MRI Measurement of the Mechanical Vulnerability of the Brain
大脑机械损伤的 MRI 测量
基本信息
- 批准号:10474698
- 负责人:
- 金额:$ 4.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-15 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAccelerationAddressAdultAgeAnimalsAnteriorBiomedical EngineeringBrainBrain InjuriesCadaverCharacteristicsChronicChronic Brain InjuryCognitive deficitsCollaborationsComputer ModelsComputer SimulationDataDelawareDevelopmentElderlyEmotional disorderEquipmentFemaleFoundationsFrequenciesGenderHelmetHumanImage AnalysisImpulsivityIndividualInjuryLeftMagnetic Resonance ImagingMeasurementMeasuresMechanicsMemory impairmentMethodsModelingMotionPathologyPatternPhysiologic pulsePopulationPreventionProcessPropertyResearchResearch PersonnelResolutionRotationSex DifferencesShapesSiteSpecimenTestingTissuesTranslationsTraumatic Brain InjuryUniversitiesWashingtonage effectage groupbasechronic traumatic encephalopathycollegecraniumdata toolsdesignelastographyexperiencehead impacthigh schoolimage processingimaging modalityimprovedinnovationmalenext generationnovelpredictive modelingresponsesensorsexsimulationthree-dimensional modelingtoolviscoelasticity
项目摘要
PROJECT ABSTRACT: This Bioengineering Research Partnership (BRP) will deliver comprehensive
measurements of 3D deformation of the human brain, in males and females of different ages, caused by skull
motions of different types, directions, and frequency content. We will then develop methods to use these data to
build and evaluate computer models of traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE).
Such data and methods to exploit them will enable the next generation of computer models to predict the chronic
effects of repeated head impacts. We will thus address the un-met need for data and data-driven methods to
guide and evaluate computer models of brain injury. We can now measure 3D deformation throughout the
brain caused by (i) harmonic skull motion (using MR elastography, MRE), and (ii) impulsive linear and angular
skull acceleration (using tagged MRI). These measurements can quantify the mechanical vulnerability of the
brain, which will be of great value to three classes of end-users: (A) developers of computer models, who need
these quantitative data and tools to build and assess simulations; (B) makers of protective equipment, who need
data to rationally design helmets and sensors; and (C) clinicians and TBI researchers, who need data to
understand injury mechanisms, design relevant animal studies, and improve therapies. We propose three tasks:
Task 1: Measure brain deformation by MRE during harmonic skull motion of different directions and frequencies;
Task 2: Measure brain deformation by tagged MRI during impulsive skull motion of different directions/durations;
Task 3: Develop and demonstrate data-driven tools to improve computer models of 3D brain deformation.
MR-based measurements will be performed in male and female subjects of different ages to illuminate the effects
of gender and age on the brain’s mechanical vulnerability. Successful completion of these tasks will provide: (i)
new quantitative data that captures age/sex differences in brain mechanics using harmonic motion in a robust
and accessible imaging modality (MRE), (ii) new data to quantify brain deformation under mild impulsive loading,
and (iii) new capability to accurately simulate brain deformation, and to evaluate and interpret model predictions.
This partnership involves researchers with distinct expertise and capabilities at four sites. Washington University;
the Henry Jackson Foundation; Johns Hopkins University; and the University of Delaware. The team will use
novel pulse sequences to efficiently perform 3D MRE at multiple excitation frequencies and directions, and will
apply new analysis methods to find natural frequencies and modes of brain motion from tagged MRI. The
unprecedented data from this project, relating brain deformation to skull motion in subjects of different age and
sex, will be exploited to provide a new framework for modeling the effects of chronic impact on the brain.
项目摘要:这个生物工程研究伙伴关系(BRP)将提供全面的
测量不同年龄的男性和女性的人脑的3D变形,
不同类型、方向和频率的运动。然后,我们将开发使用这些数据的方法,
建立和评估创伤性脑损伤(TBI)和慢性创伤性脑病(CTE)的计算机模型。
这些数据和利用它们的方法将使下一代计算机模型能够预测慢性疾病。
头部反复撞击的影响。因此,我们将解决对数据和数据驱动方法的未满足需求,
指导和评估脑损伤的计算机模型。我们现在可以测量整个
大脑由(i)谐波颅骨运动(使用MR弹性成像,MRE)和(ii)脉冲线性和角度
颅骨加速度(使用标记的MRI)。这些测量可以量化的机械脆弱性,
大脑,这将是非常有价值的三类最终用户:(A)计算机模型的开发人员,谁需要
这些定量数据和工具,以建立和评估模拟;(B)保护设备的制造商,谁需要
合理设计头盔和传感器的数据;以及(C)临床医生和TBI研究人员,他们需要数据来
了解损伤机制,设计相关的动物研究,并改进治疗方法。我们提出三项任务:
任务1:在不同方向和频率的谐波颅骨运动期间通过MRE测量脑变形;
任务2:在不同方向/持续时间的冲击颅骨运动期间通过标记MRI测量脑变形;
任务3:开发并演示数据驱动工具,以改进3D大脑变形的计算机模型。
将在不同年龄的男性和女性受试者中进行基于MR的测量,以阐明影响
性别和年龄对大脑机械脆弱性的影响。顺利完成这些任务将提供:㈠
新的定量数据,捕捉年龄/性别差异的大脑力学使用谐波运动在一个强大的
和可访问的成像模式(MRE),(ii)新的数据,以量化大脑变形下的轻度脉冲负荷,
以及(iii)精确模拟大脑变形以及评估和解释模型预测的新能力。
这种伙伴关系涉及四个地点具有独特专业知识和能力的研究人员。华盛顿大学;
亨利杰克逊基金会、约翰霍普金斯大学和特拉华州大学。该团队将使用
新颖的脉冲序列,以在多个激励频率和方向上有效地执行3D MRE,并且将
应用新的分析方法,从标记的MRI中找到大脑运动的自然频率和模式。的
该项目获得了前所未有的数据,将不同年龄的受试者的大脑变形与头骨运动联系起来,
性别,将被利用,以提供一个新的框架,模拟慢性影响对大脑的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
PHILIP V BAYLY其他文献
PHILIP V BAYLY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('PHILIP V BAYLY', 18)}}的其他基金
MRI Measurement of the Mechanical Vulnerability of the Brain
大脑机械损伤的 MRI 测量
- 批准号:
10656780 - 财政年份:2019
- 资助金额:
$ 4.86万 - 项目类别:
MRI Measurement of the Mechanical Vulnerability of the Brain
大脑机械损伤的 MRI 测量
- 批准号:
10471274 - 财政年份:2019
- 资助金额:
$ 4.86万 - 项目类别:
Connecting the mechanobiology of tissue and cells in cerebral cortical folding
连接大脑皮质折叠中组织和细胞的力学生物学
- 批准号:
10619447 - 财政年份:2019
- 资助金额:
$ 4.86万 - 项目类别:
MRI Measurement of the Mechanical Vulnerability of the Brain
大脑机械损伤的 MRI 测量
- 批准号:
10680435 - 财政年份:2019
- 资助金额:
$ 4.86万 - 项目类别:
MRI Measurement of the Mechanical Vulnerability of the Brain
大脑机械损伤的 MRI 测量
- 批准号:
10246436 - 财政年份:2019
- 资助金额:
$ 4.86万 - 项目类别:
Connecting the mechanobiology of tissue and cells in cerebral cortical folding
连接大脑皮质折叠中组织和细胞的力学生物学
- 批准号:
10402819 - 财政年份:2019
- 资助金额:
$ 4.86万 - 项目类别:
MRI Measurement of the Mechanical Vulnerability of the Brain
大脑机械损伤的 MRI 测量
- 批准号:
10015357 - 财政年份:2019
- 资助金额:
$ 4.86万 - 项目类别:
High-Resolution, Anisotropic MR Elastography of the Brain
高分辨率、各向异性脑部 MR 弹性成像
- 批准号:
10317077 - 财政年份:2019
- 资助金额:
$ 4.86万 - 项目类别:
Connecting the mechanobiology of tissue and cells in cerebral cortical folding
连接大脑皮质折叠中组织和细胞的力学生物学
- 批准号:
10159333 - 财政年份:2019
- 资助金额:
$ 4.86万 - 项目类别:
相似海外基金
EXCESS: The role of excess topography and peak ground acceleration on earthquake-preconditioning of landslides
过量:过量地形和峰值地面加速度对滑坡地震预处理的作用
- 批准号:
NE/Y000080/1 - 财政年份:2024
- 资助金额:
$ 4.86万 - 项目类别:
Research Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328975 - 财政年份:2024
- 资助金额:
$ 4.86万 - 项目类别:
Continuing Grant
SHINE: Origin and Evolution of Compressible Fluctuations in the Solar Wind and Their Role in Solar Wind Heating and Acceleration
SHINE:太阳风可压缩脉动的起源和演化及其在太阳风加热和加速中的作用
- 批准号:
2400967 - 财政年份:2024
- 资助金额:
$ 4.86万 - 项目类别:
Standard Grant
Market Entry Acceleration of the Murb Wind Turbine into Remote Telecoms Power
默布风力涡轮机加速进入远程电信电力市场
- 批准号:
10112700 - 财政年份:2024
- 资助金额:
$ 4.86万 - 项目类别:
Collaborative R&D
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328973 - 财政年份:2024
- 资助金额:
$ 4.86万 - 项目类别:
Continuing Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328972 - 财政年份:2024
- 资助金额:
$ 4.86万 - 项目类别:
Continuing Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332916 - 财政年份:2024
- 资助金额:
$ 4.86万 - 项目类别:
Standard Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332917 - 财政年份:2024
- 资助金额:
$ 4.86万 - 项目类别:
Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328974 - 财政年份:2024
- 资助金额:
$ 4.86万 - 项目类别:
Continuing Grant
Study of the Particle Acceleration and Transport in PWN through X-ray Spectro-polarimetry and GeV Gamma-ray Observtions
通过 X 射线光谱偏振法和 GeV 伽马射线观测研究 PWN 中的粒子加速和输运
- 批准号:
23H01186 - 财政年份:2023
- 资助金额:
$ 4.86万 - 项目类别:
Grant-in-Aid for Scientific Research (B)