Multidisciplinary Training in Ethnic Diversity and Cancer Disparities

健康差距的根源是生物、社会、文化、行为和经济方面的多样性 个体和群体的特征。对种族/种族差异的研究始于一个 了解每一组的特征以及这些特征如何影响癌症的发展 和结果。这是夏威夷大学T32博士后联合培训项目的新申请 癌症中心和南加州大学诺里斯综合癌症中心 (NCCC)利用一种独特的资源--多种族队列研究(MEC)--解决癌症健康差距问题 一项基于人口的前瞻性队列研究，跟踪了非裔美国人、夏威夷原住民和日本人 美国人、拉丁裔和白人在过去的25年里。与癌症登记处、医疗保险和其他数据的联系 来源为MEC和许多其他癌症差异研究提供了各种终点 机构。UCC和USC的互补研究得到了尖端核心和优势的支持 从多年的经验来看。拟议培训方案的具体目标是： 1.培训博士后研究员，以便在不同人群中独立从事癌症研究，并具有 特别关注导致癌症健康的社会文化、营养、生活方式和生物风险因素 不同族裔/种族少数群体之间的差异。该计划具有很高的独特性，将利用长期的 NCI指定的两个癌症中心的研究项目之间的长期(30多年)合作 允许在流行病学研究的培训和工具方面有更广泛的经验。 2.在注重营养的多学科环境中提供广泛的应用研究经验， 建立在多种独特的种族和民族基础上的分子、遗传和翻译流行病学 对癌症的多样化研究。再加上强有力的指导，这些研究将成为 有效的跨学科培训，这将使受训者能够设计创新的高影响力项目， 并将为从事癌症健康差异研究的受训人员做好准备。 在为期5年的资助期间，培训计划将在夏威夷培养8名博士后研究员，在洛杉矶培养10名博士后研究员。 安吉。所有受训人员将接触到一系列创新的分子和传统癌症预防 解决广泛癌症差异的方法(流行病学、生物标记物、基因组学和营养学) 通过密切合作，在夏威夷和加利福尼亚州的种族/种族人群中研究问题 两个地点的导师和定期的互访。双点培训，定期包括 互访，是拟议的培训方案的一个特别优势，因为它将提供接触到多个 机构和多学科协作研究，建立在专业知识和长期 南加州大学和南加州大学在研究、教育和培训方面的合作。

At the root of health disparities is the diversity in the biological, social, cultural, behavioral, and economic characteristics of individuals and populations. The study of ethnic/racial disparities begins with an understanding of the characteristics of each group and how these characteristics affect cancer development and outcomes. This new application for a joint T32 postdoctoral training program at University of Hawaii Cancer Center (UHCC) and the University of Southern California (USC) Norris Comprehensive Cancer Center (NCCC) addresses cancer health disparities utilizing a unique resource, the Multiethnic Cohort (MEC) Study, a population-based prospective cohort study that has followed African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites for the past 25 years. Linkages to cancer registries, Medicare, and other data sources provide a variety of endpoints for MEC and many other cancer disparity studies conducted at both institutions. The complementary research at UHCC and USC is supported by cutting edge cores and benefits from many years of experience. The specific aims of the proposed training program are: 1. To train postdoctoral fellows for independent careers in cancer research in diverse populations, with a specific focus on the sociocultural, nutritional, lifestyle and biological risk factors leading to cancer health disparities in a variety of ethnic/racial minorities. This program is highly unique and will leverage the long- standing (30+ years) collaboration between research programs at two NCI-designated Cancer Centers to permit a broader experience in training and tools for epidemiological research. 2. To provide extensive applied research experience in a multidisciplinary environment focusing on nutritional, molecular, genetic and translational epidemiology that builds on multiple unique racial and ethnically diverse studies of cancer. Together with strong mentorship, these studies will serve as the centerpiece for an effective transdisciplinary training, which will allow trainees to design innovative high-impact projects, and will prepare trainees for careers in cancer health disparities research. During the 5-year grant period, the training program will educate 8 postdoctoral fellows in Hawaii and 10 in Los Angeles. All trainees will be exposed to a wide range of innovative molecular and traditional cancer prevention approaches (epidemiology, biomarkers, genomics, and nutrition) to address a wide range of cancer disparity research questions across the ethnic/racial populations in Hawaii and California through the close cooperation of mentors in both locations and regular exchange visits. The dual-site training, which regular includes exchange visits, is a particular strength of the proposed training program as it will provide exposure to multi- institutional and multi-disciplinary collaborative research that builds on the expertise and long-standing collaboration between UH and USC in research, education and training.