Core-008

创新生态系统(合作实现创新价值优化和加速转换 [Pivot])计划将拥抱创新和商业翻译，以推动生物医学发现进入 市场。通过CCTSI的这一可选功能，我们将开发和维持一项创新 计划在商业价值翻译方面教育、培训和发展我们的员工；支持技术人员 开发可商业化的创新；并展示临床和医疗服务的价值和对健康的影响 通过提供获得加速器风险投资资金、领域专业知识、 和商业化指导。Pivot的总体目标是提供一个无缝的、多层次的面向 支持创新想法商业化和产品开发的基础设施，在 过程、支持和学术奖励创业。我们将通过以下几个方面实现这些目标 具体目标：目标1：劳动力。通过以下方式促进学术企业家文化和员工队伍： 和扩大生物创业培训机会的覆盖范围，(B)促进创业网络， 以及(C)为临床和翻译专业的教职员工和研究生展示职业轨迹 科学创新者。目标2：发展。通过以下方式加快发展可商业化创新 通过创新团队(i-Corps™)发现客户并促进i-Corps和Team的组合使用 为获得CCTSI试点奖的创新团队提供科学培训。目标3：展示影响力。加速 通过主动导航到CCTSI生态系统内的资源进行健康影响演示，这些资源提供 商业化指导、领域专业知识和加速器资金。CCTSI轴心计划将服务于 作为整合的导航者和资源倍增器，扩大和延伸创业投资的触角 由科罗拉多大学和科罗拉多州立大学以及科罗拉多大学提供的基础设施支持 经济发展和国际贸易办公室。Pivot还将利用NIH两个独特的员工队伍 科罗拉多州的培训计划：为研究生颁发的拓宽科学培训经验(BEST)奖 临床和翻译科学的实习生；以及I-Corps™培训员培训计划 可扩展的短期课程和适应临床和翻译需求的通用指标 将在CTSA财团中传播的科学计划。与广泛的 由全州、国家和机构创新创业伙伴关系组成的网络，Pivot将领导 通过拥抱创新和商业翻译来实现CCTSI生态系统内的重大学术转变 将生物医学发现推向市场。培育支持创业孵化的文化。 并提供教育和实践培训，以帮助学术企业开发具有商业可行性的产品 和服务。

The Innovation Ecosystem (Partnering for Innovation Value Optimization and Accelerated Translation [PIVOT]) program will embrace innovation and commercial translation to advance biomedical discoveries into the marketplace. Through this Optional Function of the CCTSI, we will develop and sustain an innovation program to educate, train and develop our workforce in commercial value translation; to support the technical development of commercializable innovation; and to demonstrate value and health impact of clinical and translational science innovation by providing access to accelerator venture capital funding, domain expertise, and commercialization mentorship. The overall goal of PIVOT is to provide a seamless, multi-level investigatorfacing infrastructure supporting the commercialization and product development of innovative ideas and, in the process, support and academically reward entrepreneurship. We will achieve these goals through the following specific aims: Aim 1: Workforce. Catalyze an academic entrepreneur culture and workforce by (a) disseminating and expanding the reach of bio-entrepreneurship training opportunities, (b) fostering entrepreneurial networking, and (c) demonstrating career trajectories for faculty and graduate students who are clinical and translational science innovators. Aim 2: Development. Accelerate the development of commercializable innovation through customer discovery by Innovation-Corps (I-Corps™) teams and promote combined usage of I-Corps and Team Science training for innovation teams receiving CCTSI pilot awards. Aim 3: Demonstrate impact. Accelerate health impact demonstration through active navigation to resources within the CCTSI ecosystem which provide commercialization mentorship, domain expertise, and accelerator funding. The CCTSI PIVOT program will serve as an integrator-navigator and resource multiplier to expand and extend the reach of entrepreneurial investment and infrastructure support provided by University of Colorado and Colorado State University and the Colorado Office of Economic Development and International Trade. PIVOT will also capitalize on two unique NIH workforce training programs in Colorado: the Broadening Experiences in Scientific Training (BEST) award for graduate trainees in clinical and translational sciences; and the I-Corps™ Train-the-Trainer program at NCATS to develop a scalable short-course curriculum and common metrics adapted to the needs of clinical and translational science programs that will be disseminated across the CTSA consortium. In collaboration with an extensive network of state-wide, national and institutional innovation and entrepreneurship partnerships, PIVOT will lead a major academic shift within the CCTSI ecosystem by embracing innovation and commercial translation to advance biomedical discoveries into the marketplace. We will foster a culture that supports startup incubation and provides education and practical training to help academic ventures develop commercially-viable products and services.