COVID-19 Mother Baby Outcomes (COMBO): brain-behavior functioning

摘要 新冠肺炎大流行的破坏性影响已经波及到我们文明的方方面面。 虽然新冠肺炎的病原体SARS-CoV-2似乎在实际感染婴儿方面没有受到影响，但事实并非如此 目前尚不清楚孕期母体感染是否会对新生儿产生长期影响 在大流行期间。众所周知，各种产前侮辱，包括感染和压力，都会导致 增加母亲和孩子患情感障碍的风险。随着它的不成比例的触角已经进入 在弱势少数群体中，新冠肺炎大流行对弱势群体的影响目前尚不清楚 可能会对女性的心理健康和 儿童健康和疾病的发育起源(DOHAD)。《新冠肺炎》母婴结局 (COMBO)倡议是一个大型的多学科合作项目，在哥伦比亚大学欧文分校成立 医学中心将跟踪接触SARS-CoV-2的分娩母亲及其新生儿，并比较她们的长期生存时间 没有产前暴露的病例匹配的二元体的足月健康结局。这项提案将遵循以下几点 研究社会情绪回路(额叶-边缘)和行为(照顾和 从产前到产后18个月的100对母子双方的亲子关系)。这支队伍集合起来准备搬运 这项研究由两名提供研究的科学家(儿科医生和神经学家Dumitriu和临床科学家Monk)组成 嵌入妇产科的心理学家)和神经科学家/儿科神经成像师(马什)。使用创新的 并元方法、嗅觉测试、多模式核磁共振、可穿戴式家庭生理记录、观察性 母子评估(自由玩耍、常规护理、哈佛反应和仍然面对范例)，这 该提案将检验主要假设，即产前接触SARS-CoV-2会影响(1)母亲和(2) 儿童的大脑和行为，以及(3)表明母亲的每个成员的社会情绪健康- 儿童的二元性与另一个的本质上是相关的。检测新冠肺炎相关的早期神经行为效应 将提供对干预策略的见解，并做出重大贡献 为了国防部和强调科学。

ABSTRACT The devastating effects of the COVID-19 pandemic have reverberated through every aspect of our civilization. While SARS-CoV-2, the viral etiology of COVID-19, seems to spare infants in terms of actual infection, it is currently unknown whether maternal infection during pregnancy will have long-term effects on children born during the pandemic. A variety of prenatal insults, including infections and stress, are well-known to lead to increased risk of affective disorders in both mother and child. With its disproportionate reach into already disadvantaged minority communities, the impact of the COVID-19 pandemic on the dyad is currently unknown and potentially of unprecedented magnitude with enduring consequences for women's mental health and children's developmental origins of health and disease (DOHaD). The COVID-19 Mother Baby Outcome (COMBO) initiative, a large multidisciplinary collaborative, was established at Columbia University Irving Medical Center to follow SARS-CoV-2 exposed laboring mothers and their newborns and compare their long- term health outcomes to case-matched dyads without prenatal exposure. This proposal will follow a subset of the larger COMBO cohort to study socioemotional circuits (fronto-limbic) and behavior (caregiving and bonding) in 100 mother-child dyads from prepartum to 18 months postpartum. The team assembled to carry out this study consists of two provider scientists (Dumitriu, pediatrician and neuroscientist, & Monk, clinical psychologist embedded in Ob/Gyn) and neuroscientist/pediatric neuroimager (Marsh). Using an innovative dyadic approach, olfaction testing, multimodal MRI, wearable in-home physiological recordings, observational mother and child assessments (free play, routine care, Harvard Reactivity and Still Face paradigms), this proposal will test the overarching hypothesis that prenatal SARS-CoV-2 exposure affects (1) mother and (2) child brain and behavior, and (3) demonstrate that the socioemotional health of each member of the mother- child dyad is intrinsically related to that of the other. Detecting COVID-19-related early neurobehavioral effects on mothers and the next generation will provide insights into intervention strategies and contribute significantly to DOHaD and stress science.