Adaptive Immune Receptor Repertoire (AIRR) Community Meeting 2021

2021 年适应性免疫受体库 (AIRR) 社区会议

• 批准号: 10391133
• 负责人: LINDSAY G. COWELL
• 金额: $ 1万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-22 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391133
• 关键词: Address; Alleles; Antibodies; Antigen Receptors; Antigens; Area; B-Cell Antigen Receptor; B-Lymphocytes; Big Data; Bioinformatics; Biological; Blast Cell; California; Cellular Immunology; Collaborations; Communication; Communities; Computational Science; Computer software; Country; Data; Data Analyses; Data Set; Databases; Diagnosis; Diagnostic; Dimensions; Disease; Educational process of instructing; Ethics; Evaluation; FAIR principles; Funding; Future; Generations; Genes; Glues; Goals; Haplotypes; Health; Heart; High-Throughput DNA Sequencing; High-Throughput Nucleotide Sequencing; Human; Immune; Immune response; Immune system; Immunity; Immunogenetics; Immunoglobulins; Immunologic Monitoring; Immunologic Receptors; Immunologics; Immunology; Individual; Institution; International; Learning; Legal; Letters; Literature; Memory; Mentors; Metadata; Mission; National Institute of Allergy and Infectious Disease; Nationalities; Nomenclature; Paper; Participant; Pattern; Persons; Plant Roots; Plasma; Poaceae; Population; Process; Progress Reports; Quality Control; Receptor Cell; Research; Research Personnel; Resources; Review Committee; Running; Sampling; Science; Scientist; Socialization; Speed; Standardization; Students; System; T-Cell Receptor; T-Lymphocyte; T-cell receptor repertoire; Technology; Therapeutic antibodies; Tissues; Travel; Underrepresented Populations; United States National Institutes of Health; Universities; Validation; Variant; Visualization; Woman; Work; analysis pipeline; base; cancer immunotherapy; career; computerized tools; data repository; data sharing; data standards; deep learning; diversity and inclusion; experience; experimental study; frontier; immunoglobulin B; interest; interoperability; meetings; member; men; method development; multidisciplinary; open data; outreach; posters; recruit; response; senior faculty; skills; symposium; vaccine development; vaccine-induced antibodies; virtual; volunteer; webinar; working group

The central aim of this re-submission is to convene a meeting of the Adaptive Immune Receptor Repertoire Community (AIRR-C) in December of 2021. The PI of the proposal, Dr. Lindsay Cowell, who is now the Chair of the AIRR-C's Executive Sub-committee (SC). The submission of this proposal was undertaken in close collaboration with the Members of the AIRR-C Meetings SC. A given AIRR comprises the antigen receptors on a population of T cells (TcRs), B cells (BcRs) and/or the antibodies (Abs) secreted by plasma- blasts and cells, and reflects the clonal composition of such populations. With the advent of high-throughput DNA sequencing, the AIRR-C emerged as a grass roots, multidisciplinary and inclusive scientific community dedicated to the development of methods and standards for the generation, analysis, storage and sharing of AIRR sequencing (AIRR-seq) data and its associated metadata, following FAIR-data principles and open- science practices. The 2020 meeting is the fifth AIRR-C meeting and will be held at Scripps Research in partnership with our Scripps host, Dr. Dennis Burton, and next door at the La Jolla Hilton hotel, on 8-11 December 2021. The Members of the AIRR-C Meetings SC comprise 3 women and 3 men at all stages of career from grad student to full professor, and from 6 different countries; their immunological expertise spans a wide range from immunogenetics to cellular immunology, bioinformatics and computational sciences. Together, they have prepared an exciting meeting with two Scientific sessions presented by 8 top scientists in their field, covering current advances made with AIRR-seq data in the Basic and Biomedical Sciences. And, to advance the AIRR-C's goals, two Challenge Sessions are planned to explore “Sustainability for the AIRR-C and its Mission” (a panel discussion) and the relevance of AIRR-seq data to “Systems Immunology” (with presentations by 4 outstanding scientists). As detailed in the proposal and letters of support, the meeting will provide opportunities for investigators and trainees to network, participate in AIRR-C Working Groups and learn in hands-on tutorials, poster presentations and platform presentations and advance the field of immune-repertoire profiling. The AIRR-C Meetings and Executive SCs have taken NIH's new requirement for a diversity plan to heart, and will commit the requested funds to providing travel and lodging support for two types of attendees from under-represented groups: (i) early-career scientists and their trainees, and (ii) attendees from local universities that support under-represented students (e.g., Charles Drew University in LA, the local Cal State Universities in Southern California). This plan includes outreach to these institutions, and a description for how early-career scientists, trainees and other students could become active participants within our scientific networks as members of our 7 Working Groups and/or 2 SCs. This conference is meant to provide a deep learning experience for all and a chance to strengthen our scientific networks; this is a proven approach to stimulating collaborative advances in biomedicine.

这次重新提交的中心目的是召开一次适应性免疫受体库会议 社区（AIRR-C）于2021年12月。该提案的PI，林赛考威尔博士，谁是现在的 AIRR-C执行小组委员会主席。该提案的提交是在 与AIRR-C会议SC的成员密切合作。给定的AIRR包含抗原 T细胞（TcR）、B细胞（BcR）群体上的受体和/或由血浆分泌的抗体（Ab）， 原始细胞和细胞，并反映了这些群体的克隆组成。随着高通量技术的出现， DNA测序，AIRR-C成为一个基层，多学科和包容性的科学社区 致力于开发用于生成、分析、存储和共享 AIRR测序（AIRR-seq）数据及其相关元数据，遵循FAIR数据原则和开放式 科学实践。2020年会议是第五次AIRR-C会议，将在斯克里普斯研究中心举行， 与我们的斯克里普斯主机，丹尼斯伯顿博士，并在隔壁的拉霍亚希尔顿酒店，在8-11 二零二一年十二月。AIRR-C会议SC的成员包括3名女性和3名男性，在所有阶段， 从格拉德生到教授，来自6个不同的国家;他们的免疫学专业知识 从免疫遗传学到细胞免疫学，生物信息学和计算 以理工科为重他们一起准备了一个令人兴奋的会议，由8位顶级科学家提出的两个科学会议， 科学家在他们的领域，涵盖目前的进展与AIRR-seq数据在基础和生物医学 以理工科为重而且，为了推进AIRR-C的目标，计划举办两次挑战赛， “AIRR-C及其使命的可持续性”（小组讨论）以及AIRR-seq数据与 “系统免疫学”（4位杰出科学家的演讲）。如提案中所述， 支持信，会议将为调查人员和受训人员提供机会， 在AIRR-C工作组中学习，并在实践教程、海报演示和平台演示中学习 并推进免疫谱分析领域。AIRR-C会议和执行委员会已经采取了 国家卫生研究院的多元化计划的新要求，并将承诺所要求的资金提供旅行 为来自代表性不足群体的两类与会者提供住宿支持：（i）早期职业科学家 及其学员，以及（ii）来自支持代表性不足的学生的当地大学的与会者（例如， 洛杉矶的查尔斯德鲁大学，南加州的当地加州州立大学）。该计划包括 对这些机构的宣传，以及对早期职业科学家，受训人员和其他学生如何 作为我们7个工作组的成员，可以成为我们科学网络的积极参与者，和/或 2个SC。本次会议旨在为所有人提供深入的学习体验，并有机会加强 我们的科学网络;这是一个行之有效的方法，以刺激生物医学的合作进步。