KU Nanofabrication Facility

项目摘要--核心D 在过去的25年里，芯片实验室的发展取得了巨大的增长 临床、环境和生物应用技术。这些设备是使用 制造技术最初是为了生产集成电路而开发的。类似于集成 电路，这些设备可以将几个不同的生物分析过程集成到一个平台上，只有少数几个 公分大小。微流体已经在生物医学研究中得到了许多应用，从分析 将单个细胞的内容物模拟人体器官的复杂环境，以更好地了解细胞- 细胞间的相互作用。KU纳米加工设施是由科布雷中心支持的核心实验室 堪萨斯大学疾病途径的分子分析。它提供了资源和人员 用于生产微米和纳米级的设备，供项目调查人员用于研究。 为研究人员提供设备和培训，用于制造生物医学、生物物理、 以及与疾病途径相关的生物分析研究。 KUNF在第三阶段的目标是(1)开发和维护核心基础设施，以实现高效的 设计和制造纳米和微型设备，供项目调查人员和研究人员使用 堪萨斯大学、其他地区大学和私立生物医学研究机构，(2)至 在开发纳米和微流控设备方面提供外联、培训和援助 调查疾病的途径，(3)提供获得和协助开发纳米技术和 微流控设备和为研究人员制造定制设备，以及(4)继续开发关键的 大量核心实验室用户，使该设施成为生物医学研究自给自足、不可或缺的一部分 堪萨斯州及周边地区的基础设施。

PROJECT SUMMARY – CORE D Over the past twenty-five years, there has been tremendous growth in the development of lab-on-a-chip technologies for clinical, environmental and biological applications. These devices are constructed using fabrication technologies that were originally developed to produce integrated circuits. Similar to integrated circuits, these devices can integrate several different bioanalytical processes into a single platform only a few centimeters in size. Microfluidics have been used for many applications in biomedical research, from analyzing the contents of single cells to mimicking the complex environments of human organs to better understand cell- cell interactions. The KU Nanofabrication Facility is a Core Laboratory supported by the COBRE Center for Molecular Analysis of Disease Pathways at the University of Kansas. It provides the resources and personnel for the production of micro- and nanoscale devices that are used by project investigators for their studies. Equipment and training are available to investigators for the fabrication of devices for biomedical, biophysical, and bioanalytical studies related to disease pathways. The goals of KUNF in Phase 3 are (1) to develop and maintain a Core infrastructure that allows the efficient design and fabrication of nano- and microscale devices for use by project investigators and researchers from the University of Kansas, other regional universities, and private institutions for biomedical research, (2) to provide outreach, training and assistance in the development of nano- and microfluidic devices for the investigation of disease pathways, (3) to provide access to and assistance with the development of nano- and microfluidic devices and to fabricate custom devices for investigators, and (4) to continue developing a critical mass of Core Lab users, so that the facility becomes a self-sustaining, integral part of the biomedical research infrastructure in the state of Kansas and the surrounding region.