Long-Term Alcohol Use Effects of a Training Intervention for ADHD

多动症训练干预的长期饮酒效果

• 批准号: 10382254
• 负责人: Samantha Margherio
• 金额: $ 1.2万
• 依托单位: OHIO UNIVERSITY ATHENS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10382254
• 关键词: Address; Adolescence; Adolescent; Aftercare; Age; Alcohol abuse; Alcohol consumption; Alcoholic Intoxication; Area; Attention deficit hyperactivity disorder; Behavior; Behavioral; Biological; Caring; Cause of Death; Collection; Communities; Complex; Consultations; Data; Development; Education; Educational Intervention; Educational workshop; Equation; Evaluation Research; Fatal Outcome; Fellowship; Female; Future; Goals; Individual; Injury; Institutes; Intervention; Investigation; Link; Long-Term Effects; Longterm Follow-up; Measures; Methods; Modality; Modeling; Outcome; Paper; Participant; Pathway interactions; Patient Self-Report; Pattern; Pharmaceutical Preparations; Physiological; Physiology; Population; Populations at Risk; Prevention; Problem Solving; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Risk; Risk Factors; Role; Rotation; Sampling; Science; Sex Differentiation; Study Skills; Symptoms; Time; Training; Work; Youth; adverse outcome; aged; alcohol related problem; alcohol risk; alcohol use disorder; biopsychosocial; career; design; diagnostic criteria; emerging adult; emerging adulthood; emotion dysregulation; experience; follow-up; high school; intervention effect; intervention program; male; peer; recruit; research and development; self reported behavior; sex; skills; substance use; theories; therapy development; underage drinking; young adult

Project Summary/Abstract The long-term objective of the proposed study is to identify a putative intervention mechanism of change for altering the developmental trajectory of alcohol use problems among an at-risk population. To attain this goal, the applicant will receive advanced training in risk factors of alcohol use, multi-method data design and collection, and quantitative skills via coursework, lab rotations, workshops, and consultation. This is an important area of research as adolescents with ADHD are at-risk for experiencing alcohol-related problems 5,6 and developing alcohol use disorders as emerging adults 3, 4. The applicant’s team previously implemented a training intervention for adolescents with ADHD, and preliminary investigations revealed this intervention was the first intervention for youth with ADHD to be associated with positive treatment-related gains in alcohol use problems 7. The magnitude of these differences grew over time, consistent with findings of other outcomes from this intervention 14. Thus, this intervention may alter the developmental trajectory of alcohol use problems for adolescents with ADHD. A leading developmental biopsychosocial model of the link between ADHD and alcohol use problems 10 highlights the critical role of emotion dysregulation (ED) in catalyzing risk for alcohol use problems among individuals with ADHD. Thus, the goals of the current study are to examine the durability of improvements in alcohol-related problems as the youth transition into emerging adulthood, a time when alcohol use peaks 2, and to examine ED as a putative mechanism of change in the pathway to problematic alcohol use. Efforts will be made to retain the original sample of adolescents with ADHD (n = 171) who previously participated in a randomized controlled trial of a training intervention while in high school. Participants provided self-report of alcohol use behaviors and ED at 3 points over the previous 3 to 5 years. In the proposed study, participants will report their current patterns of alcohol use and associated problems. To enhance our understanding of the complex construct of ED, ED will be measured via multiple units of analysis (i.e., self-report, physiological, behavior). Structural equation modeling will be employed to address the following aims: (1) examine intervention effects on alcohol use problems; (2) examine intervention effects on ED; and (3) examine the association between ED and alcohol use problems, and, in an exploratory aim, examine whether intervention has an effect on alcohol use problems via ED. Sex will be explored as a moderator across these aims given evidence of potential sex-specific pathways to use among individuals with ADHD 55-58. The proposed study has the potential to identify an intervention mechanism of change to be targeted in future interventions that may reduce the detrimental outcomes experienced by youth at-risk of alcohol use problems. Further, the training afforded to the applicant through this fellowship will enhance her ability to conduct basic and mechanistic research necessary for a career as an independent researcher capable of conducting intervention development and evaluation research for at-risk youth.

项目摘要/摘要 拟议研究的长期目标是确定一种推定的干预机制 改变高危人群中酒精使用问题的发展轨迹的变化。达到 这个目标，申请人将接受饮酒风险因素，多方法数据设计的高级培训 通过课程，实验室轮换，研讨会和咨询，收集和定量技能。这是一个 作为ADHD的青少年，重要的研究领域因遇到酒精有关的问题而处于危险中5,6 并发展为新兴的成年人3，4。申请人团队以前实施了 为患有多动症的青少年和初步调查的培训干预措施表明，这种干预措施是 ADHD青年的首次干预与饮酒相关的积极相关收益有关 问题7。这些差异的幅度随着时间的推移而增长，与其他结果的发现一致 这项干预14。那就是，这种干预可能会改变酒精使用问题的发展轨迹 患有多动症的青少年。 ADHD和 酒精使用问题10突出了情绪失调（ED）在催化酒精风险中的关键作用 使用多动症患者中的问题。这是当前研究的目标是检查耐用性 随着青年过渡到新兴成年的过渡，与酒精相关问题的改善，这是 酒精使用峰值2，并将ED视为有问题的途径的推定机制 饮酒。将努力保留ADHD（n = 171）的青少年的原始样本 先前在高中时参加了培训干预措施的随机对照试验。 参与者提供了饮酒行为的自我报告，并在过去的3到5年中以3分为单位。在 拟议的研究，参与者将报告他们当前的酒精使用方式和相关问题。到 增强我们对ED，ED复杂结构的理解，将通过多个分析单位进行测量 （即自我报告，生理，行为）。结构方程建模将用于解决 以下目的：（1）检查干预对酒精使用问题的影响； （2）检查干预对 ed; （3）检查ED与酒精使用问题之间的关联，并在探索性目的中 检查干预是否会通过ED对酒精使用问题产生影响。性将被探讨为 这些目标的主持人给出了潜在的性别特异性途径的证据 多动症55-58。拟议的研究有可能确定变化的干预机制为 针对以后的干预措施，可能会减少青年处于危险中的确定结果 酒精使用问题。此外，通过此奖学金向申请人提供的培训将使她增强 具有独立研究人员职业所必需的基本和机械研究的能力 能够为高危青年进行干预开发和评估研究。