COVID-19 Mother Baby Outcomes (COMBO): brain-behavior functioning

COVID-19 母婴结果 (COMBO)：大脑行为功能

• 批准号: 10391554
• 负责人: DANI DUMITRIU
• 金额: $ 75.22万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-12 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10391554
• 关键词: 2019-nCoV; Affect; Behavior; Biological Markers; Brain; COVID-19; COVID-19 detection; COVID-19 pandemic; COVID-19 pandemic effects; COVID-19 severity; Caring; Characteristics; Child; Childhood; Civilization; Clinical; Data; Development; Disadvantaged minority; Disease; Electroencephalography; Enrollment; Ethnic Origin; Etiology; Exposure to; Face; Functional disorder; Future; Health; Home; Hospitals; Infant; Infection; Intervention; Lead; Life; Long-Term Effects; Magnetic Resonance Imaging; Mediation; Medical center; Mental Depression; Mental Health; Mood Disorders; Mothers; Neighborhoods; Newborn Infant; Outcome; Pathway interactions; Pediatrics; Physiological; Play; Population; Positioning Attribute; Postpartum Period; Pregnancy; Pregnant Women; Provider; Psychologist; Questionnaires; Race; Risk; SARS-CoV-2 exposure; SARS-CoV-2 positive; Sampling; Science; Scientist; Serology; Serology test; Smell Perception; Stress; Structure; Testing; Universities; Vertical Disease Transmission; Viral; Woman; brain behavior; caregiving; cohort; emotion dysregulation; heart rate variability; immune activation; indexing; innovation; insight; low socioeconomic status; maternal stress; member; minority communities; multidisciplinary; multimodality; neurobehavioral; neurodevelopment; next generation; novel virus; pandemic disease; pediatrician; perceived stress; pregnant; prenatal; prenatal exposure; recruit; routine care; sex

ABSTRACT The devastating effects of the COVID-19 pandemic have reverberated through every aspect of our civilization. While SARS-CoV-2, the viral etiology of COVID-19, seems to spare infants in terms of actual infection, it is currently unknown whether maternal infection during pregnancy will have long-term effects on children born during the pandemic. A variety of prenatal insults, including infections and stress, are well-known to lead to increased risk of affective disorders in both mother and child. With its disproportionate reach into already disadvantaged minority communities, the impact of the COVID-19 pandemic on the dyad is currently unknown and potentially of unprecedented magnitude with enduring consequences for women's mental health and children's developmental origins of health and disease (DOHaD). The COVID-19 Mother Baby Outcome (COMBO) initiative, a large multidisciplinary collaborative, was established at Columbia University Irving Medical Center to follow SARS-CoV-2 exposed laboring mothers and their newborns and compare their long- term health outcomes to case-matched dyads without prenatal exposure. This proposal will follow a subset of the larger COMBO cohort to study socioemotional circuits (fronto-limbic) and behavior (caregiving and bonding) in 100 mother-child dyads from prepartum to 18 months postpartum. The team assembled to carry out this study consists of two provider scientists (Dumitriu, pediatrician and neuroscientist, & Monk, clinical psychologist embedded in Ob/Gyn) and neuroscientist/pediatric neuroimager (Marsh). Using an innovative dyadic approach, olfaction testing, multimodal MRI, wearable in-home physiological recordings, observational mother and child assessments (free play, routine care, Harvard Reactivity and Still Face paradigms), this proposal will test the overarching hypothesis that prenatal SARS-CoV-2 exposure affects (1) mother and (2) child brain and behavior, and (3) demonstrate that the socioemotional health of each member of the mother- child dyad is intrinsically related to that of the other. Detecting COVID-19-related early neurobehavioral effects on mothers and the next generation will provide insights into intervention strategies and contribute significantly to DOHaD and stress science.

摘要 COVID-19大流行的破坏性影响波及我们文明的方方面面。 虽然SARS-CoV-2（COVID-19的病毒病因）在实际感染方面似乎可以避免婴儿，但它 目前尚不清楚母亲在怀孕期间感染是否会对出生的儿童产生长期影响 在大流行期间。众所周知，各种产前损伤，包括感染和压力，会导致 母亲和孩子情感障碍的风险增加。由于其不成比例的影响力已经进入 弱势的少数民族社区，COVID-19大流行对二元的影响目前尚不清楚 而且可能达到前所未有的程度，对妇女的心理健康产生持久的影响， 儿童健康和疾病的发展起源（DOHaD）。COVID-19母婴结局 （COMBO）倡议，一个大型的多学科合作，成立于哥伦比亚大学欧文 医学中心跟踪SARS-CoV-2暴露的分娩母亲及其新生儿，并比较他们的长期 长期健康结果的情况下匹配的二元没有产前暴露。该提案将遵循以下子集： 更大的COMBO队列研究社会情绪回路（额叶边缘系统）和行为（认知和行为）。 在100个母子二人组中，从产前到产后18个月。队伍集合起来， 这项研究由两名提供者科学家（Dumitriu，儿科医生和神经科学家，以及Monk，临床 嵌入Ob/Gyn的心理学家）和神经科学家/儿科神经成像仪（Marsh）。使用创新的 二元方法，嗅觉测试，多模式MRI，可穿戴式家庭生理记录，观察 母亲和儿童评估（自由玩耍，常规护理，哈佛反应性和静止面孔范式），这 这项提案将检验产前SARS-CoV-2暴露影响（1）母亲和（2） 孩子的大脑和行为，和（3）证明，社会情绪健康的每个成员的母亲- 子二分体与另一个子二分体有着内在的联系。检测COVID-19相关的早期神经行为影响 对母亲和下一代的影响将为干预战略提供见解， to DOHaD and stress应力science科学.