Long-Term Alcohol Use Effects of a Training Intervention for ADHD

多动症训练干预的长期饮酒效果

• 批准号: 10382254
• 负责人: Samantha Margherio
• 金额: $ 1.2万
• 依托单位: OHIO UNIVERSITY ATHENS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10382254
• 关键词: Address; Adolescence; Adolescent; Aftercare; Age; Alcohol abuse; Alcohol consumption; Alcoholic Intoxication; Area; Attention deficit hyperactivity disorder; Behavior; Behavioral; Biological; Caring; Cause of Death; Collection; Communities; Complex; Consultations; Data; Development; Education; Educational Intervention; Educational workshop; Equation; Evaluation Research; Fatal Outcome; Fellowship; Female; Future; Goals; Individual; Injury; Institutes; Intervention; Investigation; Link; Long-Term Effects; Longterm Follow-up; Measures; Methods; Modality; Modeling; Outcome; Paper; Participant; Pathway interactions; Patient Self-Report; Pattern; Pharmaceutical Preparations; Physiological; Physiology; Population; Populations at Risk; Prevention; Problem Solving; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Risk; Risk Factors; Role; Rotation; Sampling; Science; Sex Differentiation; Study Skills; Symptoms; Time; Training; Work; Youth; adverse outcome; aged; alcohol related problem; alcohol risk; alcohol use disorder; biopsychosocial; career; design; diagnostic criteria; emerging adult; emerging adulthood; emotion dysregulation; experience; follow-up; high school; intervention effect; intervention program; male; peer; recruit; research and development; self reported behavior; sex; skills; substance use; theories; therapy development; underage drinking; young adult

Project Summary/Abstract The long-term objective of the proposed study is to identify a putative intervention mechanism of change for altering the developmental trajectory of alcohol use problems among an at-risk population. To attain this goal, the applicant will receive advanced training in risk factors of alcohol use, multi-method data design and collection, and quantitative skills via coursework, lab rotations, workshops, and consultation. This is an important area of research as adolescents with ADHD are at-risk for experiencing alcohol-related problems 5,6 and developing alcohol use disorders as emerging adults 3, 4. The applicant’s team previously implemented a training intervention for adolescents with ADHD, and preliminary investigations revealed this intervention was the first intervention for youth with ADHD to be associated with positive treatment-related gains in alcohol use problems 7. The magnitude of these differences grew over time, consistent with findings of other outcomes from this intervention 14. Thus, this intervention may alter the developmental trajectory of alcohol use problems for adolescents with ADHD. A leading developmental biopsychosocial model of the link between ADHD and alcohol use problems 10 highlights the critical role of emotion dysregulation (ED) in catalyzing risk for alcohol use problems among individuals with ADHD. Thus, the goals of the current study are to examine the durability of improvements in alcohol-related problems as the youth transition into emerging adulthood, a time when alcohol use peaks 2, and to examine ED as a putative mechanism of change in the pathway to problematic alcohol use. Efforts will be made to retain the original sample of adolescents with ADHD (n = 171) who previously participated in a randomized controlled trial of a training intervention while in high school. Participants provided self-report of alcohol use behaviors and ED at 3 points over the previous 3 to 5 years. In the proposed study, participants will report their current patterns of alcohol use and associated problems. To enhance our understanding of the complex construct of ED, ED will be measured via multiple units of analysis (i.e., self-report, physiological, behavior). Structural equation modeling will be employed to address the following aims: (1) examine intervention effects on alcohol use problems; (2) examine intervention effects on ED; and (3) examine the association between ED and alcohol use problems, and, in an exploratory aim, examine whether intervention has an effect on alcohol use problems via ED. Sex will be explored as a moderator across these aims given evidence of potential sex-specific pathways to use among individuals with ADHD 55-58. The proposed study has the potential to identify an intervention mechanism of change to be targeted in future interventions that may reduce the detrimental outcomes experienced by youth at-risk of alcohol use problems. Further, the training afforded to the applicant through this fellowship will enhance her ability to conduct basic and mechanistic research necessary for a career as an independent researcher capable of conducting intervention development and evaluation research for at-risk youth.

项目总结/摘要 这项拟议研究的长远目标是确定一个假定的干预机制， 改变风险人群中酒精使用问题的发展轨迹。实现 这一目标，申请人将接受酒精使用的危险因素，多方法数据设计的高级培训 和收集，并通过课程，实验室轮换，研讨会和咨询定量技能。这是一 重要的研究领域，因为患有ADHD的青少年有经历酒精相关问题的风险5，6 和发展酒精使用障碍作为新兴的成年人3，4。申请人的团队以前实施了一项 对患有ADHD的青少年进行培训干预，初步调查显示， 第一次对ADHD青少年的干预与酒精使用的积极治疗相关收益有关 问题7.这些差异的大小随着时间的推移而增加，与其他结果的发现一致。 这次干预14.因此，这种干预可能会改变酒精使用问题的发展轨迹， ADHD青少年一个领先的发展生物心理社会模型之间的联系多动症和 酒精使用问题10强调了情绪失调（艾德）在催化酒精风险中的关键作用 注意力缺陷多动障碍患者的问题。因此，本研究的目的是检查耐久性 随着年轻人进入成年期，与酒精有关的问题有所改善， 酒精使用峰2，并检查艾德作为一个假定的机制的变化途径的问题 饮酒将努力保留ADHD青少年的原始样本（n = 171）， 以前参加了一个随机对照试验的训练干预，而在高中。 参与者提供了自我报告的酒精使用行为和艾德在3点在过去的3至5年。在 在这项拟议的研究中，参与者将报告他们目前的饮酒模式和相关问题。到 为了加深我们对艾德复杂结构的理解，艾德将通过多个分析单元进行测量 (i.e.,自我报告、生理、行为）。结构方程模型将被用来解决 以下目的：（1）研究干预对酒精使用问题的影响;（2）研究干预对酒精使用问题的影响。 艾德;和（3）检查艾德和酒精使用问题之间的关联，并且，在探索性目的中， 通过ED检查干预是否对酒精使用问题有影响。 这些目标的主持人给出了潜在的性别特异性途径在患有 注意力缺陷多动障碍55-58.拟议的研究有可能确定一个干预机制的变化， 在未来的干预措施中有针对性地采取行动，以减少有风险的青年所经历的有害后果。 酒精使用问题。此外，通过该奖学金向申请人提供的培训将提高她的能力。 能够进行作为一个独立的研究人员的职业生涯所必需的基础和机械研究 有能力为问题青年开展干预发展和评估研究。