COVID-19 Mother Baby Outcomes (COMBO): brain-behavior functioning

COVID-19 母婴结果 (COMBO)：大脑行为功能

• 批准号: 10580605
• 负责人: DANI DUMITRIU
• 金额: $ 70.25万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-12 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10580605
• 关键词: 2019-nCoV; Affect; Behavior; Biological Markers; Brain; COVID-19; COVID-19 detection; COVID-19 pandemic; COVID-19 pandemic effects; COVID-19 severity; Caring; Characteristics; Child; Childhood; Civilization; Clinical; Data; Development; Disadvantaged minority; Disease; Electroencephalography; Emotional; Enrollment; Ethnic Origin; Etiology; Exposure to; Face; Functional disorder; Future; Health; Home; Hospitals; Infant; Infection; Intervention; Life; Long-Term Effects; Magnetic Resonance Imaging; Mediation; Medical center; Mental Depression; Mental Health; Mood Disorders; Mothers; Neighborhoods; Newborn Infant; Outcome; Pathway interactions; Pediatrics; Physiological; Play; Population; Positioning Attribute; Postpartum Period; Pregnancy; Pregnant Women; Provider; Psychologist; Questionnaires; Race; Risk; SARS-CoV-2 exposure; SARS-CoV-2 positive; Sampling; Science; Scientist; Serology; Serology test; Smell Perception; Stress; Structure; Testing; Universities; Vertical Transmission; Viral; Woman; brain behavior; caregiving; cohort; emotion dysregulation; heart rate variability; immune activation; indexing; innovation; insight; low socioeconomic status; maternal stress; member; minority communities; multidisciplinary; multimodality; neurobehavioral; neurodevelopment; next generation; novel virus; pandemic disease; pediatrician; perceived stress; pregnant; prenatal; prenatal exposure; recruit; routine care; sex

ABSTRACT The devastating effects of the COVID-19 pandemic have reverberated through every aspect of our civilization. While SARS-CoV-2, the viral etiology of COVID-19, seems to spare infants in terms of actual infection, it is currently unknown whether maternal infection during pregnancy will have long-term effects on children born during the pandemic. A variety of prenatal insults, including infections and stress, are well-known to lead to increased risk of affective disorders in both mother and child. With its disproportionate reach into already disadvantaged minority communities, the impact of the COVID-19 pandemic on the dyad is currently unknown and potentially of unprecedented magnitude with enduring consequences for women's mental health and children's developmental origins of health and disease (DOHaD). The COVID-19 Mother Baby Outcome (COMBO) initiative, a large multidisciplinary collaborative, was established at Columbia University Irving Medical Center to follow SARS-CoV-2 exposed laboring mothers and their newborns and compare their long- term health outcomes to case-matched dyads without prenatal exposure. This proposal will follow a subset of the larger COMBO cohort to study socioemotional circuits (fronto-limbic) and behavior (caregiving and bonding) in 100 mother-child dyads from prepartum to 18 months postpartum. The team assembled to carry out this study consists of two provider scientists (Dumitriu, pediatrician and neuroscientist, & Monk, clinical psychologist embedded in Ob/Gyn) and neuroscientist/pediatric neuroimager (Marsh). Using an innovative dyadic approach, olfaction testing, multimodal MRI, wearable in-home physiological recordings, observational mother and child assessments (free play, routine care, Harvard Reactivity and Still Face paradigms), this proposal will test the overarching hypothesis that prenatal SARS-CoV-2 exposure affects (1) mother and (2) child brain and behavior, and (3) demonstrate that the socioemotional health of each member of the mother- child dyad is intrinsically related to that of the other. Detecting COVID-19-related early neurobehavioral effects on mothers and the next generation will provide insights into intervention strategies and contribute significantly to DOHaD and stress science.

抽象的 19009年大流行的毁灭性影响在我们文明的各个方面都回荡。 虽然SARS-COV-2（Covid-19的病毒病因学）似乎在实际感染方面避免了婴儿，但它是 目前尚不清楚怀孕期间的产妇感染是否会对出生的儿童产生长期影响 在大流行期间。众所周知，各种产前侮辱，包括感染和压力，导致 母亲和儿童的情感障碍风险增加。它已经不成比例 处境不利 并且可能存在前所未有的范围，对妇女的心理健康和 儿童健康与疾病的发育起源（DOHAD）。 covid-19-19母亲婴儿的结果 （组合）倡议是一项大型多学科合作，在哥伦比亚大学欧文大学成立 医疗中心跟随SARS-COV-2暴露的劳动母亲及其新生儿，并比较他们的长期 对病例匹配的二元组的健康结果，没有产前暴露。该建议将遵循 研究社会情感电路（额叶）和行为（护理和 键合）在产后18个月的100个母子二元组中。团队聚集起来 这项研究包括两位提供者科学家（Dumitriu，儿科医生和神经科学家，＆MONK，临床 嵌入OB/GYN）和神经科学家/小儿神经imimager（Marsh）的心理学家。使用创新 二元方法，嗅觉测试，多模式MRI，可穿戴的家庭生理记录，观察性 母亲和儿童评估（免费游戏，常规护理，哈佛反应性以及仍然面临范式）， 提案将检验总体假设，即产前SARS-COV-2暴露会影响（1）母亲和（2） 儿童大脑和行为，（3）证明了母亲每个成员的社会情感健康 Child Dyad与对方的内在相关。检测共vid-19与19的早期神经行为效应 关于母亲和下一代将提供对干预策略的见解，并做出重大贡献 多哈和强调科学。