COVID-19 Mother Baby Outcomes (COMBO): brain-behavior functioning

COVID-19 母婴结果 (COMBO)：大脑行为功能

• 批准号: 10580605
• 负责人: DANI DUMITRIU
• 金额: $ 70.25万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-12 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10580605
• 关键词: 2019-nCoV; Affect; Behavior; Biological Markers; Brain; COVID-19; COVID-19 detection; COVID-19 pandemic; COVID-19 pandemic effects; COVID-19 severity; Caring; Characteristics; Child; Childhood; Civilization; Clinical; Data; Development; Disadvantaged minority; Disease; Electroencephalography; Emotional; Enrollment; Ethnic Origin; Etiology; Exposure to; Face; Functional disorder; Future; Health; Home; Hospitals; Infant; Infection; Intervention; Life; Long-Term Effects; Magnetic Resonance Imaging; Mediation; Medical center; Mental Depression; Mental Health; Mood Disorders; Mothers; Neighborhoods; Newborn Infant; Outcome; Pathway interactions; Pediatrics; Physiological; Play; Population; Positioning Attribute; Postpartum Period; Pregnancy; Pregnant Women; Provider; Psychologist; Questionnaires; Race; Risk; SARS-CoV-2 exposure; SARS-CoV-2 positive; Sampling; Science; Scientist; Serology; Serology test; Smell Perception; Stress; Structure; Testing; Universities; Vertical Transmission; Viral; Woman; brain behavior; caregiving; cohort; emotion dysregulation; heart rate variability; immune activation; indexing; innovation; insight; low socioeconomic status; maternal stress; member; minority communities; multidisciplinary; multimodality; neurobehavioral; neurodevelopment; next generation; novel virus; pandemic disease; pediatrician; perceived stress; pregnant; prenatal; prenatal exposure; recruit; routine care; sex

ABSTRACT The devastating effects of the COVID-19 pandemic have reverberated through every aspect of our civilization. While SARS-CoV-2, the viral etiology of COVID-19, seems to spare infants in terms of actual infection, it is currently unknown whether maternal infection during pregnancy will have long-term effects on children born during the pandemic. A variety of prenatal insults, including infections and stress, are well-known to lead to increased risk of affective disorders in both mother and child. With its disproportionate reach into already disadvantaged minority communities, the impact of the COVID-19 pandemic on the dyad is currently unknown and potentially of unprecedented magnitude with enduring consequences for women's mental health and children's developmental origins of health and disease (DOHaD). The COVID-19 Mother Baby Outcome (COMBO) initiative, a large multidisciplinary collaborative, was established at Columbia University Irving Medical Center to follow SARS-CoV-2 exposed laboring mothers and their newborns and compare their long- term health outcomes to case-matched dyads without prenatal exposure. This proposal will follow a subset of the larger COMBO cohort to study socioemotional circuits (fronto-limbic) and behavior (caregiving and bonding) in 100 mother-child dyads from prepartum to 18 months postpartum. The team assembled to carry out this study consists of two provider scientists (Dumitriu, pediatrician and neuroscientist, & Monk, clinical psychologist embedded in Ob/Gyn) and neuroscientist/pediatric neuroimager (Marsh). Using an innovative dyadic approach, olfaction testing, multimodal MRI, wearable in-home physiological recordings, observational mother and child assessments (free play, routine care, Harvard Reactivity and Still Face paradigms), this proposal will test the overarching hypothesis that prenatal SARS-CoV-2 exposure affects (1) mother and (2) child brain and behavior, and (3) demonstrate that the socioemotional health of each member of the mother- child dyad is intrinsically related to that of the other. Detecting COVID-19-related early neurobehavioral effects on mothers and the next generation will provide insights into intervention strategies and contribute significantly to DOHaD and stress science.

摘要