Molecular Analysis of Disease Pathways

疾病途径的分子分析

• 批准号: 10414315
• 负责人: Susan M Lunte
• 金额: $ 114.75万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10414315
• 关键词: Basic Science; Biochemical; Biological; Biology; Biomedical Engineering; Biomedical Research; Centers of Research Excellence; Chemicals; Chemistry; Client; DNA Sequencing Facility; Development; Diagnosis; Disease; Disease Pathway; Environment; Faculty; Fees; Funding; Genomics; Goals; Grant; Health; Human; Infrastructure; Institution; Kansas; Laboratories; Mentors; Microfabrication; Microfluidics; Mission; Molecular Analysis; Molecular Biology; Pathway interactions; Phase; Pilot Projects; Positioning Attribute; Process; Request for Applications; Research; Research Personnel; Research Support; Science; Scientist; Services; Synthesis Chemistry; Technology; Universities; base; biomedical resource; career; faculty research; genome sequencing; member; nanofabrication; outreach; programs; recruit; senior faculty; success; voucher

PROJECT SUMMARY – OVERALL The COBRE CMADP was created in July 2012 to encourage basic research scientists to develop and implement new enabling technologies for the study of biological pathways and applied processes related to disease. Over the past nine years, CMADP investigators have pursued health-related research related to the molecular analysis of disease pathways. We have supported 24 junior faculty to date through research support and mentoring. The 18 faculty that have graduated from the program thus far have generated over $38.5 million in external funding. We also established three new Core Laboratories focused on enabling technologies for the study of disease: the Genome Sequencing Core, the Synthetic Chemical Biology Core and the KU Nanofabrication Facility (formerly the Microfabrication & Microfluidics Core). These three Cores brought new and essential enabling technologies to KU, allowing us to attract high-quality biomedical researchers and faculty to Kansas. As a result, CMADP strengthened both the human and the physical resources for biomedical research in the state. This application requests five years of funding for Phase 3 of our COBRE Center to pursue the following objectives: (1) to continue growing a critical mass of new and continuing investigators focused on the very broad theme of molecular analysis of disease pathways, (2) to continue a successful program of COBRE Pilot Project grants that utilize our Core Labs, and (3) to strengthen our existing Core Labs by expanding their capabilities and user bases, working with the KU Office of Research to position them for long-term sustainability based on a combination of fees generated plus a base of support from the University. The result will be a very strong cadre of successful mid-career biomedical research faculty and self-sustaining Core Labs that support research in molecular analysis of disease pathways statewide. We strongly believe that the overall impact of CMADP on biomedical research at KU and the state of Kansas will thus be substantial and enduring.

项目概要-总体 COBRE CMADP创建于2012年7月，旨在鼓励基础研究科学家开发和实施 研究与疾病有关的生物途径和应用过程的新技术。超过 在过去的九年里，CMADP的研究人员一直在进行与分子分析有关的健康相关研究。 疾病的路径。我们已经通过研究支持和指导支持了24名初级教师。的 到目前为止，从该计划毕业的18名教师已经获得了超过3850万美元的外部资金。 我们还建立了三个新的核心实验室，专注于研究疾病的技术： 基因组测序核心，合成化学生物学核心和KU纳米实验室设施（原 Microfabrication & Microfluidics Core）。这三个核心带来了新的和必要的使能技术 到KU，使我们能够吸引高质量的生物医学研究人员和教师到堪萨斯。因此，CMADP 加强了该州生物医学研究的人力和物力资源。本申请 要求为我们的COBRE中心的第三阶段提供五年的资金，以实现以下目标：（1）继续 越来越多的新的和持续的研究人员集中在分子的非常广泛的主题， 分析疾病的途径，（2）继续一个成功的COBRE试点项目赠款计划，利用 我们的核心实验室，以及（3）通过扩大其能力和用户基础来加强我们现有的核心实验室， 与KU研究办公室合作，根据以下组合将其定位为长期可持续性 产生的费用加上大学的支持基础。其结果将是一个非常强大的干部成功 职业中期生物医学研究教师和自我维持的核心实验室，支持分子分析研究 疾病的传播途径我们坚信CMADP对生物医学研究的整体影响 因此，在KU和堪萨斯州的关系将是实质性的和持久的。