Neurocognitive & neuropsychiatric impact of chemosensory alterations: Implications of olfactory dysfunction in COVID-19

项目摘要 丧失是伴随SARS-CoV-2新型冠状病毒感染的常见神经感觉障碍。 观察到嗅觉能力改变或嗅觉功能障碍（OD）的频率和持续性 在COVID-19大流行期间，突出了一个知识差距，即预测病毒后OD的风险因素， 后续神经功能障碍仍然知之甚少。K23提案将体现 与COVID-19感染后OD相关的流行病学风险因素，这反过来可能意味着风险 日常功能和生活质量方面的神经认知和神经心理障碍。作为职业 发展奖，这项建议将提供乔纳森Overdevest博士，医学博士，博士，助理教授在 哥伦比亚大学欧文医学中心耳鼻咽喉头颈外科 （CUIMC）通过结构化培训，在嗅觉功能障碍的研究中建立独立的职业生涯， 神经认知在他的主要导师D. P. Devanand和经验丰富的团队的指导下， Overdevest博士将开发领域的专业知识，在设计和分析化学传感器为重点， 神经流行病学研究采用患者导向研究（POR）方法。在初步 数据评估的患病率和持久性的OD在弱势群体的人口服务的CUIMC，博士。 Overdevest将在这个多种族人群中开发纵向队列研究的框架。的 目标1的研究将调查COVID-19后原发性和持续性OD的流行病学风险因素 通过主观功能域和基于测试的客观工具来评估OD。在目标2中，他将 研究持续性OD与神经、神经认知和神经精神的关系 使用来自多语言NIH评估电池的验证措施来发挥作用。随后他将 利用当地现有的研究基础设施，将这项初步工作扩展到神经成像领域 以及他的导师团队的专业知识，以开发与OD和神经系统特征相关的试点数据， 脑内解剖学和炎症变化的结果。这些研究将为以下战略提供信息： 向公众提供关于经历COVID-19相关OD的人口风险因素，相关风险 为其他神经系统残疾，并为未来的成像研究提供基础 评估嗅觉中枢处理和监测OD临床试验结果的模式 干预措施。

PROJECT SUMMARY Smell loss is a common neurosensory disability accompanying infection with SARS-CoV-2 novel coronavirus. The frequency and persistence of alteration in the ability to smell, or olfactory dysfunction (OD), observed during the COVID-19 pandemic highlight a knowledge gap, where risk factors predicting post-viral OD and subsequent neurological dysfunction remain poorly understood. This K23 proposal will characterize epidemiological risk factors associated with OD following COVID-19 infections, which in turn may signify risk for neurocognitive and neuropsychological impairment in daily functioning and quality of life. As a career development award, this proposal will provide Dr. Jonathan Overdevest, MD, PhD, an Assistant Professor in the Department of Otolaryngology-Head and Neck Surgery at Columbia University Irving Medical Center (CUIMC) with structured training to establish an independent career in the study of olfactory dysfunction and neurocognition. Under the guidance of his primary mentor, D.P. Devanand, and an experienced team of experts, Dr. Overdevest will develop domain expertise in the design and analysis of chemosensory-focused neuroepidemiologic studies using patient-oriented research (POR) methodology. Building upon preliminary data evaluating prevalence and persistence of OD in a vulnerable minority population served by CUIMC, Dr. Overdevest will develop the framework for a longitudinal cohort study within this multi-ethnic population. The research in Aim 1 will investigate epidemiologic risk factors for primary and persistent OD following COVID-19 infection by evaluating OD with subjective functional domain and test-based objective tools. In Aim 2, he will study the relationship between persistent OD and neurological, neurocognitive, and neuropsychiatric functioning using validated measures from the multilingual NIH Toolbox assessment battery. He will then extend this preliminary work into the realm of neuroimaging by leveraging existing local research infrastructure and the expertise of his mentorship team to develop pilot data correlating features of OD and neurologic outcomes with anatomic and inflammatory changes in the brain. These studies will inform strategies for counseling the public about demographic risk factors for experiencing COVID-19 related OD, associate risks for additional neurological disabilities, and provide the foundation for future investigation into imaging modalities to evaluate the central processing of olfaction and monitor outcomes of clinical trials for OD interventions.