Neurocognitive & neuropsychiatric impact of chemosensory alterations: Implications of olfactory dysfunction in COVID-19

项目总结 嗅觉丧失是SARS-CoV-2新型冠状病毒感染后常见的神经感觉障碍。 观察嗅觉能力改变或嗅觉障碍(OD)的频率和持久性 在新冠肺炎大流行期间，突出了一种知识缺口，在这种情况下，风险因素预测病毒后OD和 随后的神经功能障碍仍然知之甚少。这份K23提案的特点将是 新冠肺炎感染后与OD相关的流行病学危险因素，这反过来可能意味着风险 用于日常功能和生活质量中的神经认知和神经心理障碍。作为一种职业 发展奖，这项提议将提供乔纳森·奥维德韦斯特博士，医学博士，博士，助理教授 哥伦比亚大学欧文医学中心耳鼻咽喉头颈外科 (CUIMC)进行有组织的培训，以建立一个独立的职业生涯，研究嗅觉障碍和 神经认知。在他的主要导师D.P.Devanand的指导下，以及一个经验丰富的 专家，OverDevest博士将在设计和分析以化学传感为重点的领域开发专业知识 使用以患者为中心的研究(POR)方法的神经流行病学研究。在初步的基础上构建 在CUIMC服务的弱势少数民族人群中，评估吸毒流行率和持久性的数据，Dr。 OverDevest将为在这一多种族人口中进行纵向队列研究开发框架。这个 AIM 1的研究将调查新冠肺炎后原发和持续性OD的流行病学危险因素 用主观功能域和以测试为基础的客观工具评估OD感染。在《目标2》中，他将 研究持续性过量与神经学、神经认知和神经精神病学的关系 使用来自多语言NIH工具箱评估单元的经过验证的措施来发挥作用。到时候他会的 通过利用现有的本地研究基础设施，将这项初步工作扩展到神经成像领域 以及他的指导团队的专业知识，以开发将OD和神经学特征关联起来的试点数据 脑部解剖学和炎症性改变的结果。这些研究将为以下战略提供参考 为公众提供有关人口统计学风险因素的咨询，以体验新冠肺炎相关的成瘾，关联风险 为更多的神经功能障碍，并为未来的成像研究提供了基础 评估嗅觉中枢处理和监测OD临床试验结果的方法 干预措施。

PROJECT SUMMARY Smell loss is a common neurosensory disability accompanying infection with SARS-CoV-2 novel coronavirus. The frequency and persistence of alteration in the ability to smell, or olfactory dysfunction (OD), observed during the COVID-19 pandemic highlight a knowledge gap, where risk factors predicting post-viral OD and subsequent neurological dysfunction remain poorly understood. This K23 proposal will characterize epidemiological risk factors associated with OD following COVID-19 infections, which in turn may signify risk for neurocognitive and neuropsychological impairment in daily functioning and quality of life. As a career development award, this proposal will provide Dr. Jonathan Overdevest, MD, PhD, an Assistant Professor in the Department of Otolaryngology-Head and Neck Surgery at Columbia University Irving Medical Center (CUIMC) with structured training to establish an independent career in the study of olfactory dysfunction and neurocognition. Under the guidance of his primary mentor, D.P. Devanand, and an experienced team of experts, Dr. Overdevest will develop domain expertise in the design and analysis of chemosensory-focused neuroepidemiologic studies using patient-oriented research (POR) methodology. Building upon preliminary data evaluating prevalence and persistence of OD in a vulnerable minority population served by CUIMC, Dr. Overdevest will develop the framework for a longitudinal cohort study within this multi-ethnic population. The research in Aim 1 will investigate epidemiologic risk factors for primary and persistent OD following COVID-19 infection by evaluating OD with subjective functional domain and test-based objective tools. In Aim 2, he will study the relationship between persistent OD and neurological, neurocognitive, and neuropsychiatric functioning using validated measures from the multilingual NIH Toolbox assessment battery. He will then extend this preliminary work into the realm of neuroimaging by leveraging existing local research infrastructure and the expertise of his mentorship team to develop pilot data correlating features of OD and neurologic outcomes with anatomic and inflammatory changes in the brain. These studies will inform strategies for counseling the public about demographic risk factors for experiencing COVID-19 related OD, associate risks for additional neurological disabilities, and provide the foundation for future investigation into imaging modalities to evaluate the central processing of olfaction and monitor outcomes of clinical trials for OD interventions.