Center for Human Health and the Environment (CHHE)

人类健康与环境中心(CHHE)的愿景是成为全球领先的 环境健康科学(EHS)通过建立在北卡罗来纳州州立大学的基础上，从基因到种群的连续体 在数量生物学、组学和分析技术方面的独特研究优势和资源，以及 多样化的模式生物，以及它在人类种群科学中的新兴力量。通过 有目的地对接不同学科和整合所有层次的系统生物学框架 生物组织--生物分子、途径、细胞、组织、器官、模型生物、人和人 人口-CHHE将阐明环境应激源相互作用的基本机制 通过影响人类健康结果的途径、基因组和表观基因组。车已经做出了 第一个供资周期取得了显著进展。车有显著的：(1)先进创新多 学科EHS团队研究；(2)扩大其NIEHS赠款基础；(3)提高其合作伙伴的EHS能力 机构，东卡罗来纳大学和北卡罗来纳中央大学；(4)培养下一代 EHS领导人；以及(5)与受有毒物质影响的社区建立多方向的接触 金属和全氟烷基和多氟烷基物质。在我们的第一个资助周期中，四个研究兴趣小组 (钻机)有机进化和新出现的污染物，环境表观遗传学和遗传学， 肺健康、行为和神经科学钻机现在代表CHHE主题领域。在即将到来的时候 周期，我们已经增强了我们的三个设施核心，以增加影响以及基础科学和翻译 我们会员的身份。系统技术核心提供尖端技术，包括 基因组学、代谢组学、金属组学和蛋白质组学。《比较病理学》核心提供了病理学 对成员使用的许多模式生物的表型评估和带有链接的成像支持 到组学技术。综合健康科学设施核心促进了两国之间的双向翻译 通过为以下方面提供数据科学分析和可视化支持，实现基础科学和公共卫生成果 分析人口和多组学研究以及以人口为基础的研究专门知识。作为一块土地- 北卡罗来纳州格兰特大学有一个致力于社区参与的哲学，这是对Chhe 社区参与核心并促进CHHE与北卡罗来纳州受影响社区之间的关系 导致研究人员、教育工作者和公民之间的协作互动，以增强EHS知识， 识字和健康。针对职业生涯早期和中期调查人员的强有力的职业发展计划是 与支持协作和多学科EHS项目的强有力的试点项目计划相协调 以提高我们成员的研究成果。我们的使命是继续发展成为一名总理 NIEHS EHS核心中心，作为北卡罗来纳州EHS研究的纽带，提供重点、资源、 以及对跨学科研究的领导，这将改善当地、国家和全球的人类健康。

The vision of the Center for Human Health and the Environment (CHHE) is to become a global leader in environmental health sciences (EHS) along the continuum from genes to populations by building on NC State’s unique research strengths and resources in quantitative biology, -omics and analytical technologies, and diverse model organisms, as well as its emerging strength in human population science. Through the purposeful interfacing of different disciplines and a systems biology framework integrating all levels of biological organization - biomolecule, pathway, cell, tissue, organ, model organism, human, and human population - CHHE will elucidate fundamental mechanisms through which environmental stressors interface with pathways, the genome, and epigenome to influence human health outcomes. CHHE has made outstanding progress in the first funding cycle. CHHE has significantly: (1) advanced innovative multi- disciplinary EHS team research; (2) expanded its NIEHS grant base; (3) increased EHS capacity at its partner institutions, East Carolina University and North Carolina Central University; (4) cultivated the next generation of EHS leaders; and (5) developed multi-directional engagement with communities affected by exposure to toxic metals and per- and polyfluoroalkyl substances. During our first funding cycle, four Research Interest Groups (RIGs) evolved organically and the Emerging Contaminants, Environmental Epigenetics and Genetics, Pulmonary Health, and Behavior and Neuroscience RIGs now represent CHHE thematic areas. In the coming cycle, we have enhanced our three facility cores to increase the impact and the basic science and translational capacity of our membership. The Systems Technologies Core provides cutting-edge technologies involving genomics, metabolomics, metallomics, and proteomics. The Comparative Pathology Core provides pathologic phenotypic assessment of the many model organisms used by members and imaging support with links back to omics technologies. The Integrative Health Science Facility Core facilitates bidirectional translation between basic science and public health outcomes by providing data science analysis and visualization support for analysis of human population and multi-omic studies as well as population-based study expertise. As a land- grant university, NC State has a dedicated community engagement philosophy that augments CHHE’s Community Engagement Core and fosters relationships between CHHE and affected communities in NC which leads to collaborative interaction among researchers, educators, and citizens to enhance EHS knowledge, literacy, and health. A strong Career Development Program for early- and mid-career investigators is coordinated with a robust Pilot Project Program that supports collaborative and multidisciplinary EHS projects to enhance the research success of our members. Our CHHE mission is to continue to evolve as a premier NIEHS EHS Core Center and serve as the nexus of EHS research at NC State by providing focus, resources, and leadership for interdisciplinary research that will improve human health locally, nationally, and globally.