Collaborative Expansion of Marmoset Colonies for Neuroscience Research

摘要 在生物医学研究中，对常见绒猴(Callithrix Jacchus)的需求大幅增加 在过去的五年里，它们已经成为各种研究学科中一个关键的生物医学模型系统。 在神经科学中，对绒猴的使用增加最为明显，在神经科学中，需要研究认知， 在灵长类动物模型中，行为和精神疾病都有所增加。在非人灵长类动物(NHP)模型中， 绒猴为神经科学研究提供了独特的实用优势，包括体积小，易于操作， 生殖成熟快，繁殖力高，生命周期压缩，社会行为和交流 这与在人类身上观察到的更接近。这些优势也促成了最近的 在使用胚胎新基因组编辑技术的研究中，对绒猴的需求激增。这是最近的 需求的激增导致可供使用的绒猴短缺，估计在2000只左右。 整个研究界每年都需要绒猴，我们自己估计在200只左右- 仅神经科学界的动物数量就不足。西南国家灵长类动物研究中心 (SNPRC)和威斯康星州国家灵长类研究中心(WNPRC)提出了一项重大合作努力 为国家神经科学研究大幅增加健康普通绒猴的供应 项目。为了应对神经科学相关项目中对绒猴的需求激增，SNPRC和 WNPRC提出了一项综合计划，1)将他们的绒猴产量增加一倍，以提供给国家 需要这些实验动物进行神经科学研究的机构，2)继续确保最高 畜牧和兽医护理的标准，因此，这些殖民地的良好健康，3)保持血统 记录和开发基因组数据库，以记录和最大限度地增加扩张者的遗传多样性 绒猴群体，4)两个中心在新的研究中继续合作，重点是改善 畜牧、养殖和兽医做法，以最大限度地提高这些动物的健康和寿命，以及5) 定期与U24 Marmoset群体协调中心和NIH进行沟通 神经科学指导委员会的绒猴。两个全国人民代表大会提出的合作方式是 考虑到可用的资源和专业知识，具有创新性和适当性，并确保成功完成 这些目标导致了神经科学可用的绒猴数量的急剧增加 社区。

Summary Demand for the common marmoset (Callithrix jacchus) in biomedical research has increased tremendously over the past five years, as they have emerged as a critical biomedical model system in a variety of study disciplines. The increased use of marmosets has been most acute in neuroscience, where the need to study cognition, behavior, and mental illness in primate models has grown. Among non-human primate (NHP) models, the marmoset provides unique practical advantages for neuroscientific studies, including small size, easy handling, rapid reproductive maturation, high fecundity, compressed life cycle, and social behaviors and communication that more closely resemble those observed in humans. These advantages have also contributed to the recent surge in the demand for marmosets in studies using embryonic new genomic editing techniques. This recent upsurge in demand has resulted in shortages in availability of marmosets estimated to be in the range of 2000 marmosets needed by the overall research community each year, with our own estimate in the range of a 200- animal shortfall for the neuroscience community alone. The Southwest National Primate Research Center (SNPRC) and the Wisconsin National Primate Research Center (WNPRC) propose a major collaborative effort to dramatically increase the availability of healthy common marmosets for national neuroscience research projects. In response to the upsurge in demand for marmosets in neuroscience-related projects, the SNPRC and WNPRC propose a comprehensive plan to 1) double their output of marmosets for provision to national institutions in need of these experimental animals for neuroscience research, 2) continue to ensure the highest standards of husbandry and veterinary care and thus, the excellent health of these colonies, 3) maintain pedigree records and develop genomic databases to document and maximize genetic diversity among the expanded marmoset colonies, 4) continue collaboration between the two Centers in new studies focused on improving husbandry, breeding, and veterinary practices to maximize the health and lifespan of these animals, and 5) communicate on a regular basis with the U24 Marmoset Colony Coordination Center, and with the NIH Marmosets for Neuroscience Steering Committee. The collaborative approach proposed by the two NPRCs is both innovative and appropriate given the resources and expertise available and ensures successful completion of these aims resulting in a dramatic increase in the number of marmosets available to the neuroscience community.