Core-007

核心007

• 批准号: 10414774
• 负责人: RONALD J. SOKOL
• 金额: $ 31.93万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-11-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10414774
• 关键词: Adolescence; Advisory Committees; Childhood; Clinical; Clinical Trials; Collaborations; Colorado; Communities; Development; Discipline; Disease; Elderly; Fostering; Funding; Generations; Goals; Health; Human; Individual; Institutes; Interdisciplinary Study; Intervention Studies; Life; Life Cycle Stages; Longevity; Maternal and Child Health; Medical; Medicine; Modeling; Pregnant Women; Quality of life; Research; Research Infrastructure; Research Personnel; Research Support; Science; Scientist; Societies; Training; Training and Education; Training and Infrastructure; Translating; Translational Research; Universities; base; burden of illness; career; disorder prevention; early life exposure; economic impact; fetal; improved; infancy; innovation; multidisciplinary; offspring; organizational structure; pre-clinical; programs; prospective; research and development; training opportunity; translational scientist

The overall goal of our Early Life Exposures Program (ELEP) Optional Component is to enable investigators in diverse disciplines and all career stages to train, participate, and excel in research focusing on human health and diseases that have their origins at early stages of life. As a result, the ELEP will foster a new generation of scientists trained in the complexities of translational research involving pregnant women and their offspring from infancy through childhood and adolescence. The premise of our ELEP is that pre-emption of diseases and prevention of their later life consequences will improve health and quality of life by reducing disease burden and its devastating economic impact on individuals and society. Thus ELEP will align with the CTSA Lifespan Domain Task Force through objectives focused on early life exposures. Within the CCTSI framework, the ELEP will integrate a large number of existing and well-funded research programs in maternal-placental-fetal and pediatric medicine, each with multiple investigators and trainees. The ELEP will support new multidisciplinary collaborations among basic/pre-clinical, clinical, and translational scientists at the University of Colorado Anschutz Medical Campus (CU-AMC) and in the CCTSI community. The ELEP will provide research and training infrastructure to facilitate early life exposures research and longitudinal lifespan/life course research. The ELEP will provide an innovative platform for prospective, observational and experimental approaches as a national model for CTSA centers engaged in lifespan research in order to promote collaborations among CTSA hubs. These goals will be achieved by the following Specific Aims: Aim 1: Expand and streamline our broad-based, multidisciplinary organizational structure to promote Early Life Exposures clinical-translational research in the CCTSI. Aim 2: Provide coordinated research support and development. Aim 3: Foster new education and training opportunities in Early Life Exposures research. By implementing these aims over the next 5 years, we will enhance the ability of our numerous outstanding scientists and team-based research programs, and attract and train new investigators, in child-maternal health research to have a significant and sustained impact on human health and development, with the ultimate goal of translating discoveries into interventional studies and clinical trials very early in life with high potential to improve quality of life across the lifespan.

我们的早期生命暴露计划（ELEC）可选组件的总体目标是使研究人员能够 在不同的学科和所有的职业生涯阶段，培训，参与，并在研究重点是人类健康的优秀 以及起源于生命早期的疾病。因此，ELEC将培养新一代的 科学家们在涉及孕妇及其后代的转化研究的复杂性方面接受了培训， 从婴儿期到童年和青春期。我们的ELEP的前提是预先预防疾病， 预防其晚年后果将通过减少疾病负担， 它对个人和社会的破坏性经济影响。因此，ELEP将与CTSA寿命域保持一致 工作队通过目标集中于生命早期的接触。在CCTSI框架内，ELEP将 整合大量现有的和资金充足的研究计划，在母-胎盘-胎儿和儿科 医学，每个都有多名研究人员和受训人员。ELEC将支持新的多学科 科罗拉多大学基础/临床前、临床和转化科学家之间的合作 安舒茨医学院（CU-AMC）和CCTSI社区。ELEP将提供研究和培训 建立基础设施，促进早期生命暴露研究和纵向寿命/生命过程研究。ELEP 将提供一个创新的平台，前瞻性，观察和实验方法，作为一个国家 为从事寿命研究的CTSA中心建立一个模型，以促进CTSA中心之间的合作。 这些目标将通过以下具体目标实现：目标1：扩大和精简我们基础广泛的， 多学科的组织结构，以促进早期生命暴露的临床转化研究， CCTSI。目标2：提供协调一致的研究支持和发展。目标3：促进新的教育和 早期生活暴露研究的培训机会。通过在未来五年实现这些目标，我们 将提高我们众多优秀科学家和团队研究项目的能力，并吸引 并培训新的调查人员，在儿童-孕产妇健康研究中产生重大和持续的影响， 人类健康和发展，最终目标是将发现转化为干预性研究， 在生命早期进行临床试验，具有很大的潜力，可以改善整个生命周期的生活质量。