达24个月。我们还将评估是否在使用物质的背景下进行情绪调节 性冒险状况（虚拟现实党）在预测风险行为方面比 计算机冒险任务（气球模拟风险任务）。我们还将研究定义的策略 恢复RSA，鉴于当前文献中的不一致。当前的提议通过 结合虚拟现实和RSA收集以评估情绪调节的目的 那些最容易在童年时期从事风险行为的人，从而创新了预防科学。