2022 Angiotensin GRC/GRS

2022 血管紧张素 GRC/GRS

• 批准号: 10381797
• 负责人: Minolfa C Prieto
• 金额: $ 4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-23 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381797
• 关键词: 2019-nCoV; ACE2; Academia; Address; Adipose tissue; Aging; Angiotensin I; Angiotensin II; Angiotensin Receptor; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Anniversary; Area; Award; Basic Science; Biology; Blood Pressure; Bone Marrow; COVID-19; COVID-19 pandemic; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Clinic; Clinical; Clinical Medicine; Clinical Sciences; Collaborations; Data; Development; Diabetes Mellitus; Digestive System Disorders; Disease; Doctor of Medicine; Doctor of Philosophy; Electrolyte Balance; Electrolytes; Endocrine System Diseases; Enzymes; Etiology; Event; Fostering; Funding; Future; Gender; Generations; Goals; Health; Health Sciences; Hematological Disease; Homeostasis; Human Biology; Hypertension; Immune response; Immune system; Industry; Inflammatory Response; Institutes; International; Joints; Kidney; Kidney Diseases; Lead; Leadership; Life Cycle Stages; Liquid substance; Mediator of activation protein; Medical Research; Mentors; Mentorship; Metabolic Diseases; Minority Groups; Mission; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Disease; National Institute of Diabetes and Digestive and Kidney Diseases; Neurocognition; Neurosecretory Systems; Nutrition Disorders; Obesity; Organ; Outcome; Oxidative Stress; Pathologic Processes; Pathology; Persons; Pharmacogenomics; Population; Postdoctoral Fellow; Productivity; Proteins; Proteomics; Public Health; Quality of life; Regulation; Renin-Angiotensin-Aldosterone System; Research; Research Personnel; Research Training; Role; SARS-CoV-2 infection; Science; Scientist; Sex Differences; System; Therapeutic; Tissues; Translating; Translational Research; Travel; Underrepresented Minority; Underrepresented Populations; United Kingdom; United States National Institutes of Health; Universities; Urologic Diseases; Virginia; Woman; Women Physicians; angiotensin I (1-7); arm; base; career; career development; design; fetal programming; frontier; graduate student; human disease; improved; insight; liver function; meetings; metabolomics; minority student; nephrogenesis; novel; precision medicine; programs; receptor; receptor function; success; symposium; systems research; therapeutic target; tool; undergraduate student

PROJECT SUMMARY The renin angiotensin aldosterone system (RAAS) is a key regulator of cardiovascular (CV) function, fluid electrolyte balance, and homeostasis, and it influences many systems including the renal, neuroendocrine, and immune systems. Perturbations of the RAAS trigger a cascade of events, including generation of vasoactive mediators, oxidative stress, inflammatory responses, and tissue remodeling, thus contributing to end-organ pathology and disease. In the 2022 GRC on Ang, we will discuss the most recent, cutting-edge discoveries in the field and share insights on emerging new areas beyond the CV system such as the role of the RAAS in adipose biology, bone marrow regulation, liver function, neurocognition, and immune responses. The conference will focus on the latest advances of the RAAS from discovery science to clinical impact. A highlight in 2022 will be the celebration of 22 years of the discovery of ACE2. ACE2 is a multifunctional protein, that not only is CV protective by generating Ang-(1-7) and Ang-(1-9) from Ang II and Ang I respectively, but it is also, tissue injurious by acting as the receptor for the SARS-CoV-2, the etiologic agent of the current worldwide COVID-19 pandemic. The enigmas of ACE2 as a key enzyme in the protective arm of the RAAS will be a highlight. The role of ACE2 as a major mediator and potential therapeutic target in COVID-19 will be debated along with the controversies on the progression of COVID-19 infection and long-term outcomes in populations treated with ACE inhibitors and/or angiotensin receptor blockers. The 2022 GRC on Ang will further feature novel topics including sex-differences in the regulation and changes of the RAAS during the life course (fetal programming, kidney development, and aging) will be further addressed. In line with precision medicine being the next frontier in clinical medicine, the meeting will also highlight new advances in the pharmacogenomics, proteomics, and metabolomics of the RAAS in human diseases. Preceding the GRC, we will have the 2022 Gordon Research Seminar (GRS), a special forum for graduate students, postdoctoral fellows, early career researchers and other junior scientists to present and exchange new data and cutting-edge ideas. The 2022 GRS will focus on recent advances in RAAS studies beyond the classical paradigms, including new functions of receptors from this system and providing trainees with an enhanced understanding of current tools to aid their research, and cover a wide range of topics including the immune system, sex differences and aging. Additionally, the mentorship sessions will address the interplay between academia and industry and discuss approaches to translate scientific discoveries to the clinic and how to optimize impact. The aims are aligned with the NHLBI, NIDDK and NIAID missions and initiative and the scientific themes that will be covered are of direct relevance to these institutes. NIH funds requested will help attract young investigators and trainees, including from underrepresented groups with limited opportunities to joint top national and international experts in the RAAS for networking among researchers, clinicians, young investigators and trainees.

项目总结 肾素-血管紧张素-醛固酮系统(RAAS)是心血管功能的重要调节因子。 电解质平衡和动态平衡，它影响许多系统，包括肾脏、神经内分泌和 免疫系统。RAS的扰动触发了一系列事件，包括血管活性的产生 中介物、氧化应激、炎症反应和组织重塑，从而促进终末器官 病理学和疾病。在2022年关于ANG的GRC中，我们将讨论最新的前沿发现 现场并分享对简历系统以外的新兴新领域的见解，例如RAAS在 脂肪生物学、骨髓调节、肝功能、神经认知和免疫反应。这个 会议将集中讨论RAAS从发现科学到临床影响的最新进展。一大亮点 2022年将是ACE2发现22周年的庆典。ACE2是一种多功能蛋白质，而不是 仅通过分别从Ang II和Ang I生成Ang-(1-7)和Ang-(1-9)来保护CV，但它也是， 作为SARS-CoV-2的受体对组织造成损害，SARS-CoV-2是目前全球范围内的病原体 新冠肺炎大流行。ACE2作为RAAS保护臂中的关键酶的谜团将是一个 重点。血管紧张素转换酶2在新冠肺炎中作为一个主要的介质和潜在的治疗靶点的作用将会被争论。 伴随着关于新冠肺炎感染的进展和人群长期结局的争议 用血管紧张素转换酶抑制剂和/或血管紧张素受体阻滞剂治疗。Ang上的2022年GRC将进一步 新颖的主题，包括生命过程中RAAS调节和变化的性别差异(胎儿 规划、肾脏发育和老龄化)将进一步得到解决。与精准医疗相一致 临床医学的下一个前沿，会议还将突出药物基因组学的新进展， 蛋白质组学和人类疾病中RAAS的代谢组学。在GRC之前，我们将有2022年 戈登研究研讨会(GRS)，一个专门为研究生、博士后研究员、早期职业生涯举办的论坛 研究人员和其他初级科学家展示和交流新数据和前沿思想。2022年 GRS将关注RAAS研究的最新进展，超越经典范式，包括新功能 了解该系统的受体，并为受训者提供对当前辅助工具的增强理解 他们的研究涵盖了广泛的主题，包括免疫系统、性别差异和衰老。 此外，导师会议将讨论学术界和工业界之间的相互作用，并讨论 将科学发现转化为临床的方法以及如何优化影响。目标是一致的 随着NHLBI、NIDDK和NIAID的任务和倡议以及将涵盖的科学主题 与这些机构直接相关。NIH申请的资金将有助于吸引年轻的研究人员和实习生， 包括从代表性不足、机会有限的群体到联合顶级国家和国际专家 在研究人员、临床医生、年轻研究人员和受训人员之间建立网络的RAAS。