Center for Human Health and the Environment (CHHE)

人类健康与环境中心（CHHE）的愿景是成为全球领导者， 环境健康科学（EHS）沿着从基因到人口的连续统一体，建立在北卡罗来纳州的 在定量生物学、组学和分析技术方面的独特研究优势和资源，以及 多样的模式生物，以及它在人类人口科学中的新兴力量。通过 不同学科的有目的的接口和系统生物学框架， 生物组织-生物分子、途径、细胞、组织、器官、模式生物、人类和人类 人口- CHHE将阐明通过环境压力接口的基本机制 基因组和表观基因组来影响人类健康结果。CHHE已经 在第一个供资周期取得突出进展。CHHE具有显著的：（1）先进的创新多功能， 学科EHS团队研究;（2）扩大了NIEHS资助基础;（3）提高了合作伙伴的EHS能力 机构，东卡罗莱纳大学和北卡罗来纳州中央大学;（4）培养下一代 EHS领导人;以及（5）与受有毒物质影响的社区开展多方向的合作 金属以及全氟烷基和多氟烷基物质。在我们的第一个资助周期，四个研究兴趣小组， （RIGs）有机进化和新兴污染物，环境表观遗传学和遗传学， 肺健康，行为和神经科学RIG现在代表CHHE主题领域。在未来几 循环，我们已经加强了我们的三个设施核心，以增加影响和基础科学和转化 我们的会员资格。系统技术核心提供尖端技术， 基因组学、代谢组学、金属组学和蛋白质组学。比较病理学核心提供病理学 成员使用的许多模式生物的表型评估和图像支持， 到组学技术。综合健康科学设施核心促进双向翻译之间 通过提供数据科学分析和可视化支持， 人口分析和多组学研究以及基于人口的研究专业知识。作为一片土地- 补助大学，北卡罗来纳州有一个专门的社区参与理念，增强CHHE的 社区参与核心和促进CHHE和NC受影响社区之间的关系， 导致研究人员，教育工作者和公民之间的协作互动，以提高EHS知识， 识字和健康。为职业生涯早期和中期的调查员提供强大的职业发展计划， 与支持协作和多学科EHS项目的强大试点项目计划协调 提高我们成员的研究成功率。我们的CHHE使命是继续发展成为首屈一指的 NIEHS EHS核心中心，通过提供重点，资源， 和跨学科研究的领导力，将改善当地，国家和全球的人类健康。

The vision of the Center for Human Health and the Environment (CHHE) is to become a global leader in environmental health sciences (EHS) along the continuum from genes to populations by building on NC State’s unique research strengths and resources in quantitative biology, -omics and analytical technologies, and diverse model organisms, as well as its emerging strength in human population science. Through the purposeful interfacing of different disciplines and a systems biology framework integrating all levels of biological organization - biomolecule, pathway, cell, tissue, organ, model organism, human, and human population - CHHE will elucidate fundamental mechanisms through which environmental stressors interface with pathways, the genome, and epigenome to influence human health outcomes. CHHE has made outstanding progress in the first funding cycle. CHHE has significantly: (1) advanced innovative multi- disciplinary EHS team research; (2) expanded its NIEHS grant base; (3) increased EHS capacity at its partner institutions, East Carolina University and North Carolina Central University; (4) cultivated the next generation of EHS leaders; and (5) developed multi-directional engagement with communities affected by exposure to toxic metals and per- and polyfluoroalkyl substances. During our first funding cycle, four Research Interest Groups (RIGs) evolved organically and the Emerging Contaminants, Environmental Epigenetics and Genetics, Pulmonary Health, and Behavior and Neuroscience RIGs now represent CHHE thematic areas. In the coming cycle, we have enhanced our three facility cores to increase the impact and the basic science and translational capacity of our membership. The Systems Technologies Core provides cutting-edge technologies involving genomics, metabolomics, metallomics, and proteomics. The Comparative Pathology Core provides pathologic phenotypic assessment of the many model organisms used by members and imaging support with links back to omics technologies. The Integrative Health Science Facility Core facilitates bidirectional translation between basic science and public health outcomes by providing data science analysis and visualization support for analysis of human population and multi-omic studies as well as population-based study expertise. As a land- grant university, NC State has a dedicated community engagement philosophy that augments CHHE’s Community Engagement Core and fosters relationships between CHHE and affected communities in NC which leads to collaborative interaction among researchers, educators, and citizens to enhance EHS knowledge, literacy, and health. A strong Career Development Program for early- and mid-career investigators is coordinated with a robust Pilot Project Program that supports collaborative and multidisciplinary EHS projects to enhance the research success of our members. Our CHHE mission is to continue to evolve as a premier NIEHS EHS Core Center and serve as the nexus of EHS research at NC State by providing focus, resources, and leadership for interdisciplinary research that will improve human health locally, nationally, and globally.