KU Nanofabrication Facility

KU 纳米制造设施

• 批准号: 10414319
• 负责人: Susan M Lunte
• 金额: $ 22.95万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10414319
• 关键词: Biological; Biological Process; Biology; Biomedical Research; Biophysics; Cancer Patient; Cell Communication; Cells; Centers of Research Excellence; Chemicals; Chemistry; Clinical; Clinical Chemistry; Complex; Custom; DNA Sequencing Facility; Development; Devices; Disease Pathway; Engineering; Environment; Equipment; Goals; Growth; Hematopoietic Neoplasms; Human; Human Resources; Infrastructure; Institution; Investigation; Kansas; Lab-On-A-Chips; Laboratories; Methods; Microfabrication; Microfluidic Microchips; Microfluidics; Molecular Analysis; Neoplasm Circulating Cells; Organ; Phase; Physics; Physiological Processes; Privatization; Process; Production; Research; Research Infrastructure; Research Personnel; Resources; Techniques; Technology; Training; Universities; clinical diagnostics; design; drug discovery; drug metabolism; equipment training; exosome; genome sequencing; integrated circuit; interest; laboratory development; nanodevice; nanofabrication; nanofluidic; nanoscale; novel; organ on a chip; outreach

PROJECT SUMMARY – CORE D Over the past twenty-five years, there has been tremendous growth in the development of lab-on-a-chip technologies for clinical, environmental and biological applications. These devices are constructed using fabrication technologies that were originally developed to produce integrated circuits. Similar to integrated circuits, these devices can integrate several different bioanalytical processes into a single platform only a few centimeters in size. Microfluidics have been used for many applications in biomedical research, from analyzing the contents of single cells to mimicking the complex environments of human organs to better understand cell- cell interactions. The KU Nanofabrication Facility is a Core Laboratory supported by the COBRE Center for Molecular Analysis of Disease Pathways at the University of Kansas. It provides the resources and personnel for the production of micro- and nanoscale devices that are used by project investigators for their studies. Equipment and training are available to investigators for the fabrication of devices for biomedical, biophysical, and bioanalytical studies related to disease pathways. The goals of KUNF in Phase 3 are (1) to develop and maintain a Core infrastructure that allows the efficient design and fabrication of nano- and microscale devices for use by project investigators and researchers from the University of Kansas, other regional universities, and private institutions for biomedical research, (2) to provide outreach, training and assistance in the development of nano- and microfluidic devices for the investigation of disease pathways, (3) to provide access to and assistance with the development of nano- and microfluidic devices and to fabricate custom devices for investigators, and (4) to continue developing a critical mass of Core Lab users, so that the facility becomes a self-sustaining, integral part of the biomedical research infrastructure in the state of Kansas and the surrounding region.

项目概要-核心D 在过去的二十五年里，芯片实验室的发展有了巨大的增长 用于临床、环境和生物应用的技术。这些设备是用 这些制造技术最初是为了生产集成电路而开发的。类似于集成 电路，这些设备可以集成几个不同的生物分析过程到一个单一的平台，只有少数 厘米大小。微流体技术已用于生物医学研究中的许多应用，从分析 单细胞的内容，以模拟人体器官的复杂环境，以更好地了解细胞- 细胞相互作用KU纳米纤维设施是由COBRE中心支持的核心实验室， 堪萨斯大学疾病途径的分子分析。它提供资源和人员 用于生产供项目研究人员用于研究的微米和纳米级器件。 为研究人员提供设备和培训，用于制造生物医学，生物物理， 以及与疾病途径相关的生物分析研究。 KUNF在第三阶段的目标是（1）开发和维护一个核心基础设施， 设计和制造纳米和微米级器件，供项目调查人员和研究人员使用， 堪萨斯大学、其他地区性大学和私人生物医学研究机构，（2） 在开发纳米和微流体装置方面提供外联、培训和援助， 调查疾病途径，（3）提供获得和援助，以发展纳米和 微流控设备和制造定制设备的研究人员，和（4）继续开发一个关键的 核心实验室用户的质量，使该设施成为一个自我维持，生物医学研究的组成部分 在堪萨斯州和周边地区的基础设施。