Structural and Social Determinants of Maternal Mental Health, Morbidity, and Inequities in COMBO
COMBO 中孕产妇心理健康、发病率和不平等的结构和社会决定因素
基本信息
- 批准号:10393379
- 负责人:
- 金额:$ 88.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-12 至 2026-01-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAcculturationAdministrative SupplementAffectAntibodiesAnxietyBioinformaticsBrainBrain imagingBuffersCOVID-19COVID-19 diagnosisCOVID-19 pandemicColorCommunitiesDataDiagnosisDiscipline of NursingDiscipline of obstetricsDiscriminationDistressEconomicsElectronic Health RecordElementsEmergency department visitEmploymentEnrollmentEpidemicEthnic OriginEventFaceFoodHealthHousingHuman RightsIncomeInfantInfrastructureInstitutionInsurance CoverageInterventionInterviewLanguageLatinxLawsLeadershipMagnetic Resonance ImagingMaternal HealthMaternal MortalityMeasuresMedical centerMental DepressionMental HealthMethodsMinorityMorbidity - disease rateMothersNational Institute of Mental HealthNeighborhoodsNeurosciencesNew York CityNewborn InfantOutcomeParentsPerinatalPersonal SatisfactionPhenX ToolkitPoliciesPostpartum PeriodPostpartum WomenPregnancyPregnant WomenPsychosesPublic HealthQuality of CareRaceResearchRiskSARS-CoV-2 exposureSARS-CoV-2 infectionSARS-CoV-2 positiveSamplingSocial DiscriminationSocial supportSocioeconomic StatusStructural RacismStructureSurveysTechniquesTestingTimeTime trendTranslationsUnited States National Institutes of HealthUniversitiesVaccinesWomanWomen StatusWomen&aposs Healthadverse outcomebrain behaviorcohortcommunity based participatory researchcopingdata harmonizationethnic minority populationexperiencefood insecurityhealth disparityindexinglow socioeconomic statusmaternal morbiditymortality riskmultidisciplinaryneuroimagingnovelpandemic diseasepatient orientedperceived stressperinatal mental healthpregnantprenatalprenatal exposureprogramspsychiatric emergencypsychological distressracial and ethnicresiliencesocialsocial determinantssocial disadvantagesocial disparitiessocial epidemiologysocial exclusionsocial health determinantssocial stigmastatisticsstress managementtheories
项目摘要
ABSTRACT
The COVID-19 pandemic has highlighted and exacerbated health disparities related to structural racism and
discrimination (SRD), economic marginalization, and other social determinants of health (SDOH). Pregnant
and postpartum women face unique social and health vulnerabilities related to the pandemic, including risk for
stigma, housing, food, income and employment insecurity, psychological distress, and even mortality – risks
and consequences which are disproportionately significant and adverse for women of color and low
socioeconomic status (SES). However, the collision of these multiple intersecting 21st century public health
crises have not yet been empirically or rigorously studied for inequities in maternal mental health and severe
morbidity. The COVID-19 Mother Baby Outcome (COMBO) initiative is a large multidisciplinary collaborative
established at Columbia University Irving Medical Center to follow SARS-CoV-2 exposed laboring mothers and
their newborns and compare their long-term health and wellbeing to case-matched dyads without prenatal
exposure. The focus of the parent NIMH ‘COMBO’ R01 MH126531 is to understand the effects of SARS-CoV-
2 on mother-infant brain-behavior functioning in a subset of 100 COMBO-enrolled dyads with and without
prenatal SARS-COV-2 infections. Responding to key priorities of NOSI NOT-OD-21-071 and leveraging
COMBO’s robust infrastructure, this administrative supplement (PA-20-272) expands the parent R01 to study
the independent and interactive effects of SRD/SDOH and SARS-CoV-2 on inequities in maternal mental
health, taking advantage of COMBO’s unique setting (first pandemic epicenter) and understudied socially
disadvantaged sample (>600 mother-infant dyads enrolled to-date, with 63% mothers identifying as
racial/ethnic minority and/or low-SES women). By expanding parent R01 brain imaging, surveys, semi-
structured interviews, and electronic health record (EHR) extraction, we will test the overarching hypothesis
that SRD/SDOH and SARS-CoV-2 independently and additively increase risk of adverse maternal mental
health outcomes, with the magnitude of the negative impact being greatest for women of social disadvantage
and the health disparity gap ballooning during – and persisting post – the pandemic. Findings will inform
patient-centered, multi-level interventions to ameliorate the intersecting epidemics of SRD/SDOH and SARS-
CoV-2 and their mental health sequelae for women of social disadvantage in NYC and beyond.
摘要
项目成果
期刊论文数量(0)
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{{ truncateString('DANI DUMITRIU', 18)}}的其他基金
COVID-19 Mother Baby Outcomes (COMBO): brain-behavior functioning
COVID-19 母婴结果 (COMBO):大脑行为功能
- 批准号:
10391554 - 财政年份:2021
- 资助金额:
$ 88.15万 - 项目类别:
COVID-19 Mother Baby Outcomes (COMBO): brain-behavior functioning
COVID-19 母婴结果 (COMBO):大脑行为功能
- 批准号:
10580605 - 财政年份:2021
- 资助金额:
$ 88.15万 - 项目类别:
Live-imaging and characterization of estrogen-induced dendritic spines
雌激素诱导的树突棘的实时成像和表征
- 批准号:
7627182 - 财政年份:2008
- 资助金额:
$ 88.15万 - 项目类别:
Live-imaging and characterization of estrogen-induced dendritic spines
雌激素诱导的树突棘的实时成像和表征
- 批准号:
7485999 - 财政年份:2008
- 资助金额:
$ 88.15万 - 项目类别:
Live-imaging and characterization of estrogen-induced dendritic spines
雌激素诱导的树突棘的实时成像和表征
- 批准号:
8056619 - 财政年份:2008
- 资助金额:
$ 88.15万 - 项目类别:
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