Comprehensive Mechanisms in Reproductive Sciences

项目概要和摘要 我们的计划目标是培养有才华的年轻科学家从事研究密集型和研究相关的职业 在生殖生物学中。贝勒医学院是生殖生物学研究的长期领导者。 博士前和博士后学员接受生物医学研究和职业发展方面的指导培训 获得各种职业道路所需的技能。博士前课程结合了最先进的培训 沿着教学式的学习。博士后研究员参加课程， 除了他们的研究培训研讨会。双方都将有结构化的委员会进行研究和职业咨询 包括一个正式的口头报告。培训生导师制以特定于项目的个人发展为指导 计划（IDP），与导师和核心执行委员会成员一起制定。活动 提高教学技能，临床/翻译工作，和创业，是由ESTA和邻近提供 世界上最大的医疗中心内的合作机构。项目具体活动包括 期刊俱乐部、年度小型研讨会、研究咨询委员会、导师-学员NRMN模块 培训，口头交流的正式评论，协助发展研究金申请，以及 个人职业规划方案。这些方案还辅以负责任行为的培训， 研究和专门为此建议设计的一个新的“生殖健康伦理学学习单元”。的13 教师已被选定为生殖生物学的当代研究兴趣， 目前获得超过1400万美元的资金支持，仅NICHD的资金就有600万美元（占PI总额的43 资金）。他们的研究领域正好属于NICHD的使命，包括对关键生殖器官的研究。 生物蛋白质，男性和女性生殖组织的正常和病理生理学，遗传和 影响生育力的环境因素和转化研究（男性避孕药的开发和 成人疾病的发展起源）。培训教师使用尖端的方法来研究生殖 使用遗传模型、患者样本、体外模型和临床数据进行处理。我们的计划是为 三名博士预科生和四名博士后研究员。我们计划为学员提供两年的支持， 参加第三年的比赛由于长期的生殖生物学研究计划， 积极的国家招聘战略，我们目前在我们的培训实验室中拥有强大的申请人库，可以从中 挑选学员，包括来自工发组织各团体的博士前和博士后学员。总的来说，我们的计划提供 必要的技能和经验，为下一代科学家的成功和多样化的职业生涯做好准备 在生殖生物学中。

Project Summary and Abstract Our program goal is to train talented young scientists for research-intensive and research-related careers in reproductive biology. Baylor College of Medicine is a long-standing leader in reproductive biology research. Predoctoral and postdoctoral trainees receive mentored training in biomedical research and career development to obtain skills necessary for a variety of career paths. The predoctoral program combines state-of-the-art training in premier reproductive biology laboratories along with didactic learning. Postdoctoral fellows attend courses and seminars alongside their research training. Both will have structured committees for research and career advising that include a formal oral presentation. Trainee mentorship is guided by program-specific Individual Development Plans (IDP), developed in conjunction with the mentor and a core executive committee member. Activities to enhance skills in teaching, clinical/translational work, and entrepreneurship, is offered by BCM and neighboring collaborative institutions within the world's largest medical center. Program specific activities include a mentored journal club, an annual mini-symposium, research advisory committees, NRMN modules for mentor-mentee training, formal critiques of oral communications, assistance with development of fellowship applications, and individual career planning programs. These programs are supplemented with training in responsible conduct of research and a novel “ethics in reproductive health learning unit” specifically designed for this proposal. The 13 faculty members have been selected for contemporary research interests in reproductive biology and are currently supported by over $14 million in funding with $6 million in NICHD funding alone (43% of total PI funding). Their research areas fall squarely within the mission of NICHD, and includes studies of key reproductive biology proteins, normal and pathophysiology of male and female reproductive tissues, genetic and environmental factors that affect fertility, and translational research (male contraceptive development and developmental origins of adult disease). The training faculty use cutting edge approaches to study reproductive processes using genetic models, patient samples, in vitro models, and clinical data. Our program is designed for three predoctoral students and four postdoctoral fellows. We plan to support trainees for two years with an option to compete for a third year. Due to the long-standing reproductive biology research program at BCM and an active national recruiting strategy, we currently have a strong applicant pool in our training labs from which to select trainees, including pre- and postdoctoral trainees from UR groups. In total, our program provides necessary skills and experience to prepare the next generation of scientists for successful and diverse careers in reproductive biology.