Mapping of chemosensory neuron function to uncover changes in neuronal fates

绘制化学感应神经元功能图谱以揭示神经元命运的变化

基本信息

  • 批准号:
    10636843
  • 负责人:
  • 金额:
    $ 36.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-02 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

Project Summary Parasitic nematodes infect more than 150 million people worldwide and up to 1.3 billion people benefit from preventative treatment annually. Many parasitic nematodes require insect hosts for transmission to human hosts in their complex life cycles. We use a genetically tractable nematode Pristionchus pacificus that is associated with insects as a comparative model to study how diverse behaviors arise from a limited set of neurons. Our proposed research addresses a fundamental question on how nervous systems evolve to accommodate new behaviors, specifically how and which transcription factors are required to designate the developmental fates of chemosensory neurons in host- seeking behavior. We will use reverse genetics to target candidate transcriptional factors, known as terminal selector genes, as well as inducible transgenes to knock down neuronal function at the single cell level. We will also use forward genetics to investigate unbiasedly which genes are responsible to switch the preferences for taste and smell when the nematodes develop into reproductive adults or host-seeking infectious larvae. A detailed understanding of how neuronal remodeling affects chemosensation could reveal the basic blueprint for sensory neurons found in diverse nematodes, which could inform ways to disrupt the transmission of parasitic nematodes between insect and human hosts.
项目总结

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evolution and Diversity of TGF-β Pathways are Linked with Novel Developmental and Behavioral Traits.
  • DOI:
    10.1093/molbev/msac252
  • 发表时间:
    2022-12-05
  • 期刊:
  • 影响因子:
    10.7
  • 作者:
    Lo, Wen-Sui;Roca, Marianne;Dardiry, Mohannad;Mackie, Marisa;Eberhardt, Gabi;Witte, Hanh;Hong, Ray;Sommer, Ralf J.;Lightfoot, James W.
  • 通讯作者:
    Lightfoot, James W.
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Ray L Hong其他文献

Food size and cGMP affects feeding behaviour in Pristionchus pacificus

Ray L Hong的其他文献

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{{ truncateString('Ray L Hong', 18)}}的其他基金

Administrative Supplements for Curriculum or Training Modules to Enhance Undergraduate Biomedical Research Training: Pre-CURE Modules In Biology
课程或培训模块的行政补充,以加强本科生生物医学研究培训:生物学中的 Pre-CURE 模块
  • 批准号:
    10393442
  • 财政年份:
    2021
  • 资助金额:
    $ 36.25万
  • 项目类别:
Mapping of chemosensory neuron function to uncover changes in neuronal fates
绘制化学感应神经元功能图谱以揭示神经元命运的变化
  • 批准号:
    10460530
  • 财政年份:
    2021
  • 资助金额:
    $ 36.25万
  • 项目类别:
Mapping of chemosensory neuron function to uncover changes in neuronal fates
绘制化学感应神经元功能图谱以揭示神经元命运的变化
  • 批准号:
    10171141
  • 财政年份:
    2021
  • 资助金额:
    $ 36.25万
  • 项目类别:
Elucidating the function of the Lipid-Binding Protein OBI-1 in Pristionchus pacif
阐明太平洋Pristionchus pacif中脂质结合蛋白OBI-1的功能
  • 批准号:
    8692939
  • 财政年份:
    2013
  • 资助金额:
    $ 36.25万
  • 项目类别:
The mode-of-action for pheromone-induced paralysis in Pristionchus pacificus
信息素引起的太平洋原虫麻痹的作用方式
  • 批准号:
    9978066
  • 财政年份:
    2013
  • 资助金额:
    $ 36.25万
  • 项目类别:
Elucidating the function of the Lipid-Binding Protein OBI-1 in Pristionchus pacif
阐明太平洋Pristionchus pacif中脂质结合蛋白OBI-1的功能
  • 批准号:
    9086371
  • 财政年份:
    2013
  • 资助金额:
    $ 36.25万
  • 项目类别:
Elucidating the function of the Lipid-Binding Protein OBI-1 in Pristionchus pacif
阐明太平洋Pristionchus pacif中脂质结合蛋白OBI-1的功能
  • 批准号:
    8871734
  • 财政年份:
    2013
  • 资助金额:
    $ 36.25万
  • 项目类别:
Elucidating the function of the Lipid-Binding Protein OBI-1 in Pristionchus pacif
阐明太平洋Pristionchus pacif中脂质结合蛋白OBI-1的功能
  • 批准号:
    8475301
  • 财政年份:
    2013
  • 资助金额:
    $ 36.25万
  • 项目类别:
Molecular Characterization of Insect Pheromone Chemosensory Mutants in Nematodes
线虫昆虫信息素化学感应突变体的分子表征
  • 批准号:
    8212253
  • 财政年份:
    2010
  • 资助金额:
    $ 36.25万
  • 项目类别:
Molecular Characterization of Insect Pheromone Chemosensory Mutants in Nematodes
线虫昆虫信息素化学感应突变体的分子表征
  • 批准号:
    8015243
  • 财政年份:
    2010
  • 资助金额:
    $ 36.25万
  • 项目类别:

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