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The mode-of-action for pheromone-induced paralysis in Pristionchus pacificus

信息素引起的太平洋原虫麻痹的作用方式

基本信息

批准号：
9978066
负责人：
Ray L Hong
金额：
$ 10.88万
依托单位：
CALIFORNIA STATE UNIVERSITY NORTHRIDGE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2021-08-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9978066
关键词：
Acetonitriles Alleles Animals Anthelmintics Binding Proteins CRISPR/Cas technology Caenorhabditis elegans Candidate Disease Gene Cells Development Developmental Process Drug usage Embryo Evolution Exposure to Gene Expression Genes Genetic Genetic Screening Haemonchus Head Hour Human Hypersensitivity Insecta Larva Lead Lesion Ligands Lipid Binding Livestock Maps Mediating Modeling Mutagenesis Nematoda Nematode infections Neuroglia Neurons Order Coleoptera Paralysed Parasites Parasitic nematode Phenocopy Phenotype Pheromone Pheromone Receptors Phylogenetic Analysis Physiological Population Preventive Medicine Reporter Research Support Resistance Role Sex Attractants Signal Pathway Signal Transduction Transforming Growth Factor beta Transforming Growth Factors Translating Work comparative forward genetics genetic approach genome editing improved loss of function mutant new therapeutic target novel pet animal receptor resistance gene reverse genetics

项目摘要

Project Summary Parasitic nematodes have long harmed crops, pets, livestock, and humans. Wide usage of current broad-spectrum anthelmintics as preventive medicine has led to emerging nematode resistance against these compounds in many human populations, prompting the exploration of compounds with novel genetic targets. Our discovery that an insect pheromone can act both as an attractant as well as an anthelmintic represents a unique opportunity to define a novel drug target. Our proposal is to identify the mode-of-action for this pheromone using a lipid- binding protein as the genetic entry point. We propose three independent strategies involving candidate gene expression and functional analysis, along with forward genetic screens to identify the pheromone receptor and other components of the signaling pathway.

项目摘要寄生线虫长期以来危害农作物、宠物、牲畜和人类。宽目前广谱驱虫药作为预防药物的使用导致在许多人中出现了针对这些化合物的线虫抗性这促使人们探索具有新的遗传靶点的化合物。我们发现昆虫信息素既可以作为引诱剂，驱虫剂代表了确定新药物靶点的独特机会。我们的建议是使用脂质来识别这种信息素的作用模式- 结合蛋白作为遗传入口。我们建议三个独立的涉及候选基因表达和功能分析的策略，沿着通过正向遗传筛选来识别信息素受体和其他信号通路的组成部分。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Antileishmanial activity of a new chloroquine analog in an animal model of Leishmania panamensis infection.

DOI：
10.1016/j.ijpddr.2020.08.002
发表时间：
2020-12
期刊：
International journal for parasitology. Drugs and drug resistance
影响因子：
0
作者：
Herrera L;Llanes A;Álvarez J;Degracia K;Restrepo CM;Rivera R;Stephens DE;Dang HT;Larionov OV;Lleonart R;Fernández PL
通讯作者：
Fernández PL

The bacterial community of entomophilic nematodes and host beetles.