Adaptive Immune Receptor Repertoire (AIRR) Community Meeting 2021

这次重新提交的主要目的是召集适应性免疫受体曲目的会议 社区(AIRR-C)于2021年12月发布。提案的公关人员，林赛·考威尔博士，现在是 AIRR-C执行小组委员会(SC)主席。这项提案的提交是在#年进行的 与AIRR-C会议委员会成员密切合作。给定的AIRR包含抗原 T细胞(TCR)、B细胞(BCR)和/或由血浆分泌的抗体(Abs)上的受体- 原始细胞和细胞，并反映了这些群体的克隆组成。随着高吞吐量技术的出现 DNA测序，AIRR-C成为一个草根、多学科和包容性的科学社区 致力于开发生成、分析、存储和共享的方法和标准 AIRR排序(AIRR-SEQ)数据及其关联元数据，遵循公平数据原则和公开- 科学实践。2020年会议是AIRR-C的第五次会议，将于#年在斯克里普斯研究中心举行 与我们的斯克里普斯东道主丹尼斯·伯顿博士合作，并于8-11日在拉霍亚希尔顿酒店隔壁举行 2021年12月。AIRR-C会议SC的成员包括3名女性和3名男性，处于以下各个阶段 从研究生到正教授的职业生涯，来自6个不同的国家；他们的免疫学专业知识 范围广泛，从免疫遗传学到细胞免疫学、生物信息学和计算 科学。他们一起准备了一次令人兴奋的会议，由8个TOP提交了两个科学会议 他们所在领域的科学家，介绍了在基础和生物医学领域使用AIRR-SEQ数据所取得的最新进展 科学。为了推进AIRR-C的目标，计划举办两场挑战赛 “AIRR-C及其使命的可持续性”(小组讨论)和AIRR-SEQ数据与 《系统免疫学》(由4位杰出科学家发表演讲)。如建议书所述，并 支持函，会议将为调查人员和学员提供联网、参与的机会 在AIRR-C工作组中，并在实践教程、海报演示和平台演示中学习 并推动免疫谱系分析领域的发展。AIRR-C会议和执行SC已采取 NIH对多样性计划的新要求铭记在心，并将把所要求的资金用于提供旅行 以及支持来自代表性不足群体的两类与会者：(I)职业生涯初期的科学家 和他们的受训人员，以及(Ii)来自支持代表性不足学生的本地大学的与会者(例如， 位于洛杉矶的查尔斯·德鲁大学、位于南加州的加州州立大学)。该计划包括 与这些机构的接触，以及对职业早期科学家、实习生和其他学生的描述 可以成为我们科学网络中的积极参与者，成为我们7个工作组和/或 2个SC。这次会议旨在为所有人提供深入的学习经验和加强 我们的科学网络；这是一种成熟的方法，可以刺激生物医学领域的合作进步。

The central aim of this re-submission is to convene a meeting of the Adaptive Immune Receptor Repertoire Community (AIRR-C) in December of 2021. The PI of the proposal, Dr. Lindsay Cowell, who is now the Chair of the AIRR-C's Executive Sub-committee (SC). The submission of this proposal was undertaken in close collaboration with the Members of the AIRR-C Meetings SC. A given AIRR comprises the antigen receptors on a population of T cells (TcRs), B cells (BcRs) and/or the antibodies (Abs) secreted by plasma- blasts and cells, and reflects the clonal composition of such populations. With the advent of high-throughput DNA sequencing, the AIRR-C emerged as a grass roots, multidisciplinary and inclusive scientific community dedicated to the development of methods and standards for the generation, analysis, storage and sharing of AIRR sequencing (AIRR-seq) data and its associated metadata, following FAIR-data principles and open- science practices. The 2020 meeting is the fifth AIRR-C meeting and will be held at Scripps Research in partnership with our Scripps host, Dr. Dennis Burton, and next door at the La Jolla Hilton hotel, on 8-11 December 2021. The Members of the AIRR-C Meetings SC comprise 3 women and 3 men at all stages of career from grad student to full professor, and from 6 different countries; their immunological expertise spans a wide range from immunogenetics to cellular immunology, bioinformatics and computational sciences. Together, they have prepared an exciting meeting with two Scientific sessions presented by 8 top scientists in their field, covering current advances made with AIRR-seq data in the Basic and Biomedical Sciences. And, to advance the AIRR-C's goals, two Challenge Sessions are planned to explore “Sustainability for the AIRR-C and its Mission” (a panel discussion) and the relevance of AIRR-seq data to “Systems Immunology” (with presentations by 4 outstanding scientists). As detailed in the proposal and letters of support, the meeting will provide opportunities for investigators and trainees to network, participate in AIRR-C Working Groups and learn in hands-on tutorials, poster presentations and platform presentations and advance the field of immune-repertoire profiling. The AIRR-C Meetings and Executive SCs have taken NIH's new requirement for a diversity plan to heart, and will commit the requested funds to providing travel and lodging support for two types of attendees from under-represented groups: (i) early-career scientists and their trainees, and (ii) attendees from local universities that support under-represented students (e.g., Charles Drew University in LA, the local Cal State Universities in Southern California). This plan includes outreach to these institutions, and a description for how early-career scientists, trainees and other students could become active participants within our scientific networks as members of our 7 Working Groups and/or 2 SCs. This conference is meant to provide a deep learning experience for all and a chance to strengthen our scientific networks; this is a proven approach to stimulating collaborative advances in biomedicine.